显影材料在外科疝修补中的应用及进展
Application and Progress of Imaging-Visible Materials in Surgical Hernia Repair
DOI: 10.12677/NAT.2022.121001, PDF,   
作者: 丁绪忠, 柳安宁, 徐 宇:南通大学研究生院,江苏 南通;曹 庆, 李 鹏*:南通大学附属医院胃肠外科,江苏 南通;杨宇民:南通大学教育部/江苏省神经再生重点实验室/神经再生协同创新中心,江苏 南通
关键词: 疝气补片显影材料可视化 Hernia Meshes Imaging-Visible Materials Visualisation
摘要: 补片植入已经成为外科疝修补术的主流。与传统的有张力的手术修补方法相比,补片植入极大地加强了缺损腹壁强度,降低了复发率,但同时会带来一些补片相关并发症,如慢性异物反应(FBR)、腹腔粘连、感染以及瘘的发生。研究表明,这些并发症的发生与补片的挛缩移位密切相关,然而现有的影像学手段很难追踪这一过程,导致迫切需要开发一种与人体具有良好相容性并可在影像学下观察到的补片。本文介绍了常见显影材料在疝修补应用中的安全性及可视化的进展。
Abstract: The use of meshes has become the mainstay of surgical hernia repair. Compared to traditional tensioned surgical repair methods, mesh implantation has greatly enhanced the strength of the defective abdominal wall and reduced the recurrence rate, but at the same time, brings about some mesh-related complications, such as chronic foreign body reaction (FBR), abdominal adhesions, infection, and fistula development. Studies have shown that the occurrence of these complications is closely related to contracture and displacement of the mesh, yet available imaging tools do not track this process, leading to an urgent need to develop a mesh that is compatible with the body and can be observed on imaging. This article presents advances in the safety and visualization of common developing materials for hernia repair applications.
文章引用:丁绪忠, 曹庆, 柳安宁, 徐宇, 杨宇民, 李鹏. 显影材料在外科疝修补中的应用及进展[J]. 纳米技术, 2022, 12(1): 1-7. https://doi.org/10.12677/NAT.2022.121001

参考文献

[1] Kingsnorth, A. and LeBlanc, K. (2003) Hernias: Inguinal and Incisional. The Lancet, 362, 1561-1571. [Google Scholar] [CrossRef
[2] Lau, B., et al. (2012) Obesity Increases the Odds of Ac-quiring and Incarcerating Noninguinal Abdominal Wall Hernias. The American Surgeon, 78, 1118-1121. [Google Scholar] [CrossRef
[3] Collaboration, E.U.H.T. (2000) Mesh Compared with Non-Mesh Methods of Open Groin Hernia Repair: Systematic Review of Randomized Controlled Trials. British Journal of Surger, 87, 854-859.
[4] Seker, D. and Kulacoglu, H. (2011) Long-Term Complications of Mesh Repairs for Ab-dominal-Wall Hernias. Journal of Long-Term Effects of Medical Implants, 21, 205-218.
[5] Rakic, S. and LeBlanc, K.A. (2013) The Radiologic Appearance of Prosthetic Materials Used in Hernia Repair and a Recommended Classifica-tion. American Journal of Roentgenology, 201, 1180-1183. [Google Scholar] [CrossRef
[6] Bringman, S., et al. (2010) Hernia Repair: The Search for Ideal Mesh-es. Hernia, 14, 81-87. [Google Scholar] [CrossRef] [PubMed]
[7] Earle, D.B. and Mark, L.A. (2008) Prosthetic Material in Inguinal Hernia Repair: How Do I Choose? Surgical Clinics of North America, 88, 179-201. [Google Scholar] [CrossRef] [PubMed]
[8] Junge, K., et al. (2012) Mesh Biocompatibility: Effects of Cellular Inflammation and Tissue Remodelling. Langenbeck’s Archives of Surgery, 397, 255-270. [Google Scholar] [CrossRef] [PubMed]
[9] Klinge, U., et al. (1999) Foreign Body Reaction to Meshes Used for the Repair of Abdominal Wall Hernias. European Journal of Surgery, 165, 665-673.
[10] Klosterhalfen, B., Junge, K. and Klinge, U. (2005) The Lightweight and Large Porous Mesh Concept for Hernia Repair. Expert Review of Medical Devices, 2, 103-117. [Google Scholar] [CrossRef] [PubMed]
[11] Williams, D.F. (2008) On the Mechanisms of Biocompatibility. Biomaterials, 29, 2941-2953. [Google Scholar] [CrossRef] [PubMed]
[12] Brown, C.N. and Finch, J.G. (2010) Which Mesh for Her-nia Repair? Annals of the Royal College of Surgeons of England, 92, 272-278. [Google Scholar] [CrossRef
[13] Cobb, W.S., et al. (2005) Normal Intraabdominal Pressure in Healthy Adults. Journal of Surgical Research, 129, 231-235. [Google Scholar] [CrossRef] [PubMed]
[14] Pott, P.P., et al. (2012) Mechanical Properties of Mesh Materials Used for Hernia Repair and Soft Tissue Augmentation. PLoS ONE, 7, e46978. [Google Scholar] [CrossRef] [PubMed]
[15] Deeken, C.R., et al. (2011) Physicomechanical Evaluation of Polypropylene, Polyester, and Polytetrafluoroethylene Meshes for Inguinal Hernia Repair. Journal of the American Col-lege of Surgeons, 212, 68-79. [Google Scholar] [CrossRef] [PubMed]
[16] Junge, K., et al. (2001) Elasticity of the Anterior Ab-dominal Wall and Impact for Reparation of Incisional Hernias Using Mesh Implants. Hernia, 5, 113-118. [Google Scholar] [CrossRef] [PubMed]
[17] 中华医学会外科学分会疝和腹壁外科学组, 中国医师协会外科医师分会疝和腹壁外科医师委员会. 成人腹股沟疝诊疗指南(2014年版) [J]. 中国实用外科杂志, 2014, 34(6): 484-486.
[18] Fischer, T., et al. (2007) Functional Cine MRI of the Abdomen for the Assessment of Implanted Synthet-ic Mesh in Patients after Incisional Hernia Repair: Initial Results. European Radiology, 17, 3123-3129. [Google Scholar] [CrossRef] [PubMed]
[19] Girish, G., et al. (2011) Usefulness of the Twinkling Artifact in Identifying Implanted Mesh after Inguinal Hernia Repair. Journal of Ultrasound in Medicine, 30, 1059-1065. [Google Scholar] [CrossRef] [PubMed]
[20] 唐兴华, 等. 硫酸钡制剂在消化道造影中的不良反应及并发症研究进展[J]. 中国全科医学, 2013, 16(21): 2536-2538.
[21] Pepiol, A., et al. (2011) A Highly Radiopaque Ver-tebroplasty Cement Using Tetraiodinated O-Carborane Additive. Biomaterials, 32, 6389-6398. [Google Scholar] [CrossRef] [PubMed]
[22] 张晗. 聚乙烯/硫酸钡纳米复合材料的制备和表征[D]: [硕士学位论文]. 天津: 天津理工大学, 2012.
[23] Choi, S.Y., et al. (2015) Bioabsorbable Bone Fixation Plates for X-Ray Imaging Diagnosis by a Radiopaque Layer of Barium Sulfate and Poly(Lactic-Co-Glycolic Acid). Journal of Bi-omedical Materials Research Part B: Applied Biomaterials, 103, 596-607. [Google Scholar] [CrossRef] [PubMed]
[24] Ginebra, M.P., et al. (2002) Mechanical Performance of Acrylic Bone Cements Containing Different Radiopacifying Agents. Biomaterials, 23, 1873-1882. [Google Scholar] [CrossRef
[25] Wimhurst, J.A., Brooks, R.A. and Rushton, N. (2001) The Effects of Particulate Bone Cements at the Bone-Implant Interface. The Journal of Bone and Joint Surgery, 83, 588-592.
[26] 马君志, 等. 防辐射粘胶短纤维的研制及性能分析[J]. 人造纤维, 2018, 48(6): 2-7.
[27] Li, H., et al. (2021) Visualization of Implanted Mesh in the Pelvic Reconstructive Surgery Using an X-Ray-Detectable Thread. Ar-chives of Gynecology and Obstetrics, 304, 965-973. [Google Scholar] [CrossRef] [PubMed]
[28] Orucoglu, H. and Cobankara, F.K. (2008) Effect of Unintentionally Extruded Calcium Hydroxide Paste Including Barium Sulfate as a Radiopaquing Agent in Treatment of Teeth with Periapical Lesions: Report of a Case. Journal of Endodontics, 34, 888-891.
[29] Li, X., et al. (2017) Clinical Observation of Adverse Drug Reactions to Non-Ionic Iodinated Contrast Media in Population with Underlying Diseases and Risk Factors. The British Journal of Radiology, 90, Article ID: 20160729. [Google Scholar] [CrossRef] [PubMed]
[30] 黄双, 等. 国内外造影剂的最新研究进展[J]. 中国药学杂志, 2010, 45(16): 1213-1217.
[31] Ballard, D.H., et al. (2018) 3D Printing of Surgical Hernia Meshes Impregnated with Contrast Agents: In Vitro Proof of Concept with Imaging Characteristics on Computed Tomography. 3D Printing in Medicine, 4, Article No. 13. [Google Scholar] [CrossRef] [PubMed]
[32] Kiran, S., et al. (2009) Synthesis and Characterization of Iodinat-ed Polyurethane with Inherent Radiopacity. Biomaterials, 30, 5552-5559. [Google Scholar] [CrossRef] [PubMed]
[33] Ghosh, P., et al. (2014) Chitosan Derivatives Cross-Linked with Iodinated 2,5-Dimethoxy-2,5-Dihydrofuran for Non-Invasive Imaging. ACS Applied Materials & In-terfaces, 6, 17926-17936. [Google Scholar] [CrossRef] [PubMed]
[34] Aubert-Viard, F., et al. (2015) Chitosan Fin-ishing Nonwoven Textiles Loaded with Silver and Iodide for Antibacterial Wound Dressing Applications. Biomedical Materials, 10, Article ID: 015023. [Google Scholar] [CrossRef] [PubMed]
[35] 黄亦成, 等. 镍钛合金在医疗领域应用研究进展[J]. 生物医学工程学进展, 2015, 36(3): 169-172.
[36] 吕建祎, 等. 环境致癌物诱导慢性炎症致肺癌发生发展的研究进展[J]. 生物化学与生物物理进展, 2014, 41(1): 41-51.
[37] Shemyatovsky, K.A., et al. (2020) Computed Tomography Options in the Evaluation of Hernia Repair Outcomes Using “Titanium Silk” Mesh Implants. Journal of Tissue Engi-neering and Regenerative Medicine, 14, 684-689. [Google Scholar] [CrossRef] [PubMed]
[38] Gallez, B. and Swartz, H.M. (2004) In Vivo EPR: When, How and Why? NMR in Biomedicine, 17, 223-225. [Google Scholar] [CrossRef] [PubMed]
[39] Kramer, N.A., et al. (2010) A Concept for Magnetic Resonance Visualiza-tion of Surgical Textile Implants. Investigative Radiology, 45, 477-483. [Google Scholar] [CrossRef
[40] Chen, L.Y., et al. (2017) MRI Visible Fe3O4 Polypropylene Mesh: 3D Reconstruction of Spatial Relation to Bony Pelvis and Neurovascular Structures. International Urogynecology Journal, 28, 1131-1138. [Google Scholar] [CrossRef] [PubMed]
[41] Guillaume, O., et al. (2012) Permanent Polymer Coating for in Vivo MRI Visualization of Tissue Reinforcement Prostheses. Macromolecular Bioscience, 12, 1364-1374. [Google Scholar] [CrossRef] [PubMed]
[42] 秦苗, 等. 氧化铁纳米颗粒在磁共振成像中的应用[J]. 化学进展, 2020, 32(9): 1264-1273.
[43] 贡雪芃, 等. 对比剂的临床应用及其不良反应[J]. 医药导报, 2015, 34(9): 1192-1195.
[44] Slabu, I., et al. (2012) Investigation of Superparamagnetic Iron Oxide Nanoparticles for MR-Visualization of Surgical Implants. Current Pharmaceutical Biotechnology, 13, 545-551. [Google Scholar] [CrossRef] [PubMed]
[45] Otto, J., et al. (2014) In Vivo MRI Visualization of Parastomal Mesh in a Porcine Model. Hernia, 18, 663-670. [Google Scholar] [CrossRef] [PubMed]
[46] Blanquer, S., et al. (2012) New Magnet-ic-Resonance-Imaging-Visible Poly(ε-Caprolactone)-Based Polyester for Biomedical Applications. Acta Biomaterialia, 8, 1339-13347. [Google Scholar] [CrossRef] [PubMed]