痤疮膏和盐酸米诺环素联合红蓝光治疗玫瑰痤疮的疗效观察

Observation on the Efficacy of Acne Cream and Minocycline Hydrochloride Combined with Red and Blue Light in the Treatment of Rose Acne

摘要: 目的：探究痤疮膏和盐酸米诺环素联合红蓝光治疗玫瑰痤疮的疗效及安全性。方法：选取2021年3月1日至2021年7月1日于青岛大学附属医院皮肤科就诊的玫瑰痤疮患者79例，随机分成对照组(n = 39例)和观察组(n = 40例)。对照组患者给予痤疮膏和盐酸米诺环素治疗，观察组患者给予痤疮膏和盐酸米诺环素联合红蓝光治疗，治疗3周和6周分别比较两组的皮损积分变化、临床疗效以及产生的不良反应。结果：经过6周治疗后，两组患者的皮损积分均较治疗前有所下降，但观察组的降低幅度明显大于对照组，并且临床疗效优于对照组，差异有统计学意义(P < 0.05)。两组患者在治疗过程中不良反应的发生率差异无统计学意义(P > 0.05)。结论：痤疮膏和盐酸米诺环素联合红蓝光明显优于仅应用痤疮膏和盐酸米诺环素治疗玫瑰痤疮，且无明显的不良反应。

Abstract: Objective: To explore the efficacy and safety of acne cream and minocycline hydrochloride combined with red and blue light in the treatment of rose acne. Methods: A total of 79 patients with rose acne treated in the Department of Dermatology, The Affiliated Hospital of Qingdao University from March 1, 2021 to July 1, 2021 were randomly divided into control group (n = 39) and observation group (n = 40). The patients in the control group were treated with acne cream and minocycline hydrochloride, and the patients in the observation group were treated with acne cream and minocycline hydrochloride combined with red and blue light. The changes of skin lesion score, clinical efficacy and adverse reactions of the two groups were compared for 3 weeks and 6 weeks respectively. Results: After 6 weeks of treatment, the skin lesion scores of the two groups were lower than those before treatment, but the decrease of the observation group was significantly higher than that of the control group, the clinical effect of the observation group was better than that of the control group, and the difference was statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: Acne cream and minocycline hydrochloride combined with red and blue light were significantly better than only acne cream and minocycline hydrochloride in the treatment of rose acne, and there was no obvious adverse reaction.