黑素瘤BRAF抑制剂耐药与细胞自噬的相关性
Correlation between Autophagy and Drug Resistance of Melanoma BRAF Inhibitors
DOI: 10.12677/ACM.2022.122152, PDF,    科研立项经费支持
作者: 刘 添, 王永晨*:哈尔滨医科大学附属第二医院皮肤科,黑龙江 哈尔滨
关键词: 黑素瘤细胞自噬BRAF抑制剂耐药性Melanoma Cell Autophagy BRAF Inhibitor Drug Resistance
摘要: 黑素瘤是一种源于黑素细胞的致命性肿瘤,原发灶常见于皮肤。近年的多项研究表明,黑素瘤的发生和发展与原癌基因BRAF突变激活密切相关,所以多种针对BRAF突变的靶向药物相继问世,如威罗菲尼和达拉菲尼,临床上取得了很好的治疗效果,但BRAF抑制剂的耐药问题又成为亟需解决的难题。本文就BRAF抑制剂的耐药机制与细胞自噬的相关性及黑素瘤治疗的研究进展予以综述。
Abstract: Melanoma is a deadly tumor that originates from melanocytes, which often occurs in the skin. In recent years, many studies have shown that the occurrence and development of melanoma are closely related to the mutation of proto-oncogene BRAF. So, a variety of targeted drugs for BRAF mutation were successively published, such as Vemurafenib and Darafenib, which had good treatment effect in clinical trials. However, how to solve the resistance of BRAF inhibitor has become a difficult problem. This article reviews the relationship between the mechanism of BRAF inhibitor resistance and autophagy and the research progress of melanoma treatment.
文章引用:刘添, 王永晨. 黑素瘤BRAF抑制剂耐药与细胞自噬的相关性[J]. 临床医学进展, 2022, 12(2): 1040-1045. https://doi.org/10.12677/ACM.2022.122152

参考文献

[1] Pourhanifeh, M.H., Abbaszadeh-Goudarzi, K., Goodarzi, M., et al. (2019) Resveratrol: A New Potential Therapeutic Agent for Melanoma? Current Medicinal Chemistry, 19, 1878-1886.
[2] Czarnecki, D. (2014) The Incidence of Melanoma Is Increasing in the Susceptible Young Australian Population. Acta Dermato-Venereologica, 94, 539-541.
[3] Wadt, K.A., Drzewiecki, K.T. and Gerdes, A.M. (2015) High Accuracy of Family History of Melanoma in Danish Melanoma Cases. Familial Cancer, 14, 609-613. [Google Scholar] [CrossRef] [PubMed]
[4] Xiao, Q., Ying, J., Qiao, Z., et al. (2020) Exogenous Hydrogen Sulfide Inhibits Human Melanoma Cell Development via Suppression of the PI3K/AKT/mTOR Pathway. Journal of Dermatological Science, 98, 26-34.
[5] Stigall, L.E., Brodland, D.G. and Zitelli, J.A. (2016) The Use of Mohs Micrographic Surgery (MMS) for Melanoma in Situ (MIS) of the Trunk and Proximal Extremities. Journal of the American Academy of Dermatology, 75, 1015-1021.
[6] Raigani, S., Cohen, S. and Boland, G.M. (2017) The Role of Surgery for Melanoma in an Era of Effective Systemic Therapy. Current Oncology Reports, 19, Article No. 17. [Google Scholar] [CrossRef] [PubMed]
[7] 中国医疗保健国际交流促进会华夏皮肤影像人工智能协作组, 中国医疗保健国际交流促进会皮肤科分会皮肤影像学组, 中国中西医结合学会皮肤性病专业委员会皮肤影像学组, 等. 中国皮肤恶性黑素瘤皮肤镜特征专家共识[J]. 中华皮肤科杂志, 2020, 53(6): 401-408. [Google Scholar] [CrossRef
[8] Koshenkov, V.P., Broucek, J. and Kaufman, H.L. (2016) Surgical Management of Melanoma. In: Kaufman, H. and Mehnert, J., Eds., Melanoma, Springer, Cham, 149-179. [Google Scholar] [CrossRef] [PubMed]
[9] Bodenham, D.C. (1968) A Study of 650 Observed Malignant Melanomas in the South-West Region. Annals of the Royal College of Surgeons of England, 43, 218-239.
[10] Ascierto, P.A. (2015) Immunotherapies and Novel Combinations: The Focus of Advances in the Treatment of Melanoma. Cancer Immunology, Immunotherapy, 64, 271-274. [Google Scholar] [CrossRef] [PubMed]
[11] Kim, Y., Gil, J., Pla, I., et al. (2020) Protein Expression in Metastatic Melanoma and the Link to Disease Presentation in a Range of Tumor Phenotypes. Cancers, 12, 767-789. [Google Scholar] [CrossRef] [PubMed]
[12] Grahovac, J., Srdić-Rajić, T., Francisco Santibañez, J., et al. (2019) Telmisartan Induces Melanoma Cell Apoptosis and Synergizes with Vemurafenib in Vitro by Altering Cell Bioenergetics. Cancer Biology & Medicine, 16, 247-263. [Google Scholar] [CrossRef] [PubMed]
[13] Madorsky Rowdo, F.P., Barón, A., Gallagher, S.J., et al. (2020) Epigenetic Inhibitors Eliminate Senescent Melanoma BRAFV600E Cells that Survive Long-Term BRAF Inhibition. International Journal of Oncology, 56, 1429-1441. [Google Scholar] [CrossRef] [PubMed]
[14] Ide, M., Koba, S., Sueoka-Aragane, N., et al. (2017) Mutation Profile of B-Raf Gene Analyzed by Fully Automated System and Clinical Features in Japanese Melanoma Patients. Pathology and Oncology Research, 23, 181-188. [Google Scholar] [CrossRef] [PubMed]
[15] Robert, C., Karaszewska, B., Schachter, J., et al. (2015) Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib. The New England Journal of Medicine, 372, 30-39. [Google Scholar] [CrossRef
[16] 孙晓冉, 孙剑经, 张林西. 肿瘤多药耐药机制的研究进展[J]. 现代肿瘤医学, 2017, 25(1): 164-166. [Google Scholar] [CrossRef
[17] Martin, S., Dudek-Perić, A.M., Maes, H., et al. (2015) Concurrent MEK and Autophagy Inhibition Is Required to Restore Cell Death Associated Danger-Signalling in Vemurafenib-Resistant Melanoma Cells. Biochemical Pharmacology, 93, 290-304. [Google Scholar] [CrossRef] [PubMed]
[18] Adhikari, M., Adhikari, B., Ghimire, B., et al. (2020) Cold Atmospheric Plasma and Silymarin Nanoemulsion Activate Autophagy in Human Melanoma Cells. International Journal of Molecular Sciences, 21, 1939-1955. [Google Scholar] [CrossRef] [PubMed]
[19] Shang, Y.Y., Yu, N., Xia, L., et al. (2020) Augmentation of Danusertib’s Anticancer Activity against Melanoma by Blockage of Autophagy. Drug Delivery and Translational Research, 10, 136-145. [Google Scholar] [CrossRef] [PubMed]
[20] Wang, L., Guo, W., Ma, J., et al. (2018) Aberrant SIRT6 Expression Contributes to Melanoma Growth: Role of the Autophagy Paradox and IGF-AKT Signaling. Autophagy, 14, 518-533. [Google Scholar] [CrossRef] [PubMed]
[21] Barceló, C., Sisó, P., Maiques, O., et al. (2020) T-Type Calcium Channels as Potential Therapeutic Targets in Vemurafenib-Resistant BRAFV600E Melanoma. Journal of Investigative Dermatology, 140, 1253-1265. [Google Scholar] [CrossRef] [PubMed]
[22] 崔丹蕊, 刘波, 刘伟. 细胞自噬与肿瘤发生关系的研究进展[J]. 中国科学(生命科学), 2015, 45(6): 593-603. [Google Scholar] [CrossRef
[23] Perera, R.M., Di Malta, C. and Ballabio, A. (2019) MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer. Annual Review of Cancer Biology, 3, 203-222. [Google Scholar] [CrossRef] [PubMed]
[24] 许莲, 唐芬, 李玄, 等. mTOR信号通路与自噬在肿瘤中的研究进展[J]. 现代生物医学进展, 2016, 16(7): 1372-1374. [Google Scholar] [CrossRef
[25] Han, W., Pan, H., Chen, Y., et al. (2010) EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotecteve Response in Human Lung Cancer Cells. Cancer Cells, 6, e18691. [Google Scholar] [CrossRef] [PubMed]
[26] Yang, S., Xiao, X., Meng, X., et al. (2011) A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors. PLoS ONE, 6, e26343. [Google Scholar] [CrossRef] [PubMed]
[27] Herman-Antosiewicz, A., Johnson, D.E. and Singh, S.V. (2006) Sulforaphane Causes Autophagy to Inhibit Release of Cytochrome C and Apoptosis in Human Prostate Cancer Cells. Cancer Research, 66, 5828-5835. [Google Scholar] [CrossRef
[28] Valli, F., García Vior, M.C., Roguin, L.P., et al. (2020) Crosstalk between Oxidative Stress-Induced Apoptotic and Autophagic Signaling Pathways in Zn(II) Phthalocyanine Photodynamic Therapy of Melanoma. Free Radical Biology and Medicine, 152, 743-754. [Google Scholar] [CrossRef] [PubMed]
[29] Bao, Y., Ding, Z., Zhao, P., et al. (2020) Autophagy Inhibition Potentiates the Anti-EMT Effects of Alteronol through TGF-β/Smad3 Signaling in Melanoma Cells. Cell Death & Disease, 11, 223-232. [Google Scholar] [CrossRef] [PubMed]
[30] Antunes, F., Pereira, G.J.S., Saito, R.F., et al. (2020) Effective Synergy of Sorafenib and Nutrient Shortage in Inducing Melanoma Cell Death through Energy Stress. Cells, 9, 640-657. [Google Scholar] [CrossRef] [PubMed]
[31] Yu, Y., Xiang, N., Lin, M., et al. (2019) miR-26a Sensitizes Melanoma Cells to Dabrafenib via Targeting HMGB1-Dependent Autophagy Pathways. Drug Design, Development and Therapy, 13, 3717-3726. [Google Scholar] [CrossRef
[32] Nakamura, Y. and Fujisawa, Y. (2018) Diagnosis and Management of Acral Lentiginous Melanoma. Current Treatment Options in Oncology, 19, Article No. 42. [Google Scholar] [CrossRef] [PubMed]
[33] Guo, B., Zhang, Q., Wang, H., Chang, P. and Tao, K. (2018) KCNQ1OT1 Promotes Melanoma Growth and Metastasis. Aging, 10, 632-644. [Google Scholar] [CrossRef] [PubMed]
[34] Lugović-Mihić, L., Ćesić, D., Vuković, P., Novak Bilić, G., Šitum, M. and Špoljar, S. (2019) Melanoma Development: Current Knowledge on Melanoma Pathogenesis. Acta Dermatovenerologica Croatica, 27, 163-168.