SLC7A11的低表达与肝癌患者预后的相关性分析

Correlation Analysis of SLC7A11 Low Expression and Prognosis of Patients with Liver Cancer

摘要: 目的：基于癌症基因组图谱(TCGA)分析SLC7A11基因的表达与肝癌患者预后的相关性。方法：从TCGA数据库下载369例肝癌患者和160未患肝癌患者的SLC7A11基因表达谱和病人临床相关信息，用R软件评估SLC7A11基因的表达与肝癌的发生以及各种临床病理学特征之间的关系；纳入山东大学齐鲁医院肝癌患者和正常的肝组织各6例，分析SLC7A11基因的相对表达量。结果：SLC7A11的表达与肝癌的发生有密切联系，高表达组的无病生存期和总生存期比低表达组更差。肝癌中SLC711的生物信息学分析表明，SLC711的表达与肝癌患者的肿瘤分期、T期和M期等临床病理特征相关。与正常肝组织相比，肝癌患者的肝组织中的SLC7A11的mRNA表达水平明显增高。结论：SLC711基因在肝癌中的临床相关性，可用于评估肝癌病人的预后。

Abstract: Objective: To analyze the correlation between the expression of SLC7A11 gene and the prognosis of liver cancer patients based on The Cancer Genome Atlas (TCGA). Methods: The SLC7A11 gene expression profiles of 369 patients with liver cancer and 160 patients without liver cancer and patient's clinically relevant information were downloaded from the TCGA database, and the relationship between the expression of the SLC7A11 gene and the occurrence of liver cancer and various clinicopathological features was assessed using R software; 6 cases each of liver cancer patients and normal liver tissues from the XX Centre were included to analyse the relative SLC7A11 gene expression. Results: Expression of SLC7A11 was strongly associated with hepatocarcinogenesis, and disease-free survival and overall survival were worse in the high expression group than in the low expression group. Bioinformatics analysis of SLC711 in hepatocellular carcinoma showed that the expression of SLC711 correlated with clinicopathological features such as tumour stage, T stage and M stage in patients with hepatocellular carcinoma. The mRNA expression level of SLC7A11 was significantly higher in liver tissues of hepatocellular carcinoma patients compared with normal liver tissues. Conclusion: The clinical relevance of SLC711 gene in hepatocellular carcinoma can be used to assess the prognosis of patients with hepatocellular carcinoma.