青年缺血性脑卒中病因及危险因素研究进展
Research Progress on Etiology and Risk Factors of Ischemic Stroke in Young People
DOI: 10.12677/ACM.2022.121103, PDF,   
作者: 齐祥东, 李小龙：延安大学附属医院，陕西 延安
关键词: 青年；缺血性脑卒中；危险因素；病因；Young Adults； Ischemic Stroke； Risk Factors； Etiology
摘要: 青年缺血性脑卒中指的是发生在18~45岁的卒中，在近几年发生率逐渐升高，主要是由于这一年龄组中传统血管危险因素的流行率上升，但也由于非法药物使用；尽管年轻卒中患者的生存率和功能结果均优于老年患者，但对预期寿命为几十年的患者来说，社会经济后果同样严重，给家庭和社会带来极大负担；相对于老年患者，青年卒中病因多样。因此，对其危险因素及发病机制的研究日益受到重视。本文对青年缺血性脑卒中进行综述，为制定有效防控措施，对青年脑卒中的预防提供参考。
Abstract: Ischemic stroke in young people refers to stroke that occurs between the ages of 18 and 45, and the incidence has gradually increased in recent years, mainly due to the increased prevalence of traditional vascular risk factors in this age group, and also due to the use of illegal drugs. Although the survival rate and functional outcome of young patients with stroke are better than those of elderly patients, the socio-economic consequences are also serious for patients with a life expectancy of several decades, which brings great burden to families and society. Compared with elderly patients, there are various causes of stroke in young people. Therefore, the research on its risk factors and pathogenesis has been paid more and more attention. This paper summarizes the ischemic stroke in young people, in order to formulate effective prevention and control measures and provide reference for the prevention of stroke in young people.
文章引用：齐祥东, 李小龙. 青年缺血性脑卒中病因及危险因素研究进展[J]. 临床医学进展, 2022, 12(1): 702-708. https://doi.org/10.12677/ACM.2022.121103

参考文献

[1] Katan, M. and Luft, A. (2018) Global Burden of Stroke. Seminars in Neurology, 38, 208-211. [Google Scholar] [CrossRef] [PubMed]
[2] MacGrory, B., Flood, S., Apostolidou, E., et al. (2019) Cryptogenic Stroke: Diagnostic Workup and Management. Current Treatment Options in Cardiovascular Medicine, 21, 77. [Google Scholar] [CrossRef] [PubMed]
[3] Marini, C., Russo, T., Felzani, G., et al. (2010) Incidence of Stroke in Young Adults: A Review. Stroke Research and Treatment, 2011, Article ID: 535672. [Google Scholar] [CrossRef] [PubMed]
[4] Wang, W., Jiang, B., Sun, H., et al. (2017) Prevalence, Incidence, and Mortality of Stroke in China: Results from a Nationwide Population-Based Survey of 480687 Adults. Circulation, 135, 759-771. [Google Scholar] [CrossRef] 
[5] Feigin, V. (2007) Stroke in Developing Countries: Can the Epidemic Be Stopped and Outcomes Improved? The Lancet Neurology, 6, 94-97. [Google Scholar] [CrossRef] 
[6] Simonetti, B., Mono, M., Huynh-Do, U., et al. (2016) Erratum to: Risk Factors, Aetiology and Outcome of Ischaemic Stroke in Young Adults: The Swiss Young Stroke Study (SYSS). Journal of Neurology, 263, 199-200. [Google Scholar] [CrossRef] [PubMed]
[7] George, M., Tong, X. and Bowman, B. (2017) Prevalence of Cardiovascular Risk Factors and Strokes in Younger Adults. JAMA Neurology, 74, 695-703. [Google Scholar] [CrossRef] [PubMed]
[8] Kissela, B., Khoury, J., Alwell, K., et al. (2012) Age at Stroke: Temporal Trends in Stroke Incidence in a Large, Biracial Population. Neurology, 79, 1781-1787. [Google Scholar] [CrossRef] 
[9] Adams, H., Bendixen, B., Kappelle, L., et al. (1993) Classification of Subtype of Acute Ischemic Stroke. Definitions for Use in a Multicenter Clinical Trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke, 24, 35-41. [Google Scholar] [CrossRef] 
[10] Cerrato, P., Grasso, M., Imperiale, D., et al. (2004) Stroke in Young Patients: Etiopathogenesis and Risk Factors in Different Age Classes. Cerebrovascular Diseases, 18, 154-159. [Google Scholar] [CrossRef] [PubMed]
[11] Li, F., Yang, L., Yang, R., et al. (2017) Ischemic Stroke in Young Adults of Northern China: Characteristics and Risk Factors for Recurrence. European Neurology, 77, 115-122. [Google Scholar] [CrossRef] [PubMed]
[12] 宋晓微, 薛素芳, 李潇颖, 等. 青年缺血性卒中患者脑动脉狭窄的分布特点及病因分析[J]. 中国脑血管病杂志, 2014, 11(3): 142-147.
[13] Griffiths, D. and Sturm, J. (2011) Epidemiology and Etiology of Young Stroke. Stroke Research and Treatment, 2011, Article ID: 209370. [Google Scholar] [CrossRef] [PubMed]
[14] 陈红兵, 洪华, 刘刚, 等. 青年缺血性卒中的危险因素、诊断评估、病因和治疗: 一项前瞻性单中心登记研究[J]. 国际脑血管病杂志, 2015(9): 669-676.
[15] 宋波, 王蕾, 高励, 等. 青年缺血性卒中的危险因素和病因学[J]. 国际脑血管病杂志, 2018, 26(3): 178-183.
[16] Ji, R., Schwamm, L., Pervez, M., et al. (2013) Ischemic Stroke and Transient Ischemic Attack in Young Adults: Risk Factors, Diagnostic Yield, Neuroimaging, and Thrombolysis. JAMA Neurology, 70, 51-57. [Google Scholar] [CrossRef] [PubMed]
[17] Varona, J., Guerra, J., Bermejo, F., et al. (2007) Causes of Ischemic Stroke in Young Adults, and Evolution of the Etiological Diagnosis over the Long Term. European Neurology, 57, 212-218. [Google Scholar] [CrossRef] [PubMed]
[18] Aigner, A., Grittner, U., Rolfs, A., et al. (2017) Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults. Stroke, 48, 1744-1751. [Google Scholar] [CrossRef] 
[19] Smajlović, D. (2015) Strokes in Young Adults: Epidemiology and Prevention. Vascular Health and Risk Management, 11, 157-164. [Google Scholar] [CrossRef] 
[20] Spence, J. (2018) Cardioembolic Stroke: Everything Has Changed. Stroke and Vascular Neurology, 3, 76-83. [Google Scholar] [CrossRef] [PubMed]
[21] Lamy, C., Giannesini, C., Zuber, M., et al. (2002) Clinical and Imaging Findings in Cryptogenic Stroke Patients with and without Patent Foramen Ovale: The PFO-ASA Study. Atrial Septal Aneurysm. Stroke, 33, 706-711. [Google Scholar] [CrossRef] [PubMed]
[22] Nouh, A., Hussain, M., Mehta, T., et al. (2016) Embolic Strokes of Unknown Source and Cryptogenic Stroke: Implications in Clinical Practice. Frontiers in Neurology, 7, Article No. 37. [Google Scholar] [CrossRef] [PubMed]
[23] Thaler, D., Ruthazer, R., Di Angelantonio, E., et al. (2013) Neuroimaging Findings in Cryptogenic Stroke Patients with and without Patent Foramen Ovale. Stroke, 44, 675-680. [Google Scholar] [CrossRef] 
[24] Alsheikh-Ali, A., Thaler, D. and Kent, D. (2009) Patent Foramen Ovale in Cryptogenic Stroke: Incidental or Pathogenic? Stroke, 40, 2349-2355. [Google Scholar] [CrossRef] 
[25] Van Den Boom, R., Lesnick Oberstein, S., Van Den Berg-Huysmans, A., et al. (2006) Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy: Structural MR Imaging Changes and Apolipoprotein E Genotype. AJNR. American Journal of Neuroradiology, 27, 359-362.
[26] Debette, S. and Leys, D. (2009) Cervical-Artery Dissections: Predisposing Factors, Diagnosis, and Outcome. The Lancet Neurology, 8, 668-678. [Google Scholar] [CrossRef] 
[27] Blum, C. and Yaghi, S. (2015) Cervical Artery Dissection: A Review of the Epidemiology, Pathophysiology, Treatment, and Outcome. Archives of Neuroscience, 2, e26670. [Google Scholar] [CrossRef] [PubMed]
[28] Rubinstein, S., Peerdeman, S., Van Tulder, M., et al. (2005) A Systematic Review of the Risk Factors for Cervical Artery Dissection. Stroke, 36, 1575-1580. [Google Scholar] [CrossRef] 
[29] Hakimi, R. and Sivakumar, S. (2019) Imaging of Carotid Dissection. Current Pain and Headache Reports, 23, 2. [Google Scholar] [CrossRef] [PubMed]
[30] Abdel Razek, A., Alvarez, H., Bagg, S., et al. (2014) Imaging Spectrum of CNS Vasculitis. Radiographics, 34, 873-894. [Google Scholar] [CrossRef] [PubMed]
[31] Birnbaum, J. and Hellmann, D. (2009) Primary Angiitis of the Central Nervous System. Archives of Neurology, 66, 704-709. [Google Scholar] [CrossRef] [PubMed]
[32] Oyoo, O. and Espinoza, L. (2005) Infection-Related Vasculitis. Current Rheumatology Reports, 7, 281-287. [Google Scholar] [CrossRef] [PubMed]
[33] De Boysson, H., Zuber, M., Naggara, O., et al. (2014) Primary Angiitis of the Central Nervous System: Description of the First Fifty-Two Adults Enrolled in the French Cohort of Patients with Primary Vasculitis of the Central Nervous System. Arthritis & Rheumatology (Hoboken, N.J.), 66, 1315-1326. [Google Scholar] [CrossRef] [PubMed]
[34] Jillella, D. and Wisco, D. (2019) Infectious Causes of Stroke. Current Opinion in Infectious Diseases, 32, 285-292. [Google Scholar] [CrossRef] 
[35] Mugikura, S., Takahashi, S., Higano, S., et al. (1999) The Relationship between Cerebral Infarction and Angiographic Characteristics in Childhood Moyamoya Disease. AJNR. American Journal of Neuroradiology, 20, 336-343.
[36] 徐斌, 顾宇翔. 烟雾病和烟雾综合征诊断与治疗中国专家共识(2017) [J]. 中华神经外科杂志, 2017, 33(6): 541-547.
[37] Hamedani, A., Cole, J., Mitchell, B., et al. (2010) Meta-Analysis of Factor V Leiden and Ischemic Stroke in Young Adults: The Importance of Case Ascertainment. Stroke, 41, 1599-1603. [Google Scholar] [CrossRef] 
[38] Raffini, L. and Thornburg, C. (2009) Testing Children for Inherited Thrombophilia: More Questions than Answers. British Journal of Haematology, 147, 277-288. [Google Scholar] [CrossRef] [PubMed]
[39] Furie, K., Kasner, S., Adams, R., et al. (2011) Guidelines for the Prevention of Stroke in Patients with Stroke or Transient Ischemic Attack: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke, 42, 227-276. [Google Scholar] [CrossRef] 
[40] Adams, H. and Biller, J. (2015) Classification of Subtypes of Ischemic Stroke: History of the Trial of Org 10172 in Acute Stroke Treatment Classification. Stroke, 46, e114-e117. [Google Scholar] [CrossRef] 
[41] Miller, T., Shivashankar, R., Mossa-Basha, M., et al. (2015) Reversible Cerebral Vasoconstriction Syndrome, Part 1: Epidemiology, Pathogenesis, and Clinical Course. AJNR. American Journal of Neuroradiology, 36, 1392-1399. [Google Scholar] [CrossRef] 
[42] Calabrese, L., Dodick, D., Schwedt, T., et al. (2007) Narrative Review: Reversible Cerebral Vasoconstriction Syndromes. Annals of Internal Medicine, 146, 34-44. [Google Scholar] [CrossRef] [PubMed]
[43] Mandell, D., Mossa-Basha, M., Qiao, Y., et al. (2017) Intracranial Vessel Wall MRI: Principles and Expert Consensus Recommendations of the American Society of Neuroradiology. AJNR. American Journal of Neuroradiology, 38, 218-229. [Google Scholar] [CrossRef] 
[44] Lindenholz, A., Van Der Kolk, A., Zwanenburg, J., et al. (2018) The Use and Pitfalls of Intracranial Vessel Wall Imaging: How We Do It. Radiology, 286, 12-28. [Google Scholar] [CrossRef] [PubMed]
[45] Chabriat, H., Joutel, A., Dichgans, M., et al. (2009) Cadasil. The Lancet Neurology, 8, 643-653. [Google Scholar] [CrossRef] 
[46] Coutinho, J.M., et al. (2017) Carotid Artery Web and Ischemic Stroke: A Case-Control Study. Neurology, 88, 65-69. [Google Scholar] [CrossRef] 
[47] Venkatesan, E.P., Dilip, S., et al. (2017) MR Imaging of Carotid Webs. Neuroradiology, 59, 361-365. [Google Scholar] [CrossRef] [PubMed]
[48] Phair, J., Trestman, E., Yean, C., et al. (2017) Endarterectomy for a Symptomatic Carotid Web. Vascular, 25, 553-556. [Google Scholar] [CrossRef] [PubMed]
[49] Fonseca, A. and Ferro, J. (2013) Drug Abuse and Stroke. Current Neurology and Neuroscience Reports, 13, 325. [Google Scholar] [CrossRef] [PubMed]
[50] George, M.G., Tong, X. and Bowman, B.A. (2017) Prevalence of Cardiovascular Risk Factors and Strokes in Younger Adults. JAMA Neurology, 74, 695-703. [Google Scholar] [CrossRef] [PubMed]
[51] 王力, 何晓芬, 王力锋, 等. 青年脑梗死患者危险因素及病因学分型分析[J]. 中国医药, 2019, 14(8): 1173-1176.
[52] Schürks, M., Buring, J. and Kurth, T. (2010) Migraine, Migraine Features, and Cardiovascular Disease. Headache, 50, 1031-1040. [Google Scholar] [CrossRef] [PubMed]
[53] Giroud, M., Delpont, B., Daubail, B., et al. (2017) Temporal Trends in Sex Differences with Regard to Stroke Incidence: The Dijon Stroke Registry (1987-2012). Stroke, 48, 846-849. [Google Scholar] [CrossRef] 
[54] Kanekar, S. and Bennett, S. (2016) Imaging of Neurologic Conditions in Pregnant Patients. Radiographics, 36, 2102-2122. [Google Scholar] [CrossRef] [PubMed]
[55] Swartz, R., Cayley, M., Foley, N., et al. (2017) The Incidence of Pregnancy-Related Stroke: A Systematic Review and Meta-Analysis. International Journal of Stroke, 12, 687-697. [Google Scholar] [CrossRef] [PubMed]

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