HLA与乙型肝炎病毒感染的相关研究进展
Research Progress of HLA and Hepatitis B Virus Infection
DOI: 10.12677/ACM.2022.122151, PDF,  被引量   
作者: 赵 睿：延安大学附属医院妇产科，陕西 延安；李 丽*：延安大学附属医院产科一病区，陕西 延安；张改霞：陕西中医药大学第二附属医院(西咸新区中心医院)产科一病区，陕西 咸阳
关键词: 乙型肝炎病毒；人类白细胞抗原；免疫应答；母婴阻断；Hepatitis B Virus； Human Leukocyte Antigen； Immune Response； Mother-to-Child Block
摘要: 乙型肝炎病毒(hepatitis B virus, HBV)感染到目前为止仍然是一个全世界范围内有待解决的问题。HBV的母婴传播是其最常见的传播途径，据估计经此途径感染HBV的人口数占慢性感染者的40%~50%，因而要控制HBV感染最关键的步骤在于成功阻断其母婴传播。国内外研究报道表明HLA分子的表达在儿童、成人HBV感染以及慢性HBV感染所致的肝硬化、肝癌中都起着调节作用，这也为我们探究阻断HBV母婴传播，控制其感染慢性化提供了新的思路。
Abstract: Hepatitis B virus (HBV) infection is still a problem to be solved all over the world. Mother-to-child transmission of HBV is the most common route of transmission. It is estimated that the number of people infected with HBV through this route accounts for 40%~50% of those chronically infected. Therefore, the most critical step to control HBV infection is to successfully block mother-to-child transmission. Research reports at home and abroad show that the expression of HLA molecules plays a regulatory role in HBV infection both in children and adults, as well as in liver cirrhosis and liver cancer caused by chronic HBV infection, which also provides a new idea for us to explore blocking mother-to-child transmission of HBV and controlling the chronicity of HBV infection.
文章引用：赵睿, 李丽, 张改霞. HLA与乙型肝炎病毒感染的相关研究进展[J]. 临床医学进展, 2022, 12(2): 1036-1039. https://doi.org/10.12677/ACM.2022.122151

参考文献

[1] 孙方彪. 乙肝免疫球蛋白联合乙肝疫苗对母婴乙肝病毒传播的防治[J]. 中国卫生标准管理, 2020, 11(20): 12-14.
[2] 中国肝炎防治基金会, 中华医学会感染病学分会, 中华医学会肝病学分会. 阻断乙型肝炎病毒母婴传播临床管理流程(2021年) [J]. 中华传染病杂志, 2021, 39(3): 6.
[3] Vittal, A. and Ghany, M. (2019) WHO Guidelines for Prevention, Care and Treatment of Individuals Infected with HBV: A US Perspective. Clinics in Liver Disease, 23, 417-432. [Google Scholar] [CrossRef] [PubMed]
[4] 吴维东, 李勤, 漆莉, 赵寒, 李柏松, 杨琳, 王菊, 等. 2016-2020年重庆市乙型病毒性肝炎时空流行特征分析[J]. 疾病监测, 2021(37): 1-6.
[5] 王崇. 乙型肝炎病毒母婴传播的阻断及免疫阻断失败母子病毒准种的检测[D]: [博士学位论文]. 长春: 吉林大学, 2017.
[6] Lumley, S.F., Mcnaughton, A.L., Paul, K., Lythgoe, K.A. and Matthews, P.C. (2018) Hepatitis B Virus Adaptation to the CD8+ T Cell Response: Consequences for Host and Pathogen. Frontiers in Immunology, 9, Article No. 1561. [Google Scholar] [CrossRef] [PubMed]
[7] Isogawa, M. and Tanaka, Y. (2015) Immunobiology of Hepatitis B Virus Infection. Hepatology Research, 45, 179-189. [Google Scholar] [CrossRef] [PubMed]
[8] 姚耀, 刘建波, 柴梅. HLA复合体与HBV感染及转归的关系[J]. 现代中西医结合杂志, 2018, 27(27): 5.
[9] Robinson, J., Halliwell, J., Hayhurst, J., Flicek, P., Parham, P. and Marsh, S. (2015) The IPD and IMGT/HLA Database: Allele Variant Databases. Nucleic Acids Research, 43, D423-D431. [Google Scholar] [CrossRef] [PubMed]
[10] Zheng, Z. (2014) Human Genes Involved in Hepatitis B Virus Infection. World Journal of Gastroenterology, 20, 7696-7706. [Google Scholar] [CrossRef] [PubMed]
[11] 张海燕, 袁福兵, 周学士, 吴桂香, 戴亚新, 徐满琴. HLA-DRB1基因多态性与HBV感染的关联性[J]. 中华医院感染学杂志, 2021, 31(18): 2730-2733.
[12] 黄歆. HLA基因遗传变异与儿童乙肝感染的流行病学研究[D]: [硕士学位论文]. 重庆: 重庆医科大学, 2016.
[13] 姚琳, 佘芹, 尹玉竹. HBV母婴阻断失败儿童的HLA基因多态性研究——附12例报告[J]. 新医学, 2018, 49(5): 341-345.
[14] Iannacone, M. and Guidotti, L. (2021) Immunobiology and Pathogenesis of Hepatitis B Virus Infection. Nature Reviews Immunology, 22, 19-32. [Google Scholar] [CrossRef] [PubMed]
[15] Guidotti, L.G. and Chisari, F.V. (2006) Immunobiology and Pathogenesis of Viral Hepatitis. Annual Review of Pathology, 1, 23-61. [Google Scholar] [CrossRef] [PubMed]
[16] Hu, Z., Liu, Y., Zhai, X., Dai, J. and Shen, H. (2013) New Loci Associated with Chronic Hepatitis B Virus Infection in Han Chinese. Nature Genetics, 45, 1499-1503. [Google Scholar] [CrossRef] [PubMed]
[17] Zhu, M., Dai, J., Wang, C., Wang, Y., Qin, N., Ma, H., Song, C., Zhai, X., Yang, Y. and Liu, J. (2016) Fine Mapping the MHC Region Identified Four Independent Variants Modifying Susceptibility to Chronic Hepatitis B in Han Chinese. Human Molecular Genetics, 25, 1225-1232. [Google Scholar] [CrossRef] [PubMed]
[18] O’Brien, K. and Pfeiffer, M. (2011) Risk Alleles for Chronic Hepatitis B Are Associated with Decreased mRNA Expression of HLA-DPA1 and HLA-DPB1 in Normal Human Liver. Genes & Immunity, 12, 428-433. [Google Scholar] [CrossRef] [PubMed]
[19] Zhang, D., Cheng, L., Badner, J.A., Chen, C., Chen, Q., Luo, W., Craig, D.W., Redman, M., Gershon, E.S. and Liu, C. (2010) Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain. The American Journal of Human Genetics, 86, 411-419. [Google Scholar] [CrossRef] [PubMed]
[20] Pisaturo, M., Di Caprio, G., Calò, F., Portunato, F., Martini, S. and Coppola, N. (2018) Management of HBV Reactivation in Non-Oncological Patients. Expert Review of Anti-Infective Therapy, 16, 611-624. [Google Scholar] [CrossRef] [PubMed]
[21] Matsuda, H., Hiramatsu, K., Akazawa, Y., Nosaka, T., Saito, Y., Ozaki, Y., Hayama, R., Takahashi, K., Naito, T. and Ofuji, K. (2018) Genetic Polymorphism and Decreased Expression of HLA Class II DP Genes Are Associated with HBV Reactivation in Patients Treated with Immunomodulatory Agents. Journal of Medical Virology, 90, 712. [Google Scholar] [CrossRef] [PubMed]

为你推荐