42例肉芽肿性小叶炎患者的激素水平特征分析

Characteristics of Hormone Levels in 42 Patients with Granulomatous Lobular Mastitis

摘要: 目的：总结并分析肉芽肿性小叶炎患者的激素水平特征，寻求疾病的实验室特征及为激素治疗提供依据。方法：回顾性分析2020年1月至2021年3月在昆明市第一人民医院经过手术病检证实为肉芽肿性小叶炎患者的临床资料，观察其流行病学特征，统计实验室检查结果，评估激素水平是否超过正常参考值范围。结果：共纳入42例病理学诊断为肉芽肿性小叶炎的患者，42例患者均处在正常月经周期内。手术前抽血检查，其中32例患者处于卵泡期，10例患者处于黄体期。卵泡期雌激素通过实验样本的均数值与总体正常人群的均数值的t检验结果，不拒绝H0，两者的差别无统计学意义，但黄体期雌激素水平通过t检验，两者差别具有统计学意义。泌乳素根据通过实验样本的均数值与总体正常人群的均数值的t检验结果，两者的差别具有统计学意义，呈阳性结果。结论：肉芽肿性小叶炎患者的雌激素水平在卵泡期较正常人群无明显差异，而在黄体期较正常人群存在统计学差异(较正常偏低)，泌乳素水平则与正常人群具有显著的统计学差异，表明雌激素水平的变化及泌乳素水平的增高可能影响到疾病的发生。

Abstract: Purpose: Summarize and analyze the characteristics of hormone levels in patients with granulomatous lobular mastitis to discover the laboratory characteristics of the disease and provide the basis for hormone therapy. Method: Retrospective analysis was performed on the clinical data of patients with granulomatous lobular mastitis confirmed by after surgery pathological test in the First People’s Hospital of Kunming from January 2020 to March 2021. The epidemiological characteristics were observed while the results of laboratory tests were counted to assess whether the hormone levels exceeded the normal reference range. Result: A total of 42 patients with pathologically diagnosed granulomatous lobular mastitis were included. When all patients take the before-surgery blood test, of 42 patients who were in normal menstrual cycles, 32 patients were in the follicular stage and 10 patients were in the beta phase. T-test was conducted between the mean values of the experimental samples and the normal population. The result of estrogen level in the follicular stage did not reject H0, and the difference between the two was not statistically. But the result of estrogen level in the beta phase did reject H0, the difference between the two was statistically significant. The difference in prolactin level between the two groups was statistically significant and the prolactin results are positive. Conclusion: For the estrogen levels with granulomatous lobular mastitis. There was no significant difference in the follicular stage, but in the beta phase, there were statistically significant differences (lower than the normal population), and the prolactin level was significantly different from the normal population. These may indicate that the estrogen level and the prolactin level may affect the disease.