儿童黑斑息肉综合征合并肠套叠临床手术治疗的原则分析
Analysis of the Principles of Clinical Surgical Treatment of Children with Peutz-Jeghers Syndrome with Intussusception
摘要: 目的：探讨儿童黑斑息肉综合征合并肠套叠的临床手术治疗原则。方法：回顾性分析近2个月来青岛大学附属医院小儿外科市南院区收治的2例黑斑息肉综合征合并肠套叠患儿的临床资料。结果：2例均行急症剖腹探查手术治疗，均出现术后复套并再次行手术治疗，再次手术中均出现迟发性肠坏死。结论：儿童黑斑息肉综合征对术中可扪及的息肉及已经缺血即使恢复的肠段应及时给予切除。
Abstract: Objective: The objective is to explore the principles of clinical surgical treatment of children with Peutz-Jeghers syndrome with intussusception. Methods: It is a retrospective analysis of the clinical data of 2 children with Peutz-Jeghers syndrome and intussusception in the Pediatric Surgery District of Qingdao University Affiliated Hospital in the past 2 months. Results: Both cases underwent emergency laparotomy and exploratory surgery, and both had post-surgical cover and re-operation. Delayed intestinal necrosis occurred during the re-operation. Conclusion: Pediatric Peutz-Jeghers syndrome should be promptly removed for the polyps that can be palpated during the operation and the intestinal segment that has been ischemia even if it has recovered.
文章引用：孙鑫鑫, 郝希伟. 儿童黑斑息肉综合征合并肠套叠临床手术治疗的原则分析[J]. 临床医学进展, 2021, 11(9): 4212-4215. https://doi.org/10.12677/ACM.2021.119615

参考文献

[1] 贾燕, 傅豪, 李娜, 康倩, 盛剑秋. 46例黑斑息肉综合征的诊治[J]. 中南大学学报(医学版), 2018, 43(12): 1323-1327.
[2] 刘金霞, 周平. Peutz-Jeghers综合征致病基因的研究[J]. 空军总医院学报, 2010, 26(4): 209-213.
[3] 赵可, 董新华, 陈长宽, 向瑗瑗, 张谢夫. 黑斑息肉综合征13例分析[J]. 河南外科学杂志, 2017, 23(5): 25-26.
[4] 陈方慧, 王弋. Peutz-Jeghers综合征诊治进展[J]. 中华危重症医学杂志(电子版), 2014, 7(6): 428-430.
[5] Richards, S., Aziz, N., Bale, S., et al. (2015) Standards and Guidelines for the Interpretation of Sequence Variants: A Joint Consensus Recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genetics in Medicine, 17, 405-424. [Google Scholar] [CrossRef] [PubMed]
[6] Wang, Z.Q., Wu, B.P., Mosig, R.A., Chen, Y.L., Ye, F., Zhang, Y.L., Gong, W., Gong, L.B., Huang, F., Wang, X.Y., Nie, B., Zheng, H.X., Cui, M., Wang, Y.D., Wang, J., Chen, C., Polydorides, A.D., Zhang, D.Y., Martignetti, J.A. and Jiang, B. (2014) STK11 Domain XI Mutations: Candidate Genetic Drivers Leading to the Development of Dysplastic Polyps in Peutz-Jeghers Syndrome. Human Mutation, 35, 851-858. [Google Scholar] [CrossRef] [PubMed]
[7] Beggs, A.D., Latchford, A.R., Vasen, H.F.A., et al. (2010) Peutz-Jeghers Syndrome: A Systematic Review and Recommendations for Management. Gut, 59, 975-986. [Google Scholar] [CrossRef] [PubMed]
[8] 康连春, 赵敏, 张家芳, 张世华, 朱铁雁, 范登华, 郭凌, 康素海, 吕有勇. 黑斑-息肉综合征染色体不稳定性及肿瘤易感基因位点的分析[J]. 中华医学杂志, 1999(10): 735-738.
[9] 陈方慧, 王弋. Peutz-Jeghers综合征诊治进展[J]. 中华危重症医学杂志(电子版), 2014, 7(6): 428-430.
[10] 胡顺彩. Peutz-Jeghers综合征8例临床分析[J]. 中国医师杂志, 2006, 8(1): 92.
[11] Hearle, N., Schumacher, V., Menko, F.H., et al. (2006) STK11 Status and Intussusception Risk in Peutz-Jeghers Syndrome. Journal of Medical Genetics, 43, e41. [Google Scholar] [CrossRef] [PubMed]
[12] 王炼, 张丹, 由广强, 张航, 乔士兴. 黑斑息肉综合征合并肠套叠1例[J]. 中国实验诊断学, 2019, 23(1): 89-90.

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