缺氧诱导因子在炎症性疾病中的研究进展
Research Progress of Hypoxia Inducible Factor in Inflammatory Diseases
DOI: 10.12677/ACM.2021.1111763, PDF,  被引量   
作者: 周 宇, 樊玉娟, 杨 林*：大理大学临床医学院，云南 大理；刘永磊：大理大学第一附属医院，云南 大理
关键词: 缺氧诱导因子；炎症性疾病；感染性疾病；新型冠状肺炎；Hypoxia Inducible Factor； Inflammatory Diseases； Infectious Disease； COVID-19
摘要: 缺氧诱导因子(Hypoxia-inducible factor, HIF)是一种转录因子，在细胞对低氧的反应中扮演重要角色，协调代谢开关，维持细胞生存。HIF的发现源于对促红细胞生成素(Erythropoietin, EPO)的研究，目前认为HIF在多种炎症性疾病中发挥着重要的生物学效应。本文对HIF在炎症性疾病，如肿瘤、自身免疫性疾病、组织损伤及各种感染性疾病中的最新进展以及新型冠状肺炎进行综述，以期为各种炎症性疾病的临床治疗提供参考。
Abstract: Hypoxia inducible factor (HIF) is a transcription factor that plays an important role in cell response to hypoxia, coordinating metabolic switches and maintaining cell survival. The discovery of HIF stems from the study of erythropoietin (EPO). At present, it is believed that HIF plays an important biological role in a variety of inflammatory diseases. This article reviews the latest research of HIF in inflammatory diseases, such as tumor, autoimmune disease, tissue injury and various infectious diseases, as well as the new type of coronal pneumonia, in order to provide reference for the clinical treatment of various inflammatory diseases.
文章引用：周宇, 刘永磊, 樊玉娟, 杨林. 缺氧诱导因子在炎症性疾病中的研究进展[J]. 临床医学进展, 2021, 11(11): 5170-5176. https://doi.org/10.12677/ACM.2021.1111763

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