糖尿病肾病PTH及FT3与显性蛋白尿的相关性

Correlation between PTH, FT3 and Dominant Proteinuria in Diabetic Kidney Disease

摘要: 目的：糖尿病及糖尿病肾病发病率日益提升，糖尿病肾病为终末期肾病的重要发病因素，且糖尿病肾病首先表现为尿白蛋白排泄增加。本文研究PTH及FT3与显性蛋白尿的关系。方法：选择2019~2020于青岛大学附属医院住院治疗的糖尿病肾病患者，共514位，根据尿蛋白排泄分为微量蛋白尿组(随机UACR 30~300 mg/g)，共322位患者；显性蛋白尿组(随机UACR > 300 mg/g)，共192位。应用Logistic回归分析PTH及FT3与显性蛋白尿的关系。结果：二元Logistic回归提示PTH及FT3为显性蛋白尿的危险因素，PTH (OR = 1.012，p = 0.002)、FT3 (OR = 0.718，p = 0.017)。结论：PTH及FT3为显性蛋白尿的危险因素，PTH升高及FT3降低对蛋白尿增加具有早期提示意义。

Abstract: Objective: The incidence of diabetes and diabetic kidney disease is increasing day by day. Diabetic kidney disease is an important factor in the pathogenesis of end-stage renal disease, and diabetic kidney disease is first manifested as increased urinary albumin excretion. This article studies the relationship between PTH, FT3 and dominant proteinuria. Methods: A total of 514 patients with diabetic kidney disease who were hospitalized in the Affiliated Hospital of Qingdao University from 2019 to 2020 were selected and divided into the microalbuminuria group (random UACR 30~300 mg/g) according to urine protein excretion, a total of 322 patients; dominant proteinuria group (Random UACR > 300 mg/g), 192 digits in total. Logistic regression was used to analyze the relationship between PTH, FT3 and dominant proteinuria. Results: Binary Logistic regression indicated that PTH and FT3 were risk factors for dominant proteinuria, PTH (OR = 1.012, p = 0.002), FT3 (OR = 0.718, p = 0.017). Conclusion: PTH and free T3 are the risk factors for dominant proteinuria. The increase of PTH and the decrease of free T3 have early prompting significance for the increase of proteinuria.