肠道菌群与痛风的相关性研究进展
Research Progress on the Relationship between Gut Microbiota and Gout
DOI: 10.12677/HJBM.2022.121006, PDF,   
作者: 王悦琦*, 杨 森, 万明霞, 冯传芮, 高秀峰#：四川大学华西基础医学与法医学院，四川 成都；李乔惠：南京农业大学，信息管理学院，江苏 南京
关键词: 肠道菌群；痛风；高尿酸血症；代谢产物；炎症；Gutmicrobiota； Gout； Hyperuricemia； Metabolites； Inflammation
摘要: 痛风作为一种代谢性疾病，严重地威胁人类健康。肠道菌群作为人类的第二基因组与人类疾病之间的相互关系逐渐被发现，痛风与肠道菌群的相关性也倍受研究者的关注。本文拟从痛风患者肠道菌群特点、肠道菌群及代谢产物与痛风的关系等多个方面探讨痛风的发病机制，为痛风的诊断和有效治疗以及预防提供依据。
Abstract: As a metabolic disease, gout threatens human health seriously. The gut microbiota, as the second human genome, has gradually been found to be related to human diseases. The correlation between gout and gut microbiota has also attracted much attention from researchers. This article intends to explore the pathogenesis of gout from the characteristics of gout patients’ intestinal flora, the relationship between gut microbiota, metabolites and gout, and provide a basis for the diagnosis, effective treatment and prevention of gout.
文章引用：王悦琦, 杨森, 李乔惠, 万明霞, 冯传芮, 高秀峰. 肠道菌群与痛风的相关性研究进展[J]. 生物医学, 2022, 12(1): 48-53. https://doi.org/10.12677/HJBM.2022.121006

参考文献

[1] Dalbeth, N., Choi, H.K., Joosten, L., et al. (2019) Gout. Nature Reviews Disease Primers, 5, Article No. 69. [Google Scholar] [CrossRef] [PubMed]
[2] Singh, J.A. and Gaffo, A. (2020) Gout Epidemiology and Comorbidities. Seminars in Arthritis and Rheumatism, 50, S11-S16. [Google Scholar] [CrossRef] [PubMed]
[3] Wang, H., Lu, Y., Yan, Y., et al. (2019) Promising Treatment for Type 2 Diabetes: Fecal Microbiota Transplantation Reverses Insulin Resistance and Impaired Islets. Frontiers in Cellular and Infection Microbiology, 9, Article No. 455. [Google Scholar] [CrossRef] [PubMed]
[4] Dehlin, M., Jacobsson, L. and Roddy, E. (2020) Global Epidemiology of Gout: Prevalence, Incidence, Treatment Patterns and Risk Factors. Nature Reviews Rheumatology, 16, 380-390. [Google Scholar] [CrossRef] [PubMed]
[5] Schwabe, R.F. and Greten, T.F. (2020) Gut Microbiome in HCC-Mechanisms, Diagnosis and Therapy. Journal of Hepatology, 72, 230-238. [Google Scholar] [CrossRef] [PubMed]
[6] Xing, S.C., Meng, D.M., Chen, Y., et al. (2015) Study on the Diversity of Bacteroides and Clostridium in Patients with Primary Gout. Cell Biochemistry and Biophysics, 71, 707-715. [Google Scholar] [CrossRef] [PubMed]
[7] Guo, Z., Zhang, J.C., Wang, Z.L., et al. (2016) Intestinal Microbiota Distinguish Gout Patients from Healthy Humans. Scientific Reports, 6, Article No. 20602. [Google Scholar] [CrossRef] [PubMed]
[8] Shao, T.J., Shao, L., Li, H.C., et al. (2017) Combined Signature of the Fecal Microbiome and Metabolome in Patients with Gout. Frontiers in Microbiology, 8, Article No. 268. [Google Scholar] [CrossRef] [PubMed]
[9] Yu, Y.R., Liu, Q.P., Li, H.C., et al. (2018) Alterations of the Gut Microbiome Associated with the Treatment of Hyperuricaemia in Male Rats. Frontiers in Microbiology, 9, Article No. 2233. [Google Scholar] [CrossRef] [PubMed]
[10] Mendez-Salazar, E.O., Vazquez-Mellado, J., Casimiro-Soriguer, C.S., et al. (2021) Taxonomic Variations in the Gut Microbiome of Gout Patients with and without Tophi Might Have a Functional Impact on Urate Metabolism. Molecular Medicine, 27, Article No. 50. [Google Scholar] [CrossRef] [PubMed]
[11] Chu, Y.L., Sun, S.L., Huang, R.Y., et al. (2021) Metagenomic Analysis Revealed the Potential Role of Gut Microbiome in Gout. npj Biofilms and Microbiomes, 7, Article No. 66. [Google Scholar] [CrossRef] [PubMed]
[12] Wang, P.X., Deng, X.R., Zhang, C.H., et al. (2020) Gut Microbiota and Metabolic Syndrome. Chinese Medical Journal, 133, 808-816. [Google Scholar] [CrossRef] 
[13] 聂秀玲. 长期果糖摄入与代谢综合征[J]. 国际内分泌代谢杂志, 2018, 38(5): 339-342.
[14] Bray, G.A. (2013) Energy and Fructose from Beverages Sweetened with Sugar or High-Fructose Corn Syrup Pose a Health Risk for Some People. Advances in Nutrition, 4, 220-225. [Google Scholar] [CrossRef] [PubMed]
[15] 黄胜男, 林志健, 张冰, 等. 高尿酸血症鹌鹑肠道菌群结构分析[J]. 中国实验动物学报, 2020, 28(1): 17-22.
[16] Wang, H.N., Mei, L., Deng, Y., et al. (2019) Lactobacillus brevis DM9218 Ameliorates Fructose-Induced Hyperuricemia through Inosine Degradation and Manipulation of Intestinal Dysbiosis. Nutrition, 62, 63-73. [Google Scholar] [CrossRef] [PubMed]
[17] Chiaro, T.R., Soto, R., Stephens, W.Z., et al. (2017) A Member of the Gut Mycobiota Modulates Host Purine Metabolism Exacerbating Colitis in Mice. Science Translational Medicine, 9, 380. [Google Scholar] [CrossRef] [PubMed]
[18] Li, M., Yang, D.B., Mei, L., et al. (2014) Screening and Characterization of Purine Nucleoside Degrading Lactic Acid Bacteria Isolated from Chinese Sauerkraut and Evaluation of the Serum Uric Acid Lowering Effect in Hyperuricemic Rats. PLoS ONE, 9, e105577. [Google Scholar] [CrossRef] [PubMed]
[19] Wu, Y., Ye, Z., Feng, P., et al. (2021) Limosilactobacillus fermentum JL-3 Isolated from “Jiangshui” Ameliorates Hyperuricemia by Degrading Uric Acid. Gut Microbes, 13, Article ID: 1897211. [Google Scholar] [CrossRef] [PubMed]
[20] Nigam, S.K. and Bhatnagar, V. (2018) The Systems Biology of Uric Acid Transporters. Current Opinion in Nephrology and Hypertension, 27, 305-313. [Google Scholar] [CrossRef] 
[21] Fujita, K. and Ichida, K. (2018) ABCG2 as a Therapeutic Target Candidate for Gout. Expert Opinion on Therapeutic Targets, 22, 123-129. [Google Scholar] [CrossRef] [PubMed]
[22] Wrigley, R., Phipps-Green, A.J., Topless, R.K., et al. (2020) Pleiotropic Effect of the ABCG2 Gene in Gout: Involvement in Serum Urate Levels and Progression from Hyperuricemia to Gout. Arthritis Research & Therapy, 22, Article No. 45. [Google Scholar] [CrossRef] [PubMed]
[23] Eckenstaler, R. and Benndorf, R.A. (2021) The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update. International Journal of Molecular Sciences, 22, Article No. 6678. [Google Scholar] [CrossRef] [PubMed]
[24] Hoque, K.M., Dixon, E.E., Lewis, R.M., et al. (2020) The ABCG2 Q141K Hyperuricemia and Gout Associated Variant Illuminates the Physiology of Human Urate Excretion. Nature Communications, 11, Article No. 2767. [Google Scholar] [CrossRef] [PubMed]
[25] Wang, Y., Lin, Z.J., Zhang, B., et al. (2017) Cichorium intybus L. Promotes Intestinal Uric Acid Excretion by Modulating ABCG2 in Experimental Hyperuricemia. Nutrition & Metabolism, 14, Article No. 38. [Google Scholar] [CrossRef] [PubMed]
[26] 周蓓蓓, 魏华. 高尿酸血症与肠道菌群的相关性[J]. 中华临床免疫和变态反应杂志, 2020, 14(1): 76-80.
[27] Luo, Q.H., Cheng, D.J., Huang, C., et al. (2019) Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats. Molecules, 24, Article No. 1139. [Google Scholar] [CrossRef] [PubMed]
[28] 金钗, 徐明智. 肠道菌群与高尿酸血症及痛风的相关性研究[J]. 中国微生态学杂志, 2019, 31(8): 980-984.
[29] Maslowski, K.M., Vieira, A.T., Ng, A., et al. (2009) Regulation of Inflammatory Responses by Gut Microbiota and Chemoattractant Receptor GPR43. Nature, 461, 1282-1286. [Google Scholar] [CrossRef] [PubMed]
[30] Vieira, A.T., Galvao, I., Macia, L.M., et al. (2017) Dietary Fiber and the Short-Chain Fatty Acid Acetate Promote Resolution of Neutrophilic Inflammation in a Model of Gout in Mice. Journal of Leukocyte Biology, 101, 275-284. [Google Scholar] [CrossRef] 
[31] Henson, M.A. (2021) Interrogation of the Perturbed Gut Microbiota in Gouty Arthritis Patients through in Silico Metabolic Modeling. Engineering in Life Sciences, 21, 489-501. [Google Scholar] [CrossRef] [PubMed]

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