122例手足口病患儿血常规、心肌酶谱及血糖动态检测及临床意义

The Clinical Significance of Blood Routine Tests, Myocardial Enzyme Spectrum and Plasma Glucose in the 122 Children with Hand Foot and Mouth Disease (HFMD)

摘要: 目的：探讨手足口病患儿血常规、心肌酶谱和血糖动态变化特点及临床意义。方法：2019年1月至2020年12月我科住院的122例手足口病患儿作为观察组，100例同期健康体检儿童作为对照组，回顾性分析、比较观察组治疗前、后的血常规、心肌酶谱和空腹血糖水平变化及与对照组的差异，同时分析其异常率。结果：观察组患儿治疗前各项指标水平(除LYM外)及异常率(除AST、CK外)显著高于对照组(P < 0.05)；观察组患儿治疗后各项指标水平(除CK外)及异常率(除AST、CK外)显著低于治疗前(P < 0.05)；观察组患儿治疗后LDH、HBDH、CKMB、WBC、LYM、MONO水平显著高于对照组(P < 0.05)，各指标异常率比较差异均无统计学意义(P > 0.05)。结论：动态检测血常规、心肌酶谱和血糖变化，对监测病情及判断预后有一定的临床意义。临床上应及时有效地给予营养心肌等治疗措施，积极防治并发症，有助于取得更好的疗效。

Abstract: Objective: To explore the dynamic changes of blood routine, myocardial enzyme spectrum and plasma glucose and their clinical significance in children with hand foot and mouth disease (HFMD). Methods: 122 children with HFMD admitted to the hospital from January 2019 to December 2020 were enrolled as observation group and 100 healthy children as control group in the same period. Retrospectively analyze the changes of blood routine, myocardial enzyme spectrum and plasma glucose levels before and after treatment in children with HFMD, and compare the changes and differences with the control group. The abnormal rates of the laboratory measurements were also analyzed. Results: The levels of the indicators (except LYM) and their abnormal rates (except AST, CK) in the observation group before treatment were higher than those in the control group (P < 0.05). The levels of the indicators (except CK) and their abnormal rates (except AST, CK) in the observation group declined after treatment compared to those before (P < 0.05). The levels of LDH and HBDH, CKMB, WBC, LYM, MONO in the observation group were significantly higher after treatment than those in the control group (P < 0.05). There were no significant differences of the abnormal rates in all indicators between the observation group after treatment and the control group (P > 0.05). Conclusion: Dynamic detection of blood routine, myocardial enzymes and plasma glucose levels play a guiding role in monitoring the development and outcome of the disease in the clinic. In addition, timely and effective myocardial nutrition therapy should be performed to prevent complications, which helps to better outcomes.