宏基因组二代测序技术在感染性疾病中的临床应用进展
Progress in Clinical Application of Metagenomic Next-Generation Sequencing Technology in Infectious Disease
DOI: 10.12677/ACM.2022.122176, PDF,    科研立项经费支持
作者: 赵 洪, 杨光路:内蒙古医科大学附属医院,内蒙古 呼和浩特
关键词: 宏基因组二代测序技术感染性疾病病原体Metagenomic Next-Generation Sequencing Infectious Diseases Pathogen
摘要: 几乎所有的感染源都含有DNA或RNA基因组,使得测序成为一种有吸引力的病原体检测方法。宏基因组二代测序(Metagenomic next-generation sequencing, mNGS)正越来越多地应用于临床中,能否成为下一个常规的病原体检测工具已成为了人们关注的话题。mNGS方法直接从患者的临床样本中识别病原体。本综述主要从mNGS在中枢神经系统、肺部、血液、骨关节、尿路感染中的临床应用进行阐述。
Abstract: Almost all sources of infection contain DNA or RNA genomes, making sequencing an attractive method for detecting pathogens. mNGS is being used more and more in clinic, and whether it can become the next routine pathogen identification tool has become a topic of concern. The mNGS method identifies pathogens directly from patients’ clinical samples. This review focuses on the clinical application of mNGS in central nervous system, lung, blood, bone joint and urinary tract infections.
文章引用:赵洪, 杨光路. 宏基因组二代测序技术在感染性疾病中的临床应用进展[J]. 临床医学进展, 2022, 12(2): 1217-1221. https://doi.org/10.12677/ACM.2022.122176

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