1例耐药侵蚀性葡萄胎病例汇报

A Case Report of Drug Resistant Invasive Mole

摘要: 妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia, GTN)是一组与妊娠相关、起源于胎盘滋养细胞的恶性肿瘤，其中包含以下几种：侵袭性葡萄胎(invasive mole, IM)、绒毛膜癌(choriocarcinoma, CCA)、上皮性滋养细胞肿瘤(epithelial trophoblastic tumor, ETT)和胎盘部位滋养细胞肿瘤(placental site trophoblastic tumor, PSTT)。随着有效化疗药物的临床应用，GTN临床治愈率达到了90%以上，但仍有10%对化疗药物不敏感的耐药患者，但目前国内外仍缺乏对耐药性GTN的诊断与治疗标准。本文对我院收治的1例低危耐药型侵蚀性葡萄胎病例进行临床分析，就其诊断、治疗、随访及转归情况，结合相关文献进行讨论，以总结经验，指导临床工作。

Abstract: Gestational trophoblastic tumor (GTN) is a group of malignant tumors related to pregnancy and originated from placental trophoblasts, including invasive mole (IM), choriocarcinoma (CCA), epithelial trophoblastic tumor (ETT) and placental site trophoblastic tumor (PSTT). With the clinical application of effective chemotherapeutic drugs, the clinical cure rate of GTN has reached more than 90%, but there are still 10% drug-resistant patients who are not sensitive to chemotherapeutic drugs. However, there is still a lack of diagnostic and treatment standards for drug-resistant GTN at home and abroad. This paper makes a clinical analysis of a case of low-risk drug-resistant invasive mole treated in our hospital, and discusses its diagnosis, treatment, follow-up and prognosis in combination with relevant literature, so as to summarize experience and guide clinical work.