利拉鲁肽改善肥胖的研究进展
Research Progress of Liraglutide in Improving Obesity
DOI: 10.12677/ACM.2021.1111814, PDF,   
作者: 邢国庆:滨州医学院,山东 滨州;于苏国*:滨州医学院附属医院,山东 滨州
关键词: 利拉鲁肽肥胖体重降低Liraglutide Obesity Weight Loss
摘要: GLP-1 (胰高血糖素样肽)是一种与胰高血糖素相同的蛋白质前体,糖尿病合并肥胖患者体内表达的GLP-1较正常人多,因此,GLP-1是近年来治疗糖尿病合并肥胖的新靶点,研究发现,其对于不伴有糖尿病的肥胖患者也有较好的收益。针对此靶点而研制的GLP-1类似物是一种非胰岛素依赖性的新型的降糖药物,且其可通过延缓胃排空,抑制食欲、提高组织对于胰岛素的敏感性等达到降脂的作用。其中,利拉鲁肽是一种高活性、高选择性的GLP-1类似物,本文重点以利拉鲁肽对改善肥胖症及相关并发症的研究进展进行综述。
Abstract: GLP-1 (glucagon like peptide) is a protein precursor similar to glucagon. GLP-1 is more common in obese diabetic patients than in normal persons. Therefore, GLP-1 is a new target for treating diabetes and obesity in recent years. It is found that it has a good benefit for obese patients without diabetes. GLP-1 analogue developed for this target is a new non insulin dependent hypoglycemic drug, and it can reduce fat by delaying gastric emptying, inhibiting appetite and improving tissue sensitivity to insulin. Liraglutide is a highly active and selective GLP-1 analogue. This paper focuses on the research progress of liraglutide in improving obesity and related complications.
文章引用:邢国庆, 于苏国. 利拉鲁肽改善肥胖的研究进展[J]. 临床医学进展, 2021, 11(11): 5501-5506. https://doi.org/10.12677/ACM.2021.1111814

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