原发部位手术在远处转移的四肢软组织肉瘤患者中的作用

The Role of Primary Site Surgery in Patients with Distant Metastatic Soft Tissue Sarcoma of the Extremities

摘要: 目的：研究原发部位手术能否改善远处转移的四肢软组织肉瘤患者的预后。方法：本研究选取2010~2015年SEER数据库远处转移的四肢软组织肉瘤患者数据。利用倾向评分匹配评分平衡手术和未手术患者之间的差异。采用Kaplan-Meier法研究各组件患者的预后差异，均采用log-rank检验进行统计分析。结果：8331例患者被纳入本研究。生存分析结果表明原发部位手术可显著改善远处转移的四肢软组织肉瘤患者的预后，而保肢和截肢两种术式对远处转移的四肢软组织肉瘤患者预后无影响。结论：原发部位手术可显著改善远处转移的四肢软组织肉瘤患者的预后。

Abstract: Objective: To investigate whether primary tumor surgery can improve the prognosis of patients with distant metastatic soft tissue sarcoma of the extremities. Methods: Data of patients with distant metastases of soft tissue sarcoma of extremities from 2010 to 2015 were selected from SEER database. Propensity score matching scores were used to balance differences between surgical and non-surgical patients. Kaplan-Meier method was used to study the difference in prognosis of each group of patients, and log-rank test was used for statistical analysis. Results: A total of 8331 patients were enrolled in this study. Survival analysis showed that primary site surgery significantly improved the prognosis of patients with distant metastatic soft tissue sarcoma of the extremities, while limb salvage and amputation had no effect on the prognosis of patients with distant metastatic soft tissue sarcoma of the extremities. Conclusion: Primary site surgery significantly improved the prognosis of patients with distant metastatic soft tissue sarcomas of the extremities.