内脏脂肪面积与2型糖尿病患者血管病变的相关性研究进展
Progress in the Correlation between Visceral Fat Area and Vascular Lesions in Patients with Type 2 Diabetes
摘要: 在全球范围内2型糖尿病的患病率呈逐年上升趋势，目前我国糖尿病患病率达11.2% (WHO标准)或12.8% (ADA标准)。造成糖尿病大流行的原因是多方面的，包括人口老龄化、不健康饮食以及不良生活方式等。糖尿病及其慢性并发症带给患者及其家庭巨大的经济及心理负担，其中血管病变是最常见的糖尿病慢性并发症。有研究表示内脏脂肪与2型糖尿病的发生发展有关。内脏脂肪面积可能在糖尿病血管病变中起重要作用，通过研究两者关系，可以为临床早期防治糖尿病血管病变提供新思路。基于此，本文就内脏脂肪面积与2型糖尿病患者血管病变的相关性研究展开综述。
Abstract: The prevalence of type 2 diabetes worldwide is increasing year by year. At present, the prevalence of diabetes in China is 11.2% (WHO standard) or 12.8% (ADA standard). The diabetes epidemic is driven by many factors, including ageing populations, unhealthy diets and poor lifestyles. Diabetes and its chronic complications bring enormous economic and psychological burden to patients and their families, among which vascular disease is the most common chronic complication of diabetes. Studies have shown that visceral fat is related to the occurrence and development of type 2 diabetes. Visceral fat area may play an important role in diabetic vascular disease. The study of the relationship between the two can provide new ideas for early clinical prevention and treatment of diabetic vascular diseases. Based on this, this paper reviews the correlation between visceral fat area and vascular lesions in type 2 diabetes patients.
文章引用：栾敬红, 李社莉. 内脏脂肪面积与2型糖尿病患者血管病变的相关性研究进展[J]. 临床医学进展, 2022, 12(2): 1046-1050. https://doi.org/10.12677/ACM.2022.122153

参考文献

[1] Cho, N.H., Shaw, J.E., Karuranga, S., et al. (2018) IDF Diabetes Atlas: Global Estimates of Diabetes Prevalence for 2017 and Projections for 2045. Diabetes Research and Clinical Practice, 138, 271-281. [Google Scholar] [CrossRef] [PubMed]
[2] Saeedi, P., Petersohn, I., Salpea, P., et al. (2019) Global and Regional Diabetes Prevalence Estimates for 2019 and Projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th Edition. Diabetes Research and Clinical Practice, 157, Article ID: 107843. [Google Scholar] [CrossRef] [PubMed]
[3] Zheng, Y., Ley, S.H. and Hu, F.B. (2018) Global Aetiology and Epidemiology of Type 2 Diabetes Mellitus and Its Complications. Nature Reviews Endocrinology, 14, 88-98. [Google Scholar] [CrossRef] [PubMed]
[4] 中华医学会内分泌学分会. 中国2型糖尿病合并肥胖综合管理专家共识[J]. 中华内分泌代谢杂志, 2016, 32(8): 623-627.
[5] 任晨曦, 张婕, 徐佰慧, 等. 中年人内脏脂肪含量与2型糖尿病的相关性研究[C]//中华医学会. 中华医学会第十一次全国内分泌学学术会议论文汇编. 北京: 中华医学会, 2012: 375.
[6] Li, C.L., Lin, Y., Luo, R.F., et al. (2016) Intrarenal Renin-Angiotensin System Mediates Fatty Acid-Induced ER Stress in the Kidney. American Journal of Physiology—Renal Physiology, 310, F351-F363. [Google Scholar] [CrossRef] [PubMed]
[7] Chang, K.T., Chen, C.H., Chuang, H.H., et al. (2018) Which Obesity Index Is the Best Predictor for High Cardiovascular Disease Risk in Middle-Aged and Elderly Population? Archives of Gerontology and Geriatrics, 78, 165-170.
[8] 江阳珍. 2型糖尿病患者内脏脂肪含量与白介素6、胰岛素抵抗及糖尿病慢性并发症的相关性研究[D]: [硕士学位论文]. 南昌: 南昌大学, 2021.
[9] 熊慧勤, 张鹏宇, 栗夏莲, 等. 2型糖尿病患者腹部脂肪分布与糖尿病并发症的相关性研究[J]. 中华内分泌代谢杂志, 2020, 36(4): 299-303.
[10] 王看然, 叶小琦, 王越, 等. 身体成分与2型糖尿病患者微血管病变的相关因素分析[J]. 中华糖尿病杂志, 2018, 10(4): 263-268.
[11] 王艺嵘. 2型糖尿病患者腹部脂肪分布与慢性肾脏病的相关性研究[D]: [硕士学位论文]. 兰州: 兰州大学, 2021.
[12] Sun, K., Lin, D.Z., Li, F., et al. (2019) Visceral Adiposity Index Is Associated with Increased Urinary Albumin Excretion: A Population-Based Study. Clinical Nutrition, 38, 1332-1338. [Google Scholar] [CrossRef] [PubMed]
[13] Hanai, K., Babazono, T., Nyumura, I., et al. (2010) Involvement of Visceral Fat in the Pathogenesis of Albuminuria in Patients with Type 2 Diabetes with Early Stage of Nephropathy. Clinical and Experimental Nephrology, 14, 132-136. [Google Scholar] [CrossRef] [PubMed]
[14] Kim, S.R., Yoo, J.H., Song, H.C., et al. (2011) Relationship of Visceral and Subcutaneous Adiposity with Renal Function in People with Type 2 Diabetes Mellitus. Nephrology Dialysis Transplantation, 26, 3550-3555. [Google Scholar] [CrossRef] [PubMed]
[15] Manabe, S., Kataoka, H., Mochizuki, T., et al. (2021) Impact of Visceral Fat Area in Patients with Chronic Kidney Disease. Clinical and Experimental Nephrology, 25, 608-620. [Google Scholar] [CrossRef] [PubMed]
[16] Anan, F., Masaki, T., Ito, Y., et al. (2010) Diabetic Retinopathy Is Associated with Visceral Fat Accumulation in Japanese Type 2 Diabetes Mellitus Patients. Metabolism, 59, 314-319. [Google Scholar] [CrossRef] [PubMed]
[17] 柳怡莹, 万沁. 糖尿病患者内脏脂肪面积与糖尿病视网膜病变的相关性研究[J]. 医学研究杂志, 2020, 49(5): 72-75.
[18] 佟凤芝, 王娜, 金丹. 血清脂联素水平在2型糖尿病视网膜病变诊治中的作用[J]. 中国全科医学, 2018, 21(S2): 131-132.
[19] Qu, G.B., Wang, L.L., Tang, X., et al. (2017) The Association between Vitamin D Level and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus: An Update Systematic Review and Meta-Analysis. Journal of Clinical & Translational Endocrinology, 9, 25-31. [Google Scholar] [CrossRef] [PubMed]
[20] Bittel, D.C., Bittel, A.J., Tuttle, L.J., et al. (2015) Adipose Tissue Content, Muscle Performance and Physical Function in Obese Adults with Type 2 Diabetes Mellitus and Peripheral Neuropathy. Journal of Diabetes and Its Complications, 29, 250-257. [Google Scholar] [CrossRef] [PubMed]
[21] Román-Pintos, L.M., Villegas-Rivera, G., Rodríguez-Carrizalez, A.D., et al. (2016) Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function. Journal of Diabetes Research, 2016, Article ID: 3425617. [Google Scholar] [CrossRef] [PubMed]
[22] 陈燕妮. 2型糖尿病患者内脏脂肪面积与糖尿病周围神经病变的相关性研究[D]: [硕士学位论文]. 福州: 福建医科大学, 2021.
[23] 黄雪, 张娟, 赵晓宏. 血同型半胱氨酸对2型糖尿病合并亚临床甲减患者外周血管斑块 的临床意义[J]. 中国医师杂志, 2021, 23(3): 379-383.
[24] 蔡金玲, 王玉荣, 田勇. 同型半胱氨酸、内脏脂肪面积与2型糖尿病患者大血管病变的相关性分析[J]. 临床医学工程, 2021, 28(12): 1663-1664.
[25] 汪琼, 金国玺, 裴晓艳, 等. 内脏脂肪面积、血清胱抑素C与2型糖尿病颈动脉硬化的关系[J]. 蚌埠医学院学报, 2021, 46(8): 1000-1003.
[26] Bouchi, R., Minami, I., Ohara, N., et al. (2015) Impact of Increased Visceral Adiposity with Normal Weight on the Progression of Arterial Stiffness in Japanese Patients with Type 2 Diabetes. BMJ Open Diabetes Research & Care, 3, e000081. [Google Scholar] [CrossRef] [PubMed]
[27] 戴梅清, 徐梦娇, 赵丽, 等. 2型糖尿病患者腹腔内脏脂肪面积与冠状动脉钙化的相关性研究[J]. 中国糖尿病杂志, 2020, 28(9): 675-679.

为你推荐