经颅直流电刺激对2型糖尿病合并轻度认知功能障碍的影响

Effect of Transcranial Direct Current Stimulation on Type 2 Diabetes Mellitus with Mild Cognitive Impairment

摘要: 目的：探讨经颅直流电刺激对2型糖尿病合并轻度认知功能障碍的临床效果。方法：回顾性分析了我院2020年6月~2021年9月就诊的100例2型糖尿病合并早期认知功能障碍患者的临床资料，对照组与实验组均给予常规降糖药物，实验组额外给予经颅直流电刺激，于治疗前、治疗4周及治疗结束后3月检测2组患者认知功能情况；采用蒙特利尔认知评估量表：评估认知功能；听觉词语学习测验：评估记忆功能；连线测验：评估执行能力。结果：治疗4周后，实验组较对照组在MOCA评分、听觉词语学习测验(即刻记忆评分、长延迟回忆评分)以及连线测验(STT-A耗时、STT-B耗时)具有明显差异(p < 0.05)；治疗结束后3月，实验组较对照组在MOCA评分、听觉词语学习测验(即刻记忆评分、长延迟回忆评分、再认测试评分)以及连线测验(STT-A耗时、STT-B耗时)具有明显差异(p < 0.05)。结论：经颅直流电刺激能有效地改善2型糖尿病合并轻度认知功能障碍的症状，值得临床应用。

Abstract: Objective: To investigate the clinical effect of transcranial direct current stimulation on type 2 diabetes mellitus with mild cognitive impairment. Methods: The clinical data of 100 patients with type 2 diabetes mellitus complicated with early cognitive impairment treated in our hospital in June 2020~September 2021 were retrospectively analyzed. The control group and the experimental group were given conventional hypoglycemic drugs. The experimental group received transcranial direct current stimulation, and the cognitive function of the 2 groups was detected before treatment, 4 weeks and 3 months after treatment. Montreal cognitive assessment scale was used to evaluate cognitive function; auditory verbal learning test: evaluate memory function; STT: evaluate executive ability. Results: After 4 weeks of treatment, the experimental group showed significant differences (p < 0.05) in MOCA scores, auditory verbal learning tests (immediate memory scores, long delayed recall scores) and STT (STT-A time-consuming, STT-B time-consuming) compared to the control group. At 3 months after the end of treatment, the experimental group showed significant differences (p < 0.05) in MOCA scores, auditory verbal learning tests (immediate memory scores, long delayed recall scores, recognition test scores) and STT (STT-A time spent, STT-B time spent) compared with the control group. Conclusion: Transcranial direct current stimulation can effectively improve the symptoms of type 2 diabetes mellitus with mild cognitive impairment, and is worthy of clinical application.