重复经颅磁刺激治疗帕金森病失眠疗效的Meta分析
Transcranial Magnetic Stimulation for Insomnia in Parkinson’s Disease: Meta Analysis
摘要: 目的：综合评估重复经颅磁刺激(rTMS)治疗帕金森病失眠的疗效。方法：计算机检索中国知网(CNKI)、万方等数据库中重复经颅磁刺激治疗帕金森病失眠的随机对照实验(RCT)，检索时限为建库到2021年3月，进行文献质量评估，采用RevMan5.4软件进行Meta分析。结果：共纳入8项RCT研究，包含480例患者。Meta分析结果显示，两组在PDSS-2评分(SMD = −7.60, 95%CI: −11.12~−4.08, P = 0.79)、UPDRS (SMD = −6.20, 95%CI: −7.69~−4.71, P = 0.60)和PSQI (效应量MD = −1.73, 95%CI: −2.04~−1.42, P ≤ 0.00001)方面差异有统计学意义。结论：rTMS能缓解帕金森病患者的失眠程度，提高患者睡眠质量。
Abstract: Objective: The objective is to comprehensively evaluate the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) on insomnia caused by Parkinson’s disease. Methods: Randomized controlled trials (RCTs) of repeated transcranial magnetic stimulation in the treatment of insomnia in Parkinson’s disease were searched from CNKI and Wanfang databases by computer. The retrieval time was from the establishment of the database to March 2021. The literature quality was evaluated, and Meta-analysis was performed using RevMan5.4 software. Results: Eight RCT studies were included, including 480 patients. Meta analysis showed that the scores of PDSS-2 (SMD = −7.60, 95%CI: −11.12~−4.08, P = 0.79), UPDRS (SMD = −6.20, 95%CI: −7.69~−4.71, P = 0.60) and PSQI (effect size MD=−1.73, 95%CI: −2.04~−1.42, P ≤ 0.00001) was statistically significant. Conclusion: rTMS can relieve insomnia and improve sleep quality of patients with Parkinson’s disease.
文章引用：朱嘉卉, 贾梦真, 王吉付, 宋倩. 重复经颅磁刺激治疗帕金森病失眠疗效的Meta分析[J]. 临床医学进展, 2021, 11(9): 4290-4297. https://doi.org/10.12677/ACM.2021.119628

参考文献

[1] Louter, M., Aarden, W.C.C.A., Lion, J., Bloem, B.R. and Overeem, S. (2012) Recognition and Diagnosis of Sleep Disorders in Parkinson’s Disease. Journal of Neurology, 259, 2031-2040. [Google Scholar] [CrossRef] [PubMed]
[2] Ylikoski, A., Martikainen, K., Sieminski, M. and Partinen, M. (2015) Parkinson’s Disease and Insomnia. Neurological Sciences, 36, 2003-2010. [Google Scholar] [CrossRef] [PubMed]
[3] 朱其凤. 帕金森病睡眠障碍的研究概况[J]. 广西中医药大学学报, 2016, 19(2): 101-104.
[4] 张佩兰, 程炎, 王旭光. 国产托卡朋片治疗帕金森病有效性及安全性的临床研究[J]. 河北医药, 2006, 28(4): 245-248. [Google Scholar] [CrossRef] 
[5] Hu, X.-Y., Zhang, T., Rajah, G.B., Stone, C., Liu, L.-X., He, J.-J., Shan, L., Yang, L.-Y., Liu, P., Gao, F., Yang, Y.-Q., Wu, X.-L., Ye, C.-Q. and Chen, Y.-D. (2018) Effects of Different Frequencies of Repetitive Transcranial Magnetic Stimulation in Stroke Patients with Non-Fluent Aphasia: A Randomized, Sham-Controlled Study. Neurological Research, 40, 459-465. [Google Scholar] [CrossRef] [PubMed]
[6] 陈静, 朱红灿. 重复经颅磁刺激治疗帕金森病失眠患者临床分析[J]. 中国实用神经疾病杂志, 2020, 23(3): 216-219.
[7] 吴卓华, 崔立谦, 邵明, 谭红愉, 吴宜娟, 许启锋, 等. 重复经颅磁刺激治疗帕金森病失眠临床观察[J]. 江苏大学学报(医学版), 2013, 23(4): 354-356.
[8] 吴少璞, 李学, 祁亚伟, 王恒, 庄卫生, 杨红旗, 等. 重复经颅磁刺激联合康复训练改善帕金森病运动及非运动症状的疗效观察[J]. 中华物理医学与康复杂志, 2019, 41(5): 338-343. [Google Scholar] [CrossRef] 
[9] 张峰菊, 王晓雪, 刘欣欣. 重复经颅磁刺激联合认知行为疗法对帕金森病非运动症状的疗效[J]. 中国实用神经疾病杂志, 2017, 20(9): 61-63. [Google Scholar] [CrossRef] 
[10] 张文静, 聂坤, 张玉虎, 黄惠根, 李少芳, 古瑞平. 重复经颅磁刺激治疗帕金森病失眠患者的效果观察[J]. 护理学报, 2014, 21(23): 28-30.
[11] 张永强. 高频经颅磁刺激治疗帕金森病非运动症状的临床研究[J]. 中国基层医药, 2017, 24(22): 3441-3444. [Google Scholar] [CrossRef] 
[12] 李越, 王玉平, 詹淑琴, 黄朝阳, 姜凤英, 侯月, 等. 重复经颅磁刺激治疗广泛性焦虑的对照研究[J]. 脑与神经疾病杂志, 2012, 20(2): 84-88. [Google Scholar] [CrossRef] 
[13] 王铭维, 顾平, 马晓伟, 李艳敏, 王彦永, 郭记宏, 等. 低频重复经颅磁刺激对帕金森病运动功能和情感障碍的疗效观察[J]. 中华老年医学杂志, 2009, 28(9): 729-732. [Google Scholar] [CrossRef] 
[14] 许宏侠, 王晓雪, 刘欣欣. 重复经颅磁刺激对帕金森病运动与非运动症状的影响[J]. 中国现代医生, 2015(14): 87-89.
[15] Paeehetti, C., Manni, R., Zangaglia, R., Glorioso, M., Cristina, S., Terzaghi, M., et al. (2004) A Questionnaire on Sleep and Mental Disorders in Parkinson’s Disease (QSMDPD): Development and Application of a New Screening Tool. Functional Neurology, 19, 83-99.
[16] Yamazaki, Y., Sato, D., Yamashiro, K., Nakano, S., Onishi, H. and Maruyama, A. (2019) Acute Low-Intensity Aerobic Exercise Modulates Intracortical Inhibitory and Excitatory Circuitsinan Exercisedanda Non-Exercised Musclein the Primary Motor Cortex. Frontiers in Physiology, 10, Article No. 1361. [Google Scholar] [CrossRef] [PubMed]
[17] Kovács, N., Horváth, K., Aschermann, Z., Ács, P., Bosnyák, E., Deli, G., Pál, E., Janszky, J., Faludi, B., Karádi, K., Késmárki, I., Bokor, M., Rigó, E., Lajtos, J., Klivényi, P., Dibó, G., Vécsei, L., Takáts, A., Tóth, A., Imre, P., Nagy, F., Herceg, M., Kamondi, A., Hidasi, E. and Komoly, S. (2016) Independent Validation of Parkinson’s Disease Sleep Scale 2nd Version (PDSS-2). Sleep and Biological Rhythms, 14, 63-73. [Google Scholar] [CrossRef] 
[18] Rodriguez-Blazquez, C., Wetmore, J., Serrano-Duenas, M., Pedroso, I., Carlos Martinez-Castrillo, J., Bernal, O., et al. (2018) International Validation of the Spanish Version of the Parkinson’s Disease Sleep Scale 2 (PDSS-2). Quality of Life Research, 27, S70-S71.
[19] 黄馨懿, 朱继民, 湛宇灿, 李白坤. 基于PSQI的中国大学生睡眠质量研究及影响因素的中医认知[J]. 世界睡眠医学杂志, 2019, 6(7): 891-894. [Google Scholar] [CrossRef] 
[20] 路桃影, 李艳, 夏萍, 张广清， 吴大嵘. 匹兹堡睡眠质量指数的信度及效度分析[J]. 重庆医学, 2014(3): 260-263. [Google Scholar] [CrossRef] 
[21] Tsanas, A., Little, M.A., McSharry, P.E. and Ramig, L.O. (2011) Nonlinear Speech Analysis Algorithms Mapped to a Standard Metric Achieve Clinically Useful Quantification of Average Parkinson’s Disease Symptom Severity. Journal of the Royal Society Interface, 8, 842-855. [Google Scholar] [CrossRef] [PubMed]
[22] 林钢, 季薇. 基于迭代决策树的帕金森UPDRS预测模型研究[J]. 计算机技术与发展, 2019, 29(1): 216-220. [Google Scholar] [CrossRef] 

为你推荐