microRNA-PUMA信号通路在非肿瘤性疾病中的研究进展
Research Progress in the Regulation of Puma Expression by microRNA in Non-Neoplastic Diseases
DOI: 10.12677/ACM.2022.121104, PDF,    科研立项经费支持
作者: 田王钊：青海大学，青海 西宁；芦永福, 王学红：青海大学附属医院，青海 西宁
关键词: p53正向细胞凋亡调控因子；microRNA；非肿瘤性疾病；p53 Up-Regulated Modulator of Apoptosis； microRNA； Non-Neoplastic Diseases
摘要: p53正向细胞凋亡调控因子(p53 up-regulated modulator of apoptosis, PUMA)在许多疾病的发生发展中发挥着至关重要的作用，其调控机制主要为转录水平的调控(p53依赖/非依赖途径)及翻译后磷酸化调控机制，相关microRNA-PUMA信号通路的发现，不仅为肿瘤性疾病的治疗提供了新依据，也为许多非肿瘤性疾病的治疗提供了新思路，如老年性急性心肌梗死、心脏瓣膜病、神经元退行性变、血脑屏障等疾病近年来有了新的突破，甚至有望成为疾病新的预测分子。本文主要从microRNA-PUMA相关通路的发现就近年来在非肿瘤性疾病中的研究作一综述。
Abstract: p53 up-regulated modulator of apoptosis (PUMA) plays an important role in the development of many diseases. Its regulatory mechanisms include transcriptional regulation (p53-dependent/ non-dependent pathway) and post-translational phosphorylation. The discovery of related microRNA-PUMa signaling pathway not only provides a new basis for the treatment of neoplastic diseases, but also provides a new idea for the treatment of many non-neoplastic diseases: for example, senile acute myocardial infarction, heart valvular disease, neuronal degeneration, blood-brain barrier and other diseases have made new breakthroughs in recent years, and are even expected to become new predictive molecules of diseases. In this paper, the findings of microRNA-PUMA related pathways in non-neoplastic diseases in recent years are reviewed.
文章引用：田王钊, 芦永福, 王学红. microRNA-PUMA信号通路在非肿瘤性疾病中的研究进展[J]. 临床医学进展, 2022, 12(1): 709-715. https://doi.org/10.12677/ACM.2022.121104

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