糖代谢异常患者上尿路结石的相关危险因素的研究

Related Risk Factor Analysis for Upper Urinary Tract Stones in Patients with Abnormal Glucose Metabolism

摘要: 目的：探讨糖代谢异常与上尿路结石的危险因素并分析。方法：选取2019年1月至2019年12月山东省青岛市市立医院(本部院区及东院区)收治的共264例泌尿系结石患者为研究对象，将患者分为糖代谢异常合并尿路结石组和单纯尿路结石组，比较两组年龄、性别等一般资料及血液、尿液的部分相关实验室指标的差异，采用单因素和多因素Logistic回归分析糖代谢异常状态与泌尿系结石的独立危险因素。结果：糖代谢异常合并尿路结石组相比单纯尿路结石组，在单因素差异分析中，两组患者的年龄、性别、肌酐、TC、LDL、血钙、血磷等资料相比较差异无统计学意义(P > 0.05)。两组患者的尿PH、尿比重、空腹血糖、尿素氮、尿酸、TG及HDL比较有统计学差异(P < 0.05)。经多因素Logistic回归分析后，结果提示尿液pH及空腹血糖为泌尿系结石的独立危险因素(P < 0.05)。结论：血糖升高和尿pH为尿路结石形成的独立危险因素。

Abstract: Objective: To explore and analyze the related factors of upper urinary tract stones in patients with abnormal glucose metabolism. Methods: Retrospective analysis of clinical data of patients with upper urinary calculi diagnosed in the Qingdao Municipal Hospital (the main campus and the east campus) from January 2019 to December 2019. The patients were divided into abnormal glucose metabolism combined with urinary calculi group and simple urinary calculi group. Compare the differences in general information such as age and gender and some related laboratory indicators of blood and urine between the two groups. Univariate analysis and multivariate Logistic regression were used to analyze the independent risk factors of abnormal glucose metabolism combined with urinary calculi group and simple urinary calculi group. Results: The clinical data of the two groups were compared and analyzed. There were no significant differences in age, gender, Scr, TC, LDL, blood calcium, blood phosphorus between the two groups (P > 0. 05), however significant differences were noticed in the urine PH, urine specific gravity, fasting blood glucose, BUN, blood uric acid, TG and HDL (P < 0. 05). Multivariate logistic regression analysis revealed that abnormal glucose metabolism and urine pH were independent factors affecting the formation of stones (P <0. 05). Conclusion: Abnormal glucose metabolism and urine pH are independent factors affecting the formation of stones.