基于水凝胶的生物材料再生修复退变椎间盘的研究进展
Recent Advances of Hydrogel‐Based Biomaterials Used for Regenerationof Nucleus Pulposus in Intervertebral Disc Degeneration
DOI: 10.12677/ACM.2021.1110639, PDF,   
作者: 张皓博, 胡斯乐, 赵宇楠：内蒙古医科大学，内蒙古 呼和浩特；内蒙古医科大学第二附属医院，内蒙古 呼和浩特
关键词: 水凝胶；椎间盘；椎间盘退变；再生医学；生物相容性材料；Hydrogel； Intervertebral Disc； Intervertebral Disc Degeneration； Regenerative Medicine； Biocompatible Material
摘要: 下腰痛是一种日益普遍的症状，主要与椎间盘退变有关。退变最早发生在髓核，髓核脱水和纤维环裂隙形成导致椎间盘突出及相关临床症状。水凝胶具有类似正常髓核组织的吸水和保水能力、良好的生物相容性和高度可调节的机械性能，被广泛地应用到椎间盘的再生修复治疗中。随着生物材料和组织工程技术的发展，水凝胶有望成为一种新的椎间盘退变性疾病的治疗策略。本文将对椎间盘退变的病理生理机制和水凝胶材料再生修复椎间盘的研究进展进行系统综述。
Abstract: Low back pain is an increasingly prevalent symptom mainly associated with intervertebral disc degeneration. Degeneration first occurs in the nucleus pulposus, and dehydration of the nucleus pulposus and annular fissure formation lead to disc herniation and associated clinical symptoms. Hydrogels are widely used in the regeneration and repair of intervertebral disc, because of water absorption and retention ability resembling the normal nucleus pulposus, good biocompatibility and tunable mechanical properties. With the development of biocompatible material and tissue engineering, hydrogel is expected to be a new treatment strategy for degenerative disc diseases. In this paper, the pathophysiological mechanism of intervertebral disc degeneration and the research progress of intervertebral disc regeneration with hydrogel materials are reviewed.
文章引用：张皓博, 胡斯乐, 赵宇楠. 基于水凝胶的生物材料再生修复退变椎间盘的研究进展[J]. 临床医学进展, 2021, 11(10): 4365-4372. https://doi.org/10.12677/ACM.2021.1110639

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