血脂代谢与乳腺癌全程的相关性研究进展
Research Progress on the Correlation between Blood Lipid Metabolism and the Whole Process of Breast Cancer
摘要: 学者们普遍认为乳腺癌是多个因素共同参与的结果,即基因–膳食–环境等多因素,其中可能发挥重要作用的是脂质代谢水平及其调控。随着生活水平的改善,血脂升高在正常人群中的比例明显上升,血脂与乳腺癌的关系也受到越来越多的重视,多项研究表明血脂与乳腺癌的发生密切相关。近年来血脂代谢异常与乳腺癌的发生、发展、病理类型及预后之间的相关性被越来越多的学者关注。乳腺癌的治疗过程中常伴随着血脂和脂蛋白水平的改变,这些改变与乳腺癌的发展和预后密切相关。因此本文就血脂代谢异常与乳腺癌全程的相关性研究进展进行综述,指导乳腺癌患者的合理的饮食,保持健康的生活方式。
Abstract: Scholars generally believe that breast cancer is the result of the joint participation of multiple factors, namely, gene-diet-environment and other factors. Among them, lipid metabolism and its regulation may play an important role. With the improvement of living standards, the proportion of elevated blood lipids in the normal population has increased significantly, and the relationship between blood lipids and breast cancer has received more and more attention. Many studies have shown that blood lipids are closely related to the occurrence of breast cancer. In recent years, the correlation between abnormal lipid metabolism and the occurrence, development, pathological type and prognosis of breast cancer has been paid more and more attention by scholars. The treatment of breast cancer is often accompanied by changes in blood lipid and lipoprotein levels, which are closely related to the development and prognosis of breast cancer. Therefore, this article reviews the research progress on the correlation between abnormal blood lipid metabolism and breast cancer, and guides breast cancer patients to have a reasonable diet and maintain a healthy lifestyle.
文章引用:屈万丽, 张生军. 血脂代谢与乳腺癌全程的相关性研究进展[J]. 临床医学进展, 2022, 12(2): 991-996. https://doi.org/10.12677/ACM.2022.122144

参考文献

[1] 刘宗超, 李哲轩, 张阳, 等. 2020全球癌症统计报告解读[J]. 肿瘤综合治疗电子杂志, 2021, 7(2): 1-14.
[2] 曹毛毛, 陈万青. GLOBOCAN 2020全球癌症统计数据解读[J]. 中国医学前沿杂志(电子版), 2021, 13(3): 63-69.
[3] 荣国华. GRIM-19及其靶基因STAT-3在乳腺癌组织中的表达及意义[D]: [硕士学位论文]. 济南: 山东大学, 2011.
[4] 郭茹. 快速康复理念在肛瘘患者术后护理中的应用分析[J]. 饮食保健, 2020, 7(32): 228-229.
[5] 郑芳, 赵金波. 血脂水平与乳腺癌关系的研究进展[J]. 医学综述, 2015, 21(21): 3913-3916.
[6] 全吉钟, 冯燕, 王云峰, 等. 血脂水平与乳腺癌发生的临床关系研究[J]. 中国实验诊断学, 2014, 18(1): 109-110.
[7] 张艳利. 血脂与脂蛋白水平与乳腺癌发生及其临床病理学特征的相关性分析[D]: [硕士学位论文]. 重庆: 重庆医科大学, 2018.
[8] 潘持国, 齐清燕, 孙毅, 等. 血脂指标与血清肿瘤标志物联合检测在乳腺癌诊断中的应用价值[J]. 实用检验医师杂志, 2021, 13(1): 13-15.
[9] 邓赢芳, 王淼舟. 血脂水平与乳腺癌关系的研究现状和进展[J]. 临床医药文献电子杂志, 2019, 6(5): 186.
[10] Hiona, A., Lee, A.S., Nagendran, J., et al. (2010) Pretreatment with Angiotensin-Converting Enzyme Inhibitor Improves Doxorubicin-Induced Cardiomyopathy via Preservation of Mitochondrial Function. The Journal of Thoracic and Cardiovascular Surgery, 142, 396-403.e3. [Google Scholar] [CrossRef] [PubMed]
[11] Rajan, V.P. and Menon, K.M. (1985) Involvement of Microtubules in Lipoprotein Degradation and Utilization for Steroidogenesis in Cultured Rat Luteal Cells. Endocrinology, 117, 2408-2416. [Google Scholar] [CrossRef] [PubMed]
[12] Rainey, W.E., Kramer, R.E., Mason, J.I., et al. (1985) The Effects of Taxol, a Microtubule-Stabilizing Drug, on Steroidogenic Cells. Journal of Cellular Physiology, 123, 17-24. [Google Scholar] [CrossRef] [PubMed]
[13] Vehmanen, L., Saarto, T., Blomqvist, C., Taskinen, M.-R. and Elomaa, I. (2004) Tamoxifen Treatment Reverses the Adverse Effects of Chemotherapy-Induced Ovarian Failure on Serum Lipids. British Journal of Cancer, 91, 476-481. [Google Scholar] [CrossRef] [PubMed]
[14] Kim, J., Monica, M., Kon, K.K., et al. (2006) Reciprocal Relationships between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms. Circulation, 113, 1888-1904. [Google Scholar] [CrossRef
[15] Tian, W., Yao, Y.H., Fan, G.C., et al. (2019) Changes in Lipid Profiles during and after (Neo)adjuvant Chemotherapy in Women with Early-Stage Breast Cancer: A Retrospective Study. PLoS ONE, 14, e0221866. [Google Scholar] [CrossRef] [PubMed]
[16] Hana, K., Bohuslav, M., Leo, U., et al. (2011) Intima-Media Thickness, Myocardial Perfusion and Laboratory Risk Factors of Atherosclerosis in Patients with Breast Cancer Treated with Anthracycline-Based Chemotherapy. Medical Oncology (Northwood, London, England), 28, 1281-1287. [Google Scholar] [CrossRef] [PubMed]
[17] 张艳利, 陈茂山, 杨光伦. 血清血脂和脂蛋白水平与乳腺癌发生及其临床病理学特征的相关性分析[J]. 中国普外基础与临床杂志, 2018, 25(2): 171-177.
[18] 沈金闻. pT1-2期乳腺癌患者血脂水平与腋淋巴结转移的相关性研究[D]: [博士学位论文]. 杭州: 浙江大学, 2013.
[19] 郭莉, 刘鹏熙, 陈前军, 等. 复发转移性乳腺癌血脂代谢变化的临床研究[J]. 辽宁中医杂志, 2010, 37(10): 1980-1982.
[20] 李薇. 乳腺癌患者的营养治疗专家共识[J]. 肿瘤代谢与营养电子杂志, 2021, 8(4): 374-379.
[21] Oh, J.-K., Sandin, S., Ström, P., et al. (2015) Prospective Study of Breast Cancer in Relation to Coffee, Tea and Caffeine in Sweden. International Journal of Cancer, 137, 1979-1989. [Google Scholar] [CrossRef] [PubMed]
[22] 马飞, 徐兵河, 邵志敏. 乳腺癌随访及伴随疾病全方位管理指南[J]. 中华肿瘤杂志, 2019, 41(1): 29-41.
[23] Majid, H.A., Keow, L.P., Islam, T., et al. (2018) Nutritional Status of Breast Cancer Survivors 1 Year after Diagnosis: A Preliminary Analysis from the Malaysian Breast Cancer Survivorship Cohort Study. Journal of the Academy of Nutrition and Dietetics, 118, 705-713. [Google Scholar] [CrossRef] [PubMed]
[24] 王艳莉, 方玉, 辛晓伟. 202例乳腺癌患者营养状况调查[J]. 中国肿瘤临床与康复, 2014, 21(12): 1516-1518.