H型高血压患者的尿白蛋白肌酐比值变化及其临床意义

Changes of Urinary Albumin-Creatinine Ratio in Patients with H-Type Hypertension and Their Clinical Significance

摘要: 目的：探讨H型高血压患者的尿白蛋白肌酐比值改变及其临床意义。方法：104例原发性高血压患者根据血清中同型半胱氨酸是否小于10 μmol/L分为H型高血压组和单纯高血压组，48例健康成人作为健康对照组。检测三组尿白蛋白、尿肌酐、血尿素氮、血肌酐和血胱抑素C水平，分析上述指标的差异。结果：1) 三组的血尿素氮、血肌酐和血胱抑素C水平有显著差异(p < 0.05)，但三组血尿素氮、血肌酐和血胱抑素C超过参考区间的比例虽有差异，但差异无统计学意义(p > 0.05)；2) 三组间的尿白蛋白、尿肌酐和尿白蛋白肌酐比值有显著差异，差异有统计学意义(p < 0.05)；3) H型高血压患者Hcy水平与尿白蛋白肌酐比值呈现明显正相关(r = 0.713, p = 0.010)。结论：尿白蛋白肌酐比值可用于明确H型高血压患者的早期肾损伤。

Abstract: Objective: To investigate the changes of urine albumin-creatinine ratio in patients with H-type hypertension and its clinical significance. Methods: 104 patients with essential hypertension were divided into H-type hypertension group and simple hypertension group according to whether their serum homocysteine was less than 10 μmol/L, and 48 healthy adults served as the healthy control group. The three groups of urine albumin, urine creatinine, blood urea nitrogen, blood creatinine and blood cystatin C levels were detected, and the differences in the above indicators were analyzed. Results: 1) The levels of blood urea nitrogen, blood creatinine and blood cystatin C in the three groups were significantly different (p <0.05), but the proportions of blood urea nitrogen, blood creatinine and blood cystatin C exceeding the reference interval among the three groups were different, the difference was not statistically significant (p > 0.05); 2) The ratios of urine albumin, urine creatinine and urine albumin creatinine among the three groups are significantly different, and the difference is statistically significant (p < 0.05); 3) The Hcy level of patients with H-type hypertension was significantly positively correlated with the ratio of urinary albumin and creatinine (r = 0.713, p = 0.010). Conclusion: The ratio of urine albumin to creatinine can be used to identify early renal injury in patients with H-type hypertension.