创伤性颅脑损伤预后血液生物标记物的研究进展
Research Progress of Blood Biomarkers for Prognosis of Traumatic Brain Injury
DOI: 10.12677/ACM.2021.1111756, PDF,   
作者: 李 显：青海大学研究生院，青海 西宁；贺瑛福：青海大学附属医院，青海 西宁
关键词: 颅脑损伤；标记物；预后；Traumatic Brain Injury； Marker； Prognosis
摘要: 创伤性颅脑损伤(traumatic brain injury, TBI)一直以来是造成青年人死亡、致残及地区经济负担的重要原因。由于机动车的普及，TBI的发病率在急剧提高。TBI多表现为局部的脑挫裂伤、脑血肿、脑白质束损伤及脑组织肿胀，其病情发展迅速且多变，严重威胁患者的生命安全。短暂的低灌注和低氧血症可能导致继发性损伤，导致更差的短期和长期预后。细胞损伤释放的特异性生物标记物可作为诊断TBI和评估损伤严重程度的一种手段。这些生物标志物可以通过实验室从血液样本中检测出来。目前已经研究了几十种TBI生物标志物，与其相关的研究正在增加。我们回顾最近的文献，并选择了12个快速简单准确评估TBI预后的生物标志物进行综述。
Abstract: Traumatic brain injury (TBI) has always been an important cause of death, disability and regional economic burden for young people. Due to the popularity of motor vehicles, the incidence of TBI is increasing sharply. TBI is mostly manifested as local brain contusion, cerebral hematoma, brain white matter tract injury and brain tissue swelling. Its condition develops rapidly and changeably, which seriously threatens the life safety of patients. Transient hypoperfusion and hypoxemia may lead to secondary injury, leading to worse short-term and long-term prognosis. Specific biomarkers released by cell damage can be used as a means to diagnose TBI and assess the severity of damage. At present, dozens of TBI biomarkers have been studied, and the related research is increasing. We reviewed the recent literature and selected 12 biomarkers for rapid, simple and accurate assessment of the prognosis of TBI for review.
文章引用：李显, 贺瑛福. 创伤性颅脑损伤预后血液生物标记物的研究进展[J]. 临床医学进展, 2021, 11(11): 5124-5131. https://doi.org/10.12677/ACM.2021.1111756

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