绝经后2型糖尿病肾病患者炎症因子与骨密度的相关性

Correlation between Inflammatory Factors and Bone Mineral Density in Postmenopausal Patients with Type 2 Diabetic Nephropathy

摘要: 目的：探讨绝经后2型糖尿病肾病患者血清炎症因子水平与骨密度的相关性。方法：选择50例2019年1月至2021年3月以来于我院就诊的绝经后2型糖尿病肾病患者，收集患者的一般临床资料和炎症因子等指标进行相关性分析。结果：绝经后2型糖尿病肾病患者骨密度与CRP、TNF-α、IL-6呈负相关(r值分别为−0.284、−0.174、−0.097，均P < 0.05)，而与IL-1β、IL-18无明显相关性。结论：本研究表明绝经后2型糖尿病肾病患者炎症因子水平与骨密度密切相关。

Abstract: Objective: To investigate the correlation between serum inflammatory factors and bone mineral density in postmenopausal patients with type 2 diabetic nephropathy. Methods: A total of 50 postmenopausal patients with type 2 diabetic nephropathy admitted to our hospital from January 2019 to March 2021 were selected, and their general clinical data and inflammatory factors and other indicators were collected for correlation analysis. Results: BMD was negatively correlated with CRP, TNF-α and IL-6 in postmenopausal patients with type 2 diabetic nephropathy (r = −0.284, −0.174, −0.097, all P < 0.05), but not with IL-1β and IL-18. Conclusions: This study indicates that the levels of inflammatory factors are closely related to bone mineral density in postmenopausal patients with type 2 diabetic nephropathy.