灯盏花素防治缺血性心脑血管疾病的分子机制研究进展
Molecular Mechanism of Scutellarin in the Prevention and Treatment of Ischemic Cardiovascular and Cerebrovascular Disease: A Review
摘要: 缺血性心脑血管疾病是由于高脂血症、血液黏稠、动脉粥样硬化、高血压等导致心脏、大脑及全身组织发生的缺血性心血管和脑血管疾病。缺血性心脑血管疾病遗留的器质性损伤和功能性障碍一直是困扰临床医生的难题。中医药在治疗缺血导致的细胞血管损伤疾病方面具有广泛的临床经验，其中灯盏花素是心脑血管疾病治疗中的常用药物，常与其他药物联合应用，在心脑血管疾病的治疗中发挥重要作用。灯盏花素具有舒张血管、降低血管张力、增加脑血流量、改善微循环和抗血小板聚集等多种药理作用，在临床已广泛应用于治疗各种心脑血管疾病，现综述灯盏花素防治缺血性心脑血管疾病的分子机制研究进展。
Abstract: Ischemic cardiovascular disease (ICVD) is an ischemic cardiovascular and cerebrovascular disease that occurs in the heart, brain, and systemic tissues as a result of hyperlipidemia, thick blood, atherosclerosis, and hypertension. The legacy of organic damage and functional impairment from ischemic cardio-cerebrovascular disease has been a difficult problem that plagues clinicians. Traditional Chinese medicine has extensive clinical experience in the treatment of diseases with cell vascular injury due to ischemia, among which scutellarin is a common drug used in the treatment of cardio-cerebrovascular diseases, often in combination with other drugs, and plays an important role in the treatment of cardio-cerebrovascular diseases. Scutellarin has many pharmacological effects, such as relaxing blood vessels, reducing vascular tone, increasing cerebral blood flow, improving microcirculation and antiplatelet aggregation, and has been widely used in the clinic for the treatment of various cardiovascular and cerebrovascular diseases. This review summarizes the molecular mechanisms of scutellarin in the prevention and treatment of ischemic cardiovascular and cerebrovascular diseases.
文章引用：张英平, 曲辅政. 灯盏花素防治缺血性心脑血管疾病的分子机制研究进展[J]. 临床医学进展, 2022, 12(1): 646-651. https://doi.org/10.12677/ACM.2022.121096

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