中药醋蛋液对小鼠II型糖尿病模型的影响

Effect of Traditional Chinese Medicine Vinegar Egg Solution on the Murine II Type Diabetes Model

摘要: 目的：糖尿病是世界难题，发病率逐年升高，目前尚无有效的根治方案。本研究主要是通过用中药偏方醋蛋液喂食糖尿病小鼠模型探讨其在降血糖和主要脏器保护方面的应用价值。方法：采用昆明(KM)品系小鼠80只，随机分成4组：1) 正常对照组；2) 糖尿病组：造模(高脂高糖 + 链脲佐菌素(STZ)诱导糖尿病模型)；3) 预防组：饮用醋蛋液 + 造模；4) 治疗组：造模后饮用醋蛋液。实验结束后，测量各组小鼠的空腹血糖情况并观察其预后。结果：各组小鼠的空腹血糖情况显示，对照组无高血糖小鼠(0/20, 0%)，糖尿病组出现7只高血糖小鼠(7/16, 43.75%)，预防组出现2只高血糖小鼠(2/13, 15.38%)，治疗组无高血糖小鼠(0/9, 0%)。各组小鼠的预后情况显示，治疗组小鼠的死亡率最高(13/22, 59.09%)，其次是预防组(7/20, 35%)，再次是糖尿病组(4/20, 20%)，正常对照组无死亡出现(0/20, 0%)。结论：本研究结果初步表明醋蛋液具有一定的预防高血糖和降血糖作用，但对于糖尿病小鼠可能具有毒副作用，因此基于以上的小鼠实验建议有糖尿病家族遗传史的人群可以预防性服用醋蛋液，糖尿病患者尤其是血糖浓度较高的患者谨慎使用醋蛋液。

Abstract: Objective: Diabetes is a world problem, the incidence is increasing year by year, and there is no effective radical cure plan. This study mainly discussed the application value of blood glucose re-duction and major organ protection by feeding diabetic mouse model with Chinese prescription vinegar egg solution. Methods: Eighty Kunming (KM) mice were randomly divided into 4 groups: 1) Normal control group; 2) Diabetes group: molding (high-fat and high-sugar + streptozotocin (STZ) induced diabetes model); 3) Prevention group: drinking vinegar egg liquid + molding; 4) Treatment group: drinking vinegar egg liquid after molding. After the experiment, the fasting blood glucose of each group of mice was measured and their prognosis was observed. Results: Fasting glucose in each group showed: no hyperglycemia mice (0/20, 0%), 7 hyperglycemia mice (7/16, 43.75%) in the diabetic group, 2 hyperglycemia mice (2/13, 15.38%) in the prevention group, and no hyperglycemia mice (0/9, 0%). Prognostic conditions in each group showed the highest mortality in the treated group (13/22, 59.09%), followed by prophylactic group (7/20, 35%), again diabetic group (4/20, 20%) and no death in normal control group (0/20, 0%). Con-clusions: The results of this study preliminarily show that vinegar egg liquid has certain preven-tive hyperglycemia and hypoglycemic effect, but it may have toxic side effects for diabetic mice, so based on the above mouse experiments suggest that people with family genetic history of diabetes can preventive take vinegar egg liquid, diabetic patients, especially patients with higher blood sugar concentration, carefully use vinegar egg liquid.