D-二聚体可反映近期皮层下小梗死患者脑小血管病总磁共振负担的严重程度
D-Dimer Reflects the Severity of Total MRI Burden of Cerebral Small Vessel Disease in Patients with Recent Small Subcortical Infarct
摘要: 背景：大量研究表明D-二聚体参与脑梗死的病理过程，我们此次研究目的是探索D-二聚体与脑小血管病的关系。方法：我们纳入了294名近期皮层下小梗死患者，收集了新发小梗死患者的临床资料，分析了纳入患者的颅脑磁共振影像，并且探索了D-二聚体与脑小血管病总磁共振负担及其各种影像学分型的相关性。结果：更高的D-二聚体反映了更严重的脑小血管病总磁共振负担，在脑小血管病总磁共振负担的影像学特征中，D-二聚体主要与脑白质高信号以及血管周围间隙有关，与微出血及腔隙无关。讨论：D-二聚体可反映白质高信号及血管周围间隙的严重程度，进而反映了脑小血管病总磁共振负担的大小。
Abstract: Background: A large number of studies have shown that D-dimer is involved in the pathological process of cerebral infarction. The purpose of our study is to explore the relationship between D-dimer and cerebral small vessel disease. Methods: 294 patients with recent small subcortical infarcts were included in our study. We collected clinical data and brain magnetic resonance images of patients, and explored the relationship between D-dimer and total MRI burden of cerebral small vessel disease with its imaging characters. Results: D-dimer showed a positive correlation with total MRI burden of cerebral small vessel disease. Among the imaging characters of total MRI burden of cerebral small vessel disease, D-dimer is mainly associated with white matter hyperintensity and enlarged perivascular space, not related to microbleeds and lacunae. Discussion: D-dimer reflects the severity of white matter hyperintensity and perivascular space, which in turn reflects the total MRI burden of cerebral small vessel disease.
文章引用：郝中楠, 邱蕊, 曲红梅. D-二聚体可反映近期皮层下小梗死患者脑小血管病总磁共振负担的严重程度[J]. 临床医学进展, 2022, 12(2): 959-968. https://doi.org/10.12677/ACM.2022.122140

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