亚临床甲状腺功能减退与糖尿病肾病的关系研究进展
Advances in the Relationship between Subclinical Hypothyroidism and Diabetic Nephropathy
摘要: 糖尿病肾病(DKD)是糖尿病最常见的微血管并发症之一，也是终末期肾病(ESRD)的主要病因。近年来研究表明亚临床甲状腺功能减退症与糖尿病肾病相关，且有研究表明甲状腺激素替代治疗可减轻蛋白尿排泄、改善肾功能；因此，现就亚临床甲状腺功能减退症与糖尿病肾病的关系进行描述。
Abstract: Diabetic nephropathy (DKD) is one of the most common microvascular complications of diabetes and the main cause of end-stage renal disease (ESRD). In recent years, studies have shown that subclinical hypothyroidism is associated with diabetic nephropathy, and studies have shown that thyroid hormone replacement therapy can reduce protein urine excretion and improve kidney function. Therefore, the relationship between subclinical hypothyroidism and diabetic nephropathy is described.
文章引用：沈小雅, 张永莉. 亚临床甲状腺功能减退与糖尿病肾病的关系研究进展[J]. 临床医学进展, 2021, 11(12): 5995-5999. https://doi.org/10.12677/ACM.2021.1112888

参考文献

[1] Holt, R.I.G. (2018) Lest We Forget the Microvascular Complications of Diabetes. Diabetic Medicine, 35, 1307. [Google Scholar] [CrossRef] [PubMed]
[2] Jiang, G., Luk, A.O.Y., Tam, C.H.T., et al. (2019) Progression of Diabetic Kidney Disease and Trajectory of Kidney Function Decline in Chinese Patients with Type 2 Diabetes. Kidney International, 95, 178-187. [Google Scholar] [CrossRef] [PubMed]
[3] Han, C., He, X., Xia, X., et al. (2015) Subclinical Hypothyroidism and Type 2 Diabetes: A Systematic Review and Meta-Analysis. PLoS ONE, 10, e0135233. [Google Scholar] [CrossRef] [PubMed]
[4] Udovcic, M., Pena, R.H., Patham, B., Tabatabai, L. and Kansara, A. (2017) Hypothyroidism and the Heart. Methodist DeBakey Cardiovascular Journal, 13, 55-59. [Google Scholar] [CrossRef] [PubMed]
[5] Qi, Q., Zhang, Q.M., Li, C.J., et al. (2017) Association of Thyroid-Stimulating Hormone Levels with Microvascular Complications in Type 2 Diabetes Patients. Medical Science Monitor, 23, 2715-2720. [Google Scholar] [CrossRef] 
[6] Wang, J., Li, H., Tan, M., et al. (2019) Association between Thyroid Function and Diabetic Nephropathy in Euthyroid Subjects with Type 2 Diabetes Mellitus: A Cross-Sectional Study in China. Oncotarget, 10, 88-97. [Google Scholar] [CrossRef] [PubMed]
[7] Iglesias, P., Bajo, M.A., Selgas, R. and Díez, J.J. (2017) Thyroid Dysfunction and Kidney Disease: An Update. Reviews in Endocrine and Metabolic Disorders, 18, 131-144. [Google Scholar] [CrossRef] [PubMed]
[8] Mendoza, A. and Hollenberg, A.N. (2017) New Insights into Thyroid Hormone Action. Pharmacology & Therapeutics, 173, 135-145. [Google Scholar] [CrossRef] [PubMed]
[9] Liu, P., Liu, R., Chen, X., Chen, Y., Wang, D., Zhang, F. and Wang, Y. (2015) Can Levothyroxine Treatment Reduce Urinary Albumin Excretion Rate in Patients with Early Type 2 Diabetic Nephropathy and Subclinical Hypothyroidism? A Randomized Double-Blind and Placebo-Controlled Study. Current Medical Research and Opinion, 31, 2233-2240. [Google Scholar] [CrossRef] [PubMed]
[10] Furukawa, S., Yamamoto, S., Todo, Y., et al. (2014) Association between Subclinical Hypothyroidism and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus. Endocrine Journal, 61, 1011-1018. [Google Scholar] [CrossRef] 
[11] Haro, J.M., Sabio, J.M. and Vargas, F. (1992) Renal Beta-Adrenoceptors in Thyroxine-Treated Rats. Journal of Endocrinological Investigation, 15, 605-608. [Google Scholar] [CrossRef] 
[12] Hager, M.R., Narla, A.D. and Tannock, L.R. (2017) Dyslipidemia in Patients with Chronic Kidney Disease. Reviews in Endocrine and Metabolic Disorders, 18, 29-40. [Google Scholar] [CrossRef] [PubMed]
[13] Shin, D.J. and Osborne, T.F. (2003) Thyroid Hormone Regulation and Cholesterol Metabolism Are Connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2). Journal of Biological Chemistry, 278, 34114-34118. [Google Scholar] [CrossRef] 
[14] Fazaeli, M., Khoshdel, A., Shafiepour, M. and Rohban, M. (2019) The Influence of Subclinical Hypothyroidismon Serum Lipid Profile, PCSK9 Levels and CD36 Expression on Monocytes. Diabetology & Metabolic Syndrome, 13, 312-316. [Google Scholar] [CrossRef] [PubMed]
[15] Delitala, A.P., Fanciulli, G., Maioli, M. and Delitala, G. (2017) Subclinical Hypothyroidism, Lipid Metabolism and Cardiovascular Disease. European Journal of Internal Medicine, 38, 17-24. [Google Scholar] [CrossRef] [PubMed]
[16] Lekakis, J., Papamichael, C., Alevizaki, M., et al. (1997) Flow-Mediated, Endothelium-Dependent Vasodilation Is Impaired in Subjects with Hypothyroidism, Borderline Hypothyroidism, and High-Normal Serum Thyrotropin (TSH) Values. Thyroid, 7, 411-414. [Google Scholar] [CrossRef] [PubMed]
[17] Taddei, S., Caraccio, N., Virdis, A., et al. (2006) Low-Grade Systemic Inflammation Causes Endothelial Dysfunction in Patients with Hashimoto’s Thyroiditis. The Journal of Clinical Endocrinology & Metabolism, 91, 5076-5082. [Google Scholar] [CrossRef] [PubMed]
[18] 杨云潇, 张铭. 甲状腺功能减退症与动脉粥样硬化的研究新进展[J]. 中国动脉硬化杂志, 2021, 29(6): 489-493.
[19] Vicinanza, R., Cappotelli, G., Malacrino, C., Nardo, T., Buchetti, B., Lenti, L., Celi, F.S. and Scarpa, S. (2013) Oxidized Low-Density Lipoproteins Impair Endothelial Function by Inhibiting Non-Genomic Action of Thyroid Hormone-Mediated Nitric Oxide Production in Human Endothelial Cells. Thyroid, 23, 231-238. [Google Scholar] [CrossRef] [PubMed]
[20] Alibaz Oner, F., Yurdakul, S., Oner, E., Kubat Uzum, A. and Erguney, M. (2011) Evaluation of the Effect of L-Thyroxin Therapy on Endothelial Functions in Patients with Subclinical Hypothyroidism. Endocrine, 40, 280-284. [Google Scholar] [CrossRef] [PubMed]
[21] Brenta, G. (2011) Why Can Insulin Resistance Be a Natural Consequence of Thyroid Dysfunction? Journal of Thyroid Research, 2011, Article ID: 152850. [Google Scholar] [CrossRef] [PubMed]
[22] Vyakaranam, S., Vanaparthy, S., Nori, S., Palarapu, S. and Bhongir, A.V. (2014) Study of Insulin Resistance in Subclinical Hypothyroidism. International Journal of Health Sciences and Research, 4, 147-153.
[23] Cettour-Rose, P., Theander-Carrillo, C., Asensio, C., et al. (2005) Hypothyroidism in Rats Decreases Peripheral Glucose Utilization, a Defect Partially Corrected by Central Leptin Infusion. Diabetologia, 48, 624-633. [Google Scholar] [CrossRef] [PubMed]
[24] 张晨钰. 2型糖尿病伴亚临床甲减患者胰岛素抵抗以及相关因素分析[D]: [硕士学位论文]. 沈阳: 中国医科大学, 2020.
[25] Shin, D.H., Lee, M.J., Lee, H.S., et al. (2013) Thyroid Hormone Replacement Therapy Attenuates the Decline of Renal Function in Chronic Kidney Disease Patients with Subclinical Hypothyroidism. Thyroid, 23, 654-661. [Google Scholar] [CrossRef] [PubMed]
[26] Bajaj, S., Purwar, N., Gupta, A., Gupta, P. and Srivastava, A. (2016) Prevalence of Hypothyroidism in Diabetic Kidney Disease and Effect of Thyroid Hormone Replacement on Estimate Glomerular Filtration Rate. Indian Journal of Endocrinology and Metabolism, 20, 795-798. [Google Scholar] [CrossRef] [PubMed]
[27] Basu, G. and Mohapatra, A. (2012) Interactions between Thyroid Disorders and Kidney Disease. Indian Journal of Endocrinology and Metabolism, 16, 204-213. [Google Scholar] [CrossRef] [PubMed]

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