米诺环素在幽门螺杆菌根除方案中的应用进展
Application Progress of Minocycline in Helicobacter pylori Eradication Program
DOI: 10.12677/ACM.2021.1112903, PDF,   
作者: 王 宁：济宁医学院临床医学院，山东 济宁；济宁市第一人民医院消化内科，山东 济宁；赵朕华, 孟庆顺*：济宁市第一人民医院消化内科，山东 济宁
关键词: 幽门螺杆菌；米诺环素；耐药率；治疗方案；Helicobacter pylori； Minocycline； Drug Resistance Rate； Therapeutic Schedule
摘要: 随着幽门螺杆菌感染率的不断提高，人们对幽门螺杆菌根除的重视度也逐渐提高。然而，抗生素的广泛应用使得幽门螺杆菌的耐药率增加，根除失败率升高。近年来，临床研究发现含米诺环素的根除方案在幽门螺杆菌的初次和补救治疗中有着较好的疗效。因此，合理应用含米诺环素的根除方案，对幽门螺杆菌的治疗有着深远意义。本文就米诺环素在幽门螺杆菌根除方案中的应用进展作一综述。
Abstract: With the continuous improvement of Helicobacter pylori infection, stress of Helicobacter pylori eradication is also gradually improved. However, the widespread use of antibiotics that leads to increased prevalence of Helicobacter pylori resistance. In recent years, the eradication of higher failure rate clinical studies have found that contain minocycline scheme in Helicobacter pylori eradication in first and remedial treatment have good curative effect. Therefore, the rational application of minocycline in the eradication of Helicobacter pylori has far-reaching significance. This paper reviews the application of minocycline in the eradication of Helicobacter pylori.
文章引用：王宁, 赵朕华, 孟庆顺. 米诺环素在幽门螺杆菌根除方案中的应用进展[J]. 临床医学进展, 2021, 11(12): 6093-6096. https://doi.org/10.12677/ACM.2021.1112903

参考文献

[1] Sugano, K., Tack, J., Kuipers, E.J., et al. (2015) Kyoto Global Consensus Report on Helicobacter pylori Gastritis. Gut, 64, 1353-1367. [Google Scholar] [CrossRef] [PubMed]
[2] Malfertheiner, P., Megraud, F., O’Morain, C.A., et al. (2017) Management of Helicobacter pylori Infection—The Maastricht V/Florence Consensus Report. Gut, 66, 6-30. [Google Scholar] [CrossRef] [PubMed]
[3] Bray, F., Ferlay, J., Soerjomataram, I., et al. (2018) Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424. [Google Scholar] [CrossRef] [PubMed]
[4] 李兆申, 吕农华, 周丽雅. 中国幽门螺杆菌根除与胃癌防控的专家共识意见(2019年, 上海) [J]. 中华健康管理学杂志, 2019, 13(4): 285-291.
[5] Burucoa, C. and Axon, A. (2017) Epidemiology of Helicobacter pylori Infection. Helicobacter, 22, e12403. [Google Scholar] [CrossRef] [PubMed]
[6] 刘文忠, 等. 第五次全国幽门螺杆菌感染处理共识报告[J]. 胃肠病学, 2017, 22(6): 346-360.
[7] 文学琴, 谷俊莹, 陈峥宏. 幽门螺杆菌对四环素耐药的机制研究进展[J]. 中国抗生素杂志, 2020, 45(6): 545-550.
[8] Zhang, L., Lan, Y., Wang, Q., et al. (2019) Application of Minocycline-Containing Bismuth Quadruple Therapies as First-Line Regimens in the Treatment of Helicobacter pylori. Gastroenterology Research and Practice, 2019, Article ID: 9251879. [Google Scholar] [CrossRef] [PubMed]
[9] 徐淑兰, 洪卫康, 宣世海. 含米诺环素的四联治疗方案作为一线和二线方案根治幽门螺杆菌感染的研究[J]. 现代消化及介入诊疗, 2019, 24(10): 1133-1136.
[10] 蒲宁, 卡世会, 汤志刚. 雷贝拉唑/米诺环素/阿莫西林/铋剂方案作为一、二线方案根除幽门螺杆菌的疗效[J]. 中国老年学杂志, 2018, 38(23): 5713-5715.
[11] Graham, D.Y. and Dore, M.P. (2016) Helicobacter pylori Therapy: A Paradigm Shift. Expert Review of Anti-Infective Therapy, 14, 577-585. [Google Scholar] [CrossRef] [PubMed]
[12] Savoldi, A., Carrara, E., Graham, D.Y., et al. (2018) Prevalence of Antibiotic Resistance in Helicobacter pylori: A Systematic Review and Meta-Analysis in World Health Organization Regions. Gastroenterology, 155, 1372-1382. [Google Scholar] [CrossRef] [PubMed]
[13] Murakami, K., Sato, R., Okimoto, T., et al. (2006) Effectiveness of Minocycline-Based Triple Therapy for Eradication of Helicobacter pylori Infection. Gastroenterology & Hepatology, 21, 262-267. [Google Scholar] [CrossRef] [PubMed]
[14] Song, Z.Q. and Zhou, L.Y. (2016) Esomeprazole, Minocycline, Metronidazole and Bismuth as First-Line and Second-Line Regimens for Helicobacter pylori Eradication. Digital Distribution, 17, 260-267. [Google Scholar] [CrossRef] [PubMed]
[15] Song, Z., Suo, B., Zhang, L., et al. (2016) Rabeprazole, Minocycline, Amoxicillin, and Bismuth as First-Line and Second-Line Regimens for Helicobacter pylori Eradication. Helicobacter, 21, 462-470. [Google Scholar] [CrossRef] [PubMed]
[16] Ierardi, E., Giangaspero, A., Losurdo, G., et al. (2014) Quadruple Rescue Therapy after First and Second Line Failure for Helicobacter pylori Treatment: Comparison between Two Tetracycline-Based Regimens. Journal of Gastrointestinal and Liver Diseases, 23, 367-370. [Google Scholar] [CrossRef] [PubMed]
[17] Nakajima, S., Inoue, H., Inoue, T., et al. (2012) Multiple-Antibiotic-Resistant Helicobacter pylori Infection Eradicated with a Tailor-Made Quadruple Therapy. Gastroenterology & Hepatology, 27, 108-111. [Google Scholar] [CrossRef] [PubMed]
[18] 李梦迪, 王梓楠, 郑松柏. 含利福布汀 + 呋喃唑酮的三联方案与含米诺环素 + 呋喃唑酮的四联方案根除难治性幽门螺杆菌感染的疗效和安全性[J]. 中华消化杂志, 2019, 2019(12): 812-816.

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