前列腺黏液肿瘤的临床特征及诊治分析

Clinical Features, Diagnosis and Treatment of Mucinous Tumors of Prostate

摘要: 前列腺癌是男性泌尿生殖系统最为常见的恶性肿瘤之一，而前列腺黏液肿瘤(mucinous tumors of prostate)是一类较为罕见的前列腺肿瘤亚型的集合。由于前列腺黏液肿瘤总体发病率低，其恶性程度及临床治疗策略存在一定争议并缺乏统一标准，阻碍了我们对其临床危险因素和预后的理解。本研究报道了我院7例前列腺黏液肿瘤患者的临床特征及病理学特点，首次详细报道了膀胱及消化道来源的前列腺黏液肿瘤，并分析了近20年相关文献，讨论这类罕见疾病的临床特点、诊断、病理免疫组化特征以及治疗和预后，旨在统一对于前列腺黏液肿瘤的认知及标准，明确治疗策略。同时更新了对前列腺黏液肿瘤的认识，为前列腺黏液肿瘤的诊疗提供了一定的数据。前列腺黏液肿瘤是一类较为罕见的前列腺肿瘤亚型的集合，病理学及免疫组化特征是诊断的关键。根治性手术切除仍是治疗首选，内分泌治疗尚缺乏更多研究，临床能否获益需要更多数据支持。

Abstract: Prostate cancer is one of the most common malignant tumors of the male genitourinary system, and mucinous tumor of prostate is a collection of relatively rare prostate tumor subtypes. Due to the low overall incidence of mucinous tumor of prostate, the degree of malignancy and clinical treatment strategies are controversial and lack unified standards, which hinder our understanding of its clinical risk factors and prognosis. This study reported the clinical and pathological characteristics of 7 patients with prostate mucinous tumor in our hospital, and reported the prostate mucinous tumor of bladder and digestive tract in detail for the first time. Related literatures in the last 20 years were analyzed to discuss the clinical characteristics, diagnosis, pathological immunohistochemical characteristics, treatment and prognosis of this rare disease. The aim is to unify the cognition and standard of prostate mucous tumor and clarify the treatment strategy. At the same time, the understanding of prostate mucinous tumor was updated, providing certain data for the diagnosis and treatment of prostate mucinous tumor. Mucinous tumor of prostate is a rare subtype of prostate tumor, and the pathological and immunohistochemical characteristics are the key to diagnosis. Radical surgical resection is still the first choice for treatment, while endocrine therapy is still lacking more studies, and the clinical benefits need more data support.