急性脑梗死出血转化生物学标志的预测价值及研究进展
Predictive Value and Research Progress of Biological Markers for the Transformation of Acute Cerebral Infarction Hemorrhage
DOI: 10.12677/ACM.2022.121054, PDF,    科研立项经费支持
作者: 牛 壮：青海大学研究生院，青海 西宁；胡全忠：青海省人民医院神经内科，青海 西宁
关键词: 脑梗死；出血转化；生物学标志；Occludin；FSTL1；Aβ；Cerebral Infarction； Hemorrhagic Transformation； Biological Markers； Occludin； FSTL1； Aβ
摘要: 急性脑梗死是造成不可逆脑损伤和严重残疾后遗症的常见原因，其中急性脑梗死后出血转化(HT)是急性缺血性脑卒中的常见并发症，是脑梗死后的一种特殊形式和自然预后的一个阶段。尤其是在经过血管内治疗后更易出现，HT出现后使病人症状迅速加重，并限制了下一步的治疗，使得病死率、致残率大大增加。所以早期预测HT有助于指导急性脑梗死的准确治疗，避免不良结局和不良预后，因此本文以讨论闭锁蛋白(Occludin, OCLN)、卵泡抑制素样蛋白1 (FSTL1)、β淀粉样蛋白(Aβ)等生物学标志物的研究进展来阐述其或可以作为预测出血转化的新生化指标，对HT的诊治提供帮助。
Abstract: Acute cerebral infarction is a common cause of irreversible brain injury and severe disability sequelae, of which hemorrhagic transformation (HT) after acute cerebral infarction is a common complication of acute ischemic stroke, a special form and a stage of natural prognosis after cerebral infarction. Especially after endovascular treatment, it is more likely to appear, and after the emergence of HT, the patient’s symptoms are rapidly aggravated, and the next step of treatment is restricted, so that the case fatality rate and disability rate are greatly increased. Therefore, early prediction of HT helps guide the accurate treatment of acute cerebral infarction and avoid adverse outcomes and adverse prognosis, so this paper discusses the research progress of biological markers such as locked protein (Occludin, OCLN), follicle inhibin-like protein 1 (FSTL1), β amyloid (Aβ) to illustrate that it may be used as a biochemical index to predict bleeding transformation and provide help in the diagnosis and treatment of HT.
文章引用：牛壮, 胡全忠. 急性脑梗死出血转化生物学标志的预测价值及研究进展[J]. 临床医学进展, 2022, 12(1): 358-364. https://doi.org/10.12677/ACM.2022.121054

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