肺动脉内膜肉瘤1例并文献复习
Pulmonary Artery Intimal Sarcoma: A Case Report and Literature Review
DOI: 10.12677/ACM.2021.1111747, PDF,   
作者: 万甜甜, 栾琳慧, 丛金鹏, 陈云庆, 于文成*：青岛大学附属医院，山东 青岛
关键词: 肺动脉；内膜肉瘤；原发性；Pulmonary Artery； Intimal Sarcoma； Primary
摘要: 目的：分析肺动脉内膜肉瘤临床特点，为临床诊治提供参考。方法：对1例青岛大学附属医院呼吸与危重症医科的肺动脉内膜肉瘤患者的临床资料进行回顾性分析，并且复习相关文献。结果：建议回当地医院治疗；方案：靶向药物安罗替尼，从小剂量开始；或：安罗替尼 + PD-1抑制剂；或：化疗：异环磷酰胺 + 顺铂。结论：肺动脉内膜肉瘤较为罕见，发病率低，易误诊为肺栓塞，且预后极差，本文旨在提高临床认识，以期早诊断，提高生存率。
Abstract: Objective: To analyze the clinical features of pulmonary artery intimal sarcoma and provide reference for clinical diagnosis and treatment. Methods: The clinical data of 1 patient with pulmonary endosarcoma in the Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Qingdao University were analyzed retrospectively, and the related literatures were reviewed. The results suggest returning to the local hospital for treatment; protocol: targeted drug anlotinib, starting from a small dose; or: anlotinib + PD-1 inhibitor; or: chemotherapy: ifosfamide + cisplatin. Conclusion: Pulmonary artery intimal sarcoma is rare, with low incidence, easy to be misdiagnosed as pulmonary embolism, and very poor prognosis. The purpose of this paper is to improve the clinical understanding in order to diagnose early and improve the survival rate.
文章引用：万甜甜, 栾琳慧, 丛金鹏, 陈云庆, 于文成. 肺动脉内膜肉瘤1例并文献复习[J]. 临床医学进展, 2021, 11(11): 5073-5078. https://doi.org/10.12677/ACM.2021.1111747

参考文献

[1] Lebellec, L., Defachelles, A.-S., Cren, P.-Y. and Penel, N. (2020) Maintenance Therapy and Drug Holiday in Sarcoma Patients: Systematic Review. Acta Oncologica, 59, 1084-1090. [Google Scholar] [CrossRef] 
[2] Blackmon, S.H. and Reardon, M.J. (2010) Pulmonary Artery Sarcoma. Methodist DeBakey Cardiovascular Journal, 6, 38-43. [Google Scholar] [CrossRef] 
[3] Bandyopadhyay, D., et al. (2016) Primary Pulmonary Artery Sarcoma: A Close Associate of Pulmonary Embolism-20-Year Observational Analysis. Journal of Thoracic Disease, 8, 2592-2601. [Google Scholar] [CrossRef] [PubMed]
[4] Chen, D., et al. (2016) Clinicopathological and Immunohistochemical Features of Pulmonary Artery Sarcoma: A Report of Three Cases and Review of the Literature. Oncology Letters, 11, 2820-2826. [Google Scholar] [CrossRef] [PubMed]
[5] Deng, L., et al. (2018) Clinical Presentation and Surgical Treatment of Primary Pulmonary Artery Sarcoma. Interactive Cardiovascular and Thoracic Surgery, 26, 243-247. [Google Scholar] [CrossRef] [PubMed]
[6] Chang, D.Y., et al. (2020) Pulmonary Artery Intimal Sarcoma: A Case Report and Literature Review. Respirology Case Reports, 8, e00530. [Google Scholar] [CrossRef] [PubMed]
[7] Furest, I., et al. (2006) Intimal Sarcoma of the Pulmonary Artery: A Rare Cause of Pulmonary Hypertension. Archivos de Bronconeumología, 42, 148-150. [Google Scholar] [CrossRef] [PubMed]
[8] Attinà, D., et al. (2013) Pulmonary Artery Intimal Sarcoma. Problems in the Differential Diagnosis. La Radiologia Medica, 118, 1259-1268. [Google Scholar] [CrossRef] [PubMed]
[9] Pu, X., et al. (2018) Clinical and Radiological Features of Pulmonary Artery Sarcoma: A Report of Nine Cases. The Clinical Respiratory Journal, 12, 1820-1829. [Google Scholar] [CrossRef] [PubMed]
[10] Austin, B.A. and Griffin, B.P. (2008) Pulmonary Artery Intimal Sarcoma: A Brief Case Series. Journal of the American Society of Echocardiography: Official Publication of the American Society of Echocardiography, 21, 978.e5-978.e7. [Google Scholar] [CrossRef] [PubMed]
[11] Yi, C.A., et al. (2004) Computed Tomography in Pulmonary Artery Sarcoma: Distinguishing Features from Pulmonary Embolic Disease. Journal of Computer Assisted Tomography, 28, 34-39. [Google Scholar] [CrossRef] [PubMed]
[12] Barmpas, A., et al. (2019) Intimal Sarcoma of the Pulmonary Artery, a Diagnostic Enigma. AME Case Reports, 3, 32. [Google Scholar] [CrossRef] [PubMed]
[13] Han, Y., et al. (2021) Surgical Treatment of Primary Pulmonary Artery Sarcoma. General Thoracic and Cardiovascular Surgery, 69, 638-645. [Google Scholar] [CrossRef] [PubMed]
[14] Liu, M.X., et al. (2018) Differential Diagnosis of Pulmonary Artery Sarcoma and Central Chronic Pulmonary Thromboembolism Using CT and MR Images. Heart, Lung and Circulation, 27, 819-827. [Google Scholar] [CrossRef] [PubMed]
[15] Xi, X.Y., et al. (2019) Value of (18)F-FDG PET/CT in Differentiating Malignancy of Pulmonary Artery from Pulmonary Thromboembolism: A Cohort Study and Literature Review. The International Journal of Cardiovascular Imaging, 35, 1395-1403. [Google Scholar] [CrossRef] [PubMed]
[16] Al-Saffar, F., et al. (2015) Use of Endobronchial Ultrasound to Evaluate Nonthrombotic Endovascular Lesions in Pulmonary Arteries: A Systematic Review. Journal of Bronchology & Interventional Pulmonology, 22, 28-32. [Google Scholar] [CrossRef] 
[17] Balduin, R., Drigo, R., Schiraldi, C. and Carraro, R. (1986) Ante Mortem Diagnosis of Primary Leiomyosarcoma of the Pulmonary Artery. Respiration, 49, 307-310. [Google Scholar] [CrossRef] [PubMed]
[18] Blackmon, S.H., et al. (2009) Management of Primary Pulmonary Artery Sarcomas. The Annals of Thoracic Surgery, 87, 977-984. [Google Scholar] [CrossRef] [PubMed]
[19] Sejben, A., et al. (2020) Intimal Sarcoma of Pulmonary Arteries. Orvosi Hetilap, 161, 232-236. [Google Scholar] [CrossRef] [PubMed]
[20] Van der Graaf, W.T., et al. (2012) Pazopanib for Metastatic Soft-Tissue Sarcoma (PALETTE): A Randomised, Double-Blind, Placebo-Controlled Phase 3 Trial. The Lancet, 379, 1879-1886. [Google Scholar] [CrossRef] 
[21] Lee, Y., et al. (2016) Clinical Characteristics and Treatment Outcomes of Primary Pulmonary Artery Sarcoma in Korea. Journal of Korean Medical Science, 31, 1755-1760. [Google Scholar] [CrossRef] [PubMed]
[22] Srivali, N., Yi, E.S. and Ryu, J.H. (2017) Pulmonary Artery Sarcoma Mimicking Pulmonary Embolism: A Case Series. QJM, 110, 283-286. [Google Scholar] [CrossRef] [PubMed]

为你推荐