基于“阳化气、阴成形”理论加味丁萸理中汤治疗上消化道溃疡的临床研究

Clinical Study on Modified Dingyu Lizhong Tang in the Treatment of Upper Gastrointestinal Ulcer Based on the Theory of “Yang Hua Qi and Yin Cheng Xing”

摘要: 目的：观察加味丁萸理中汤治疗上消化道溃疡的临床疗效及部分作用机制。方法：将72例上消化道溃疡患者随机平均分为治疗组和对照组，两组患者均予以西医常规治疗，治疗组患者给予口服中药加味丁萸理中汤，两组的疗程均为6周，观察两组患者治疗前后溃疡愈合率、Hp清除率，血清白介素8 (IL-8)、血清转化生长因子-α (TGF-α)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平变化情况。结果：两组患者血清IL-8、MDA水平降低，TGF-α、SOD表达量提高，但治疗组优于对照组(P < 0. 05)；两组患者治疗后溃疡病变程度均有一定程度改善，但治疗组患者溃疡愈合率及Hp清除率优于对照组，差异有统计学意义(P < 0.05)。结论：加味丁萸理中汤对上消化道溃疡患者具有明显的促粘膜修复作用，这可能与通过降低血清IL-8、MDA、升高血清TGF-α、SOD水平而发挥抗炎、抗氧化、根除Hp作用有关。

Abstract: Objective: The objective is to observe the clinical efficacy and partial mechanism of Dingyu Liz-hong Tang in the treatment of upper gastrointestinal ulcer. Methods: 72 patients with upper ga-strointestinal ulcer were selected they were randomly divided into treatment group and control group. Patients in both groups were treated with routine western medicine. Patients in the treatment group were treated with oral traditional Chinese medicine compound Dingyu Lizhong Tang. The course of treatment of both groups was 6 weeks. The ulcer healing rate, HP clearance rate, serum interleukin-8 (IL-8) and serum transforming growth factor-α (TGF-α) were observed before and after treatment, Changes of superoxide dismutase (SOD) and malondialdehyde (MDA) levels. Results: the levels of serum IL-8 and MDA decreased and TGF-α, The expression of SOD increased, but the treatment group was better than the control group (P < 0.05); The degree of ulcer lesion in the two groups was improved to a certain extent, but the ulcer healing rate and HP clearance rate in the treatment group were better than those in the control group (P < 0.05). Conclusion: Dingyu Lizhong Tang can significantly promote mucosal repair in patients with upper gastrointestinal ulcer, which may be related to reducing serum IL-8, MDA and increasing serum TGF-α. The level of SOD is related to its anti-inflammatory, antioxidant and HP eradication effects.