miRNA与动脉粥样硬化相关性研究进展
Research Progress of Correlation between miRNA and Atherosclerosis
DOI: 10.12677/ACM.2022.122126, PDF,    科研立项经费支持
作者: 杨 艳, 陈 鹏:昆明医科大学药学院暨云南省天然药物药理重点实验室,云南 昆明
关键词: 微小核糖核酸动脉粥样硬化内皮细胞平滑肌细胞巨噬细胞miRNA Atherosclerosis Endothelial Cells Smooth Muscle Cells Macrophages
摘要: 微小核糖核酸(miRNA, MicroRNA)是一类非编码单链RNA分子,越来越多的研究证据表明miRNA能够影响动脉粥样硬化(atherosclerosis, AS)的发生发展,并为AS的诊断及治疗提供了靶点。AS发生发展主要和内皮细胞、平滑肌细胞、巨噬细胞密切相关。本文就miRNA通过作用于平滑肌细胞、巨噬细胞、内皮细胞影响AS的相关研究进展进行综述。
Abstract: miRNA is a kind of non-coding single stranded RNA molecules. In recent years, more and more studies have shown that miRNA can affect the occurrence and development of atherosclerosis, and supply a target for the diagnosis and treatment of AS. The development of AS is closely related to endothelial cells, smooth muscle cells and macrophages. This paper reviews the research progress on the impacts of miRNA on AS by acting on smooth muscle cells, macrophages and endothelial cells.
文章引用:杨艳, 陈鹏. miRNA与动脉粥样硬化相关性研究进展[J]. 临床医学进展, 2022, 12(2): 877-881. https://doi.org/10.12677/ACM.2022.122126

参考文献

[1] Noels, H., Weber, C. and Koenen, R.R. (2019) Chemokines as Therapeutic Targets in Cardiovascular Disease. ArteriosclerThromb Vascular Biology, 39, 583-592. [Google Scholar] [CrossRef
[2] 马文君, 马涵萍, 王运红, 等. 《2021年中国心血管病医疗质量报告》概要[J]. 中国循环杂志, 2021, 36(11): 1041-1064.
[3] Tao, J., Xia, L., Cai, Z., et al. (2021) Interaction between microRNA and DNA Methylation in Atherosclerosis. DNA and Cell Biology, 40, 101-115. [Google Scholar] [CrossRef] [PubMed]
[4] Lee, H., Han, S., Kwon, C.S., et al. (2016) Biogenesis and Regulation of the let-7 miRNAs and Their Functional Implications. Protein Cell, 7, 100-113. [Google Scholar] [CrossRef] [PubMed]
[5] Mohr, A.M. and Mott, J.L. (2015) Overview of microRNA Biology. Seminars in Liver Disease, 35, 3-11. [Google Scholar] [CrossRef] [PubMed]
[6] Schober, A., Nazarijahantigh, M. and Weber, C. (2015) MiRNA-Mediated Mechanisms of the Cellular Stress Response in Atherosclerosis. Nature Reviews Cardiology, 12, 361-374. [Google Scholar] [CrossRef] [PubMed]
[7] Loyer, X., Potteaux, S., Vion, A.C., et al. (2012) Inhibition of miRNA-92a Prevents Endothelial Dysfunction and Atherosclerosis in Mice. Circulation Research, 114, 434-443. [Google Scholar] [CrossRef
[8] Schober, A., Schober, A., Nazarijahantigh, M., et al. (2015) MiRNA-126-5p Promotes Endothelial Proliferation and Limits Atherosclerosis by Suppressing Dlk1. Nature Medicine, 20, 368-376. [Google Scholar] [CrossRef] [PubMed]
[9] Ohta, M., Kihara, T., Toriuchi, K., et al. (2020) IL-6 Promotes Cell Adhesion in Human Endothelial Cells via microRNA-126-3p Suppression. Experimental Cell Research, 393, Article ID: 112094. [Google Scholar] [CrossRef] [PubMed]
[10] Su, Y., Yuan, J., Zhang, F., et al. (2019) MicroRNA-181a-5p and microRNA-181a-3p Cooperatively Restrict Vascular Inflammation and Atherosclerosis. Cell Death & Disease, 10, 365. [Google Scholar] [CrossRef] [PubMed]
[11] Hergenreider, E., Heydt, S., Treguer, K., et al. (2012) Atheroprotective Communication between Endothelial Cells and Smooth Muscle Cells through miRNAs. Nature Cell Biology, 14, 249. [Google Scholar] [CrossRef] [PubMed]
[12] Cordes, K.R., Sheehy, N.T., White, M.P., et al. (2009) miR-145 and miR-143 Regulate Smooth Muscle Cell Fate and Plasticity. Nature, 460, 705-710. [Google Scholar] [CrossRef] [PubMed]
[13] You, L., Chen, H., Xu, L., et al. (2020) Overexpression of miR29a-3-p Suppresses Proliferation, Migration, and Invasion of Vascular Smooth Muscle Cells in Atherosclerosis via Targeting TNFRSF1A. BioMed Research International, 2020, Article ID: 9627974. [Google Scholar] [CrossRef] [PubMed]
[14] Alshanwani, A.R., Riches-Suman, K., O’Regan, D.J., et al. (2018) MicroRNA-21 Drives the Switch to a Synthetic Phenotype in Human Saphenous Vein Smooth Muscle Cells. IUBMB Life, 70, 649-657. [Google Scholar] [CrossRef] [PubMed]
[15] Sun, D., Xiang, G., Wang, J., et al. (2020) miRNA146b-5p Protects against Atherosclerosis by Inhibiting Vascular Smooth Muscle Cell Proliferation and Migration. Epigenomics, 12, 2189-2204. [Google Scholar] [CrossRef] [PubMed]
[16] Wang, W., Ma, F. and Zhang, H. (2020) MicroRNA-374 Is a Potential Diagnostic Biomarker for Atherosclerosis and Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells. Cardiovascular Diagnosis and Therapy, 10, 687-694. [Google Scholar] [CrossRef] [PubMed]
[17] Shan, R., Liu, N., Yan, Y., et al. (2021) Apoptosis, Autophagy and Atherosclerosis: Relationships and the Role of HSP27. Pharmacological Research, 166, Article ID: 105169. [Google Scholar] [CrossRef] [PubMed]
[18] Ouimet, M., Ediriweera, H.N., Gundra, U.M., et al. (2015) MicroRNA-33-Dependent Regulation of Macrophage Metabolism Directs Immune Cell Polarization in Atherosclerosis. Clinical Investigation, 125, 4334-4348. [Google Scholar] [CrossRef
[19] Cai, X., Yin, Y., Li, N., et al. (2012) Re-Polarization of Tumor-Associated Macrophages to Pro-Inflammatory M1 Macrophages by microRNA-155. Molecular and Cellular Biology, 4, 341-343. [Google Scholar] [CrossRef] [PubMed]
[20] Wei, Y., Nazari-Jahantigh, M., Chan, L., et al. (2013) The microRNA-342-5p Fosters Inflammatory Macrophage Activation through an Akt1- and microRNA-155-Dependent Pathway during Atherosclerosis. Circulation, 127, 1609-1619. [Google Scholar] [CrossRef
[21] Li, K., Ching, D., Luk, F.S., et al. (2015) Apolipoprotein E Enhances microRNA-146a in Monocytes and Macrophages to Suppress Nuclear Factor-ΚB-Driven Inflammation and Atherosclerosis. Circulation Research, 114, Article ID: 305844. [Google Scholar] [CrossRef
[22] Karshovska, E., Wei, Y., Subramanian, P., et al. (2020) HIF-1α (Hypoxiainducible Factor-1α) Promotes Macrophage Necroptosis by Regulating miR-210 and miR-383. Arteriosclerosis, Thrombosis, and Vascular Biology, 40, 583-596. [Google Scholar] [CrossRef
[23] Pereira-da-Silva, T., Napoleão, P., Costa, M.C., et al. (2021) Circulating miRNAs Are Associated with the Systemic Extent of Atherosclerosis: Novel Observations for miR27b and miR146. Diagnostics (Basel), 11, 318. [Google Scholar] [CrossRef] [PubMed]
[24] Yebenes, V.G., Briones, A.M., Martos-Folgado, I., et al. (2020) Agingassociated miR217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology, 40, 2408-2424. [Google Scholar] [CrossRef
[25] Liang, X., Wang, L., Wang, M., et al. (2020) MicroRNA-124 Inhibits Macrophage Cell Apoptosis via Targeting p38/MAPK Signaling Pathway in Atherosclerosis Development. Aging (Albany NY), 12, 13005-13022. [Google Scholar] [CrossRef] [PubMed]
[26] Qiao, Y., Wang, C., Kou, J., et al. (2020) Micro RNA-23a Suppresses the Apoptosis of Inflammatory Macrophages and Foam Cells in Atherogenesis by Targeting HSP90. Gene, 729, Article ID: 144319. [Google Scholar] [CrossRef] [PubMed]