微小RNA在妊娠期糖尿病中的研究进展
The Research Progress of miRNA in Gestational Diabetes
DOI: 10.12677/ACM.2021.119635, PDF,   
作者: 张彬彬, 杨琪媛：大连医科大学，辽宁 大连；瓮占平*：青岛市市立医院，山东 青岛
关键词: 微小RNA；妊娠期糖尿病；分子生物标志物；MicroRNA； Gestational Diabetes Mellitus； Molecular Biomarkers
摘要: 微小RNA是一类高度保守的内源性单链RNA序列，在各种细胞类型中均可表达。妊娠期糖尿病是妊娠期间首次诊断的糖耐量异常。该病由多因素导致，且其发病机制尚不明确，可引起多种并发症，对母婴均可造成巨大危害。妊娠期糖尿病患者血液中的某些miRNA与正常孕妇相比存在差异表达，有作为早期诊断的分子生物标志物的潜力，不同miRNA可通过不同的方式参与妊娠期糖尿病的发生、发展。此综述主要讨论miRNA在GDM中的作用机制、早期诊断及治疗方面的研究进展。
Abstract: MicroRNA is a highly conserved endogenous single-stranded RNA sequence, which can be expressed in various cell types. Gestational diabetes mellitusis the first diagnosis of impaired glucose tolerance during pregnancy. It is caused by multiple factors, and its pathogenesis is not clear. It can cause a variety of complications and cause great harm to mothers and babies. Some miRNAs in the blood of patients with gestational diabetes are differentially expressed compared with normal pregnant women, and they have the potential as molecular biomarkers for early diagnosis. Different miRNAs can participate in the occurrence and development of gestational diabetes in different ways. This review mainly discusses the research progress of miRNA in GDMonthemechanism, early diagnosis and treatment.
文章引用：张彬彬, 杨琪媛, 瓮占平. 微小RNA在妊娠期糖尿病中的研究进展[J]. 临床医学进展, 2021, 11(9): 4338-4344. https://doi.org/10.12677/ACM.2021.119635

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