托吡卡胺所致的睫状肌麻痹对高度近视患者眼球生物学测量的影响

Effect of Cycloplegia Induced by Tropicamide on Ocular Biometry in Patients with High Myopia

摘要: 目的：研究托吡卡胺滴眼液所致的睫状肌麻痹前后成人高度近视患者眼球生物学参数的变化。方法：选取25例(47眼)成人高度近视患者，0.5%托吡卡胺滴眼麻痹睫状肌，睫状肌麻痹前后用IOL-Master700测量角膜曲率(flat keratometry, FK; steep keratometry, SK)、中央角膜厚度(central corneal thickness, CCT)、前房深度(anterior chamber depth, ACD)、晶状体厚度(lens thickness, LT)和眼轴(axial length, AL)，分析睫状肌麻痹前后各参数的变化。结果：角膜曲率(FK, SK)：用药前后差异无统计学意义(均P > 0.05)；中央角膜厚度(CCT)：用药后增加约3 um，差异有统计学意义(P < 0.05)；前房深度(ACD)：用药后增加约0.06 mm，差异有统计学意义(P < 0.05)；晶状体厚度(LT)：用药后减少约0.02 mm，差异有统计学意义(P < 0.05)；眼轴(AL)：用药后减少约0.007 mm，差异有统计学意义(P < 0.05)。结论：睫状肌麻痹剂托吡卡胺，对成人高度近视患者，不影响K值、但可致CCT增厚、ACD增加、LT变薄，AL减少。

Abstract: Objective: To investigate the changes of ocular biometry before and after cycloplegia induced by tropicamide in high myopia patients. Methods: Twenty-five high myopia patients (47 eyes) were selected, cycloplegia was induced by 0.5% tropicamide. Keratometry (flat keratometry, FK; steep keratometry, SK), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT) and axial length (AL) were measured with IOL-Master700. The changes of parameters before and after cycloplegia were analyzed. Results: The K (FK/SK) was no significant difference (both P > 0.05). After cycloplegia, CCT increased about 3 um, ACD increased about 0.06 mm, the differences were statistically significant (both P < 0.05); LT decreased about 0.02 mm, AL decreased about 0.007 mm, the differences were statistically significant (both p < 0.05). Conclusion: In high myopia patients, tropicamide had no effect on K, but may cause a significant increase in CCT and ACD, and a significant decrease in LT and AL.