幽门螺杆菌与肝硬化相关并发症相关性研究
Correlation between Helicobacter pylori and Complications of Liver Cirrhosis
摘要: 肝硬化是各种慢性肝病的终末阶段，其并发症有消化道出血、肝性脑病(Hepatic encephalopathy)、肝细胞癌(Hepatocellular carcinoma)等，发生率高，死亡风险大。越来越多研究指出幽门螺杆菌(HP)通过多种机制参与肝硬化疾病进展，增加了并发症发生率，及早检测和根除Hp可使肝硬化患者获益。本文通过介绍幽门螺杆菌相关致病机制和对肝硬化并发症的影响，为临床实践和科研工作提供参考。
Abstract: Cirrhosis is the final stage of various chronic liver diseases, and its complications include gastrointestinal bleeding, hepatic encephalopathy (HE), hepatocellular carcinoma (HCC) and so on, with high incidence and high risk of death. More and more studies indicate that Helicobacter pylori (HP) participates in the progression of liver cirrhosis through various mechanisms, which increases the incidence of complications. Early detection and eradication of HP can benefit patients with liver cirrhosis. In this paper, the pathogenic mechanism of Helicobacter pylori and its influence on complications of liver cirrhosis were introduced to provide reference for clinical practice and scientific research.
文章引用：陈思荣, 韩文, 郭晓娜. 幽门螺杆菌与肝硬化相关并发症相关性研究[J]. 临床医学进展, 2021, 11(11): 5327-5333. https://doi.org/10.12677/ACM.2021.1111787

参考文献

[1] Joanna, P., et al. (2017) Helicobacter pylori Infection among Patients with Liver Cirrhosis. European Journal of Gastroenterology & Hepatology, 29, 1161-1165.
[Google Scholar] [CrossRef] 
[2] 敦泽, 郭立芳. 幽门螺杆菌致病机制的研究进展[J]. 中国中西医结合消化杂志, 2020, 28(8): 645-648.
[3] 刘文忠, 等. 第五次全国幽门螺杆菌感染处理共识报告[J]. 胃肠病学, 2017, 22(6): 346-360.
[4] 罗晓明, 等. 幽门螺杆菌的感染现状和诊断治疗进展[J]. 江苏预防医学, 2019, 30(6): 646-649.
[5] 马卫娥, 肖劲. 成人幽门螺杆菌感染的现状及分析[J]. 中国实用医药, 2020, 15(28): 173-175.
[6] 张明伟, 等. 安徽中南部地区幽门螺杆菌流行病学调查[J]. 中华全科医学, 2020, 18(8): 1395-1398.
[7] Wang, J., et al. (2016) Helicobacter pylori Infection May Increase the Risk of Progression of Chronic Hepatitis B Disease among the Chinese Population: A Meta-Analysis. International Journal of Infectious Diseases, 50, 30-37.
[Google Scholar] [CrossRef] [PubMed]
[8] 侯军良, 张新元, 贾彦生, 宁更献, 刘先锻. 肝病患者幽门螺杆菌感染的临床分析[J]. 河北医科大学学报, 2005, 26(6): 323-324.
[9] 朱春霞, 王伯军, 秦丽君. 肝性脑病与幽门螺杆菌感染的关系[J]. 现代实用医学, 2011, 23(2): 178-179+188.
[10] 赵改仙, 连红梅, 阎小宁. 幽门螺杆菌感染与肝硬化患者上消化道出血及肝性脑病的关系[J]. 海南医学, 2019, 30(21): 2755-2757.
[11] 曾胜澜, 等. 肝性脑病中肠道菌群的作用机制及治疗方法[J]. 临床肝胆病杂志, 2020, 36(10): 2375-2379.
[12] 张红伟, 李琼. 幽门螺杆菌感染与肝硬化肝性脑病发病的相关性分析[J]. 中国社区医师, 2016, 32(7): 62-63.
[13] 王炘, 詹志刚. 幽门螺杆菌感染与肝性脑病的相关性[J]. 胃肠病学和肝病学杂志, 2011, 20(12): 1097-1098.
[14] 刘小娇, 陈明锴. 门脉高压性胃病研究进展[J]. 中华消化内镜杂志, 2020, 37(10): 762-765.
[15] 尹昕茹, 陈东风. 肝硬化的胃肠道并发症[J]. 中华肝脏病杂志, 2020, 28(5): 377-380.
[16] 谌渐辉, 马林. 乙型肝炎肝硬化患者发生门脉高压性胃病出血相关因素分析[J]. 实用肝脏病杂志, 2017, 20(4): 431-434.
[17] Licinio, R., et al. (2016) Helicobacter pylori, Liver Cirrhosis, and Portal Hypertension: An Updated Appraisal. Immunopharmacology and Immunotoxicology, 38, 408-413.
[Google Scholar] [CrossRef] [PubMed]
[18] 张继承, 等. 幽门螺杆菌感染与肝硬化患者胃粘膜病变的相关性及其价值分析[J]. 中国煤炭工业医学杂志, 2019, 22(2): 161-165.
[19] 王文生, 等. 幽门螺杆菌感染与门静脉高压性胃病关系的meta分析[J]. 胃肠病学, 2019, 24(11): 671-677.
[20] 黄妙灵, 刘序友. 肝炎后肝硬化胃肠激素水平及与幽门螺杆菌感染相关性分析[J]. 新医学, 2020, 51(1): 37-41.
[21] 温小凤. 幽门螺杆菌感染与肝纤维化程度相关性研究[Z].
[22] Goo, M., et al. (2009) Helicobacter pylori Promotes Hepatic Fibrosis in the Animal Model. Laboratory Investigation, 89, 1291-1303.
[Google Scholar] [CrossRef] [PubMed]
[23] Ki, M., et al. (2010) Helicobacter pylori Accelerates Hepatic Fibrosis by Sensitizing Transforming Growth Factor-β 1-Induced Inflammatory Signaling. Laboratory Investigation, 90, 1507-1516.
[24] Sakamoto, Y., et al. (2013) Effect of Helicobacter pylori Infection on Esophagogastric Variceal Bleeding in Patients with Liver Cirrhosis and Portal Hypertension. Journal of Gastroenterology and Hepatology, 28, 1444-1449.
[Google Scholar] [CrossRef] [PubMed]
[25] 高鹏, 刘敏, 周永宁. 结节性胃炎与幽门螺杆菌的研究进展[J]. 世界华人消化杂志, 2015, 23(32): 5177-5183.
[26] Elsebaey, M.A., et al. (2019) Impact of Helicobacter pylori Infection on Gastric Variceal Bleeding among Patients with Liver Cirrhosis. Gastroenterology Research and Practice, 2019, Article ID: 6529420.
[Google Scholar] [CrossRef] [PubMed]
[27] 张鸣, 等. 肝硬化并发症与幽门螺杆菌感染的相关性研究[J]. 陕西医学杂志, 2017, 46(12): 1664-1665.
[28] 何永康, 袁雪梅. 乙型肝炎肝硬化合并上消化道出血与幽门螺杆菌感染关系的临床研究[J]. 中西医结合肝病杂志, 2017, 27(5): 272-275.
[29] 李钰伶, 等. 幽门螺杆菌感染与HBV相关肝硬化常见死亡原因的关系[J]. 临床肝胆病杂志, 2015, 31(9): 1439-1443.
[30] 贾昊鹍, 王正根. 肝源性溃疡的发病机制与药物治疗[J]. 中南医学科学杂志, 2017, 45(2): 201-203.
[31] 乔冠恩, 等. 肝源性溃疡与幽门螺杆菌关系研究[J]. 中国实用医药, 2020, 15(12): 23-25.
[32] 杨铁军, 张东锋, 胡涛. 肝源性溃疡与幽门螺杆菌感染的相关性临床研究[J]. 中华医院感染学杂志, 2015, 25(16): 3667-3668+3671.
[33] 臧立娜. 肝硬化并发门静脉血栓研究进展[J]. 实用肝脏病杂志, 2014, 17(4): 429-432.
[34] Ahmed, A., et al. (2020) Helicobacter pylori as an Initiating Factor of Complications in Patients with Cirrhosis: A Single-Center Observational Study. Frontiers in Medicine, 7, 96.
[Google Scholar] [CrossRef] [PubMed]
[35] Ponzetto, A. and Holton, J. (2019) The Management of Portal Vein Thrombosis. European Journal of Gastroenterology & Hepatology, 31, 547.
[Google Scholar] [CrossRef] 
[36] Popescu, D., Andronescu, D. and Babes, P.A. (2018) The Association between Helicobacter pylori Infection and Liver and Biliary Tract Disorders. Current Health Sciences Journal, 44, 186-191.

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