高渗葡萄糖增生疗法治疗膝关节骨性关节炎疗效观察及分析

Observation and Analysis of Hypertonic Dextrose in the Treatment of Knee Osteoarthritis

摘要: 目的：观察超声引导下关节内注射高渗葡萄糖治疗膝关节骨性关节炎(KOA)的临床疗效，并对其机制进行探讨。方法：本研究选取符合纳入标准的56名KOA患者，在超声引导下向髌上囊注射20%葡萄糖8 ml，每隔2周注射1次，共注射3次。观察治疗前、治疗后2周、4周、8周VAS评分、WOMAC指数、40 m步行时间数值变化。结果：在治疗后2、4、8周KOA患者的VAS评分、WOMAC指数、40 m步行时间均较治疗前下降(P < 0.05)，差异有统计学意义。结论：超声引导下关节内注射高渗葡萄糖可以有效缓解KOA患者的疼痛，改善膝关节功能，可以成为临床治疗膝关节骨性关节炎疼痛的一种安全、有效的手段。

Abstract: [Objective]: The objective of this study was to observe the clinical efficacy of ultrasound-guided intra-articular injection of hypertonic glucose in the treatment of knee osteoarthritis (KOA) and explore its mechanism. [Methods]: 56 patients with KOA were injected with Hypertonic dextrose (20%) 8 ml into the suprapatellar bursa under the guidance of ultrasound, once every 2 weeks for three times. The changes of VAS score, WOMAC index and 40 m walking time were observed before treatment and 2, 4, 8 weeks after treatment. [Results]: The VAS score, WOMAC index and 40 m walking time of KOA patients at 2, 4 and 8 weeks after treatment were significantly lower than those before treatment (P < 0.05), the difference was statistically significant. [Conclusion]: Ultrasound-guided intra-articular injection of hypertonic glucose can effectively relieve pain and improve knee joint function in patients with KOA. It can be a safe and effective method for clinical treatment of knee osteoarthritis pain.