对乙酰氨基酚家兔体内药物动力学研究的实验教学改革

Experiment Teaching Reform of Pharmacokinetics of Acetaminophen in Rabbits

摘要: 对乙酰氨基酚家兔体内药物动力学研究是我校药学、中药学专业药物动力学课程主要实验内容之一。实验目的是让学生理解和掌握通过测定家兔血药浓度来计算药物药动学参数。现有的实验方法测得的血药浓度数据存在波动范围大等现象，导致实验结果不理想。笔者经过查阅文献、预实验，对实验方法进行了改进，改进后实验方法重现性、稳定性好，适合学生实验教学。

Abstract: The pharmacokinetics of Acetaminophen in rabbits is one of the important courses of pharmacokinetics in Pharmacy and Traditional Chinese Medicine major. It’s important for the students to understand and master how to get the pharmacokinetics parameters of drugs by determining the blood drug concentration. The blood drug concentration presented a large fluctuation range, leading to unsatisfactory experimental results. The author revised the experiment, determined a new way to take blood and improvement HPLC method. The experimental results showed good stability and reproducibility. It is suitable for students experiment teaching.