拟南芥IDZ基因的系统发育、分子进化分析
Phylogenetic and Molecular Evolution Analysis of IDZ Gene in Arabidopsis thaliana
摘要: Cys2His2 (C2H2)型锌指蛋白是广泛存在于真核生物转录因子中的DNA结合模体。在大多数情况下，含有C2H2型锌指结构的蛋白是基因表达调控中的重要的转录调节因子，在细胞发育、分化和抑制恶性细胞转化(抑瘤)等过程中起着重要作用。拟南芥是第一个完成全基因组测序的植物，并作为模式生物被广泛运用于植物生物学各领域的研究中。拟南芥IDZ基因家族以C2H2型锌指蛋白结构为特征。本文运用生物信息学对拟南芥IDZ基因家族中的11个蛋白编码基因进行理化性质、系统发育分析、蛋白保守基序、染色体定位、互作蛋白网络、蛋白质三维结构分析。结果提示同组成员包含相似的保守基序和序列结构，IDZ基因在染色体上分布均匀，不存在串联重复片段。本研究为进一步研究IDZ家族的生物学功能和价值提供了科学依据。
Abstract: The Cys2His2 (C2H2) type zinc finger protein is a DNA binding motif that exists widely in eukaryotic transcription factors. In most cases, proteins containing C2H2 type zinc finger structures are important transcription regulators in regulation of gene expression and play an important role in cell development, differentiation and inhibition of malignant cell transformation (tumor suppression). Arabidopsis was the first plant to complete the whole genome sequencing and is widely used as a model organism in various areas of plant biology. The IDZ gene family in Arabidopsis is characterized by the structure of C2H2 type zinc finger protein. In this study, 11 protein coding genes in IDZ gene family of Arabidopsis thaliana were analyzed by using bioinformatics, including physical and chemical properties, phylogenetic analysis, protein conserved motif, chromosome location, interacting protein network, and three-dimensional structure analysis. The results showed that the IDZ gene was distributed evenly on the chromosome and there were no tandem repeats in the IDZ gene. This study provides a scientific basis for further study on the biological function and value of the IDZ family.
文章引用：王嘉琪. 拟南芥IDZ基因的系统发育、分子进化分析[J]. 植物学研究, 2021, 10(5): 724-733. https://doi.org/10.12677/BR.2021.105091

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