SII、FAR及CA125水平与子宫内膜癌临床病理特征的关系

Relation between the Levels of SII, FAR, CA125 and Clinicopathological Features of Endometrial Carcinoma

摘要: 目的：评估系统免疫炎症指数(SII)、纤维蛋白原、白蛋白比值(FAR)及CA125水平与子宫内膜癌临床病理特征的相关性。方法：回顾分析2021年1月至2021年10月于青岛市市立医院行子宫内膜癌分期手术治疗的子宫内膜癌患者的临床资料，收集其术前检测的血常规、凝血常规、肝肾功、肿瘤标志物等结果，并通过中性粒细胞术(N)、淋巴细胞数(L)、血小板数(PLT)、纤维蛋白原(Fib)、白蛋白(Alb)，计算得出SII (血小板数 × 中性粒细胞数/淋巴细胞数)、FAR (纤维蛋白原/白蛋白)，并根据不同临床病理特征将患者进行相应分组(包括病理类型、组织学分级、手术–病理分期、肌层浸润深度、脉管浸润、宫颈累及、宫体外转移及淋巴结转移情况)，比较不同临床病理特征下SII、FAR、CA125水平的差异。结果：SII在不同手术–病理分期、肌层浸润深度、宫体外转移及淋巴结转移分组中，差异有统计学意义(P < 0.05)；FAR在不同病理类型、手术–病理分期、肌层浸润深度、宫体外转移及淋巴结转移分组中，差异有统计学意义(P < 0.05)；CA125在不同手术–病理分期、脉管浸润、宫体外转移及淋巴结转移分组中，差异有统计学意义(P < 0.05)。结论：SII、FAR及CA125可对子宫内膜癌患者肌层浸润深度、宫体外及淋巴结转移等具有一定的预测价值。

Abstract: Objective: To evaluate the correlation between systemic immune inflammation index (SII), fibrinogen albumin ratio (FAR), CA125 and clinicopathological features of endometrial carcinoma. Methods: The clinical data of endometrial cancer patients who underwent staged surgery for endometrial cancer in Qingdao Municipal Hospital from January 2021 to October 2021 were retrospectively analyzed. The results of blood routine, coagulation routine, liver and kidney function, tumor markers and so on were collected, and the results were analyzed by neutropenia (N), lymphocyte number (L), platelet number (PLT), fibrinogen (Fib) Albumin (Alb), calculated SII (plateletscount × neutrophil count/lymphocyte count), FAR (fibrinogen/albumin), and the patients were divided into groups according to different clinicopathological characteristics (including pathological type, histological grade, operation pathological stage, depth of myometrial infiltration, vascular infiltration, cervical involvement, extrauterine metastasis and lymph node metastasis), to compare the levels of SII, FAR and CA125 under different clinicopathological features. Results: There were significant differences in SII in different surgical pathological stages, depth of myometrial invasion, extrauterine metastasis and lymph node metastasis (P < 0.05); There were significant differences in FAR in different pathological types, surgical pathological stages, depth of myometrial invasion, extrauterine metastasis and lymph node metastasis (P < 0.05); There were significant differences in CA125 in different surgical pathological stages, vascular infiltration, extrauterine metastasis and lymph node metastasis (P < 0.05). Conclusion: SII, FAR and CA125 can predict the depth of myometrial invasion, extrauterine and lymph node metastasis in patients with endometrial cancer.