血清脂联素水平与脑梗死后认知功能障碍的相关性分析

Correlation between Serum Adiponectin Level and Post-Stroke Cognitive Impairment

摘要: 目的：探讨血清脂联素水平与脑梗死后认知功能障碍(post-stroke cognitive impairment, PSCI)的相关性。方法：收集2020年10月至2021年8月期间于石河子大学医学院第一附属医院神经内科住院患者88例，采用酶联免疫法检测血清脂联素浓度。其中无脑梗死患者26例，脑梗死患者62例，在卒中发病后入院7天内根据蒙特利尔认知功能量表(Montreal Cognitive Assessment, MoCA)评分进行认知功能评估，MoCA总分 < 26分为伴有认知功能障碍。采用多因素Logistic回归分析确定血清脂联素水平和PSCI之间相关性。结果：1) 脑梗死组与健康对照组相比，高血压、吸烟、糖化血红蛋白、中性粒细胞计数之间差异有统计学意义(P < 0.05)；与脑梗死不伴有认知功能障碍组相比，脑梗死伴有认知功能障碍组年龄、性别、吸烟、饮酒之间差异有统计学意义(P < 0.05)。2) 脂联素是脑梗死有认知障碍患者的保护因素[OR = 0.938, 95% CI (0.890, 0.989), P = 0.017]。结论：脂联素水平低是PSCI的危险因素，可作为脑梗死后出现认知障碍的一项血液标志物。而适当饮酒相对缺血性脑卒中而言是保护因素。

Abstract: Objective: To investigate the serum adiponectin level and post-stroke cognitive impairment (PSCI) relevance. Methods: A total of 88 inpatients in the Department of Neurology, The First Affiliated Hospital of Shihezi University from October 2020 to August 2021 were collected. The serum adiponectin concentration was detected by Elisa. Among them, 26 patients without cerebral infarction and 62 patients with cerebral infarction were assessed for cognitive function according to the Montreal Cognitive Assessment (MoCA) scale score within 7 days after admission to hospital after the onset of stroke, and the MoCA score < 26 was classified as having cognitive dysfunction. Multivariate Logistic regression analysis was used to determine the correlation between serum adiponectin level and PSCI. Results: 1) Compared with the healthy control group, there were statistically significant differences in the biochemical indexes of hypertensive, smoking, hBA1c and neutrophil hormone in the cerebral infarction group (P < 0.05). Compared with the group without cognitive dysfunction, there were statistically significant differences in age, gender, smoking and alcohol consumption in the group with cognitive dysfunction (P < 0.05). 2) Adiponectin is a protective factor in patients with post-stroke cognitive impairment [P = 0.017, OR = 0.938, 95% CI (0.890, 0.989)]. Conclusion: Low adiponectin level is a risk factor for PSCI and can be used as a predictor of post-stroke cognitive impairment. Moderate alcohol consumption was a protective factor for ischemic stroke.