皮肤微生物与银屑病发病相关性的研究进展

Research Progress on the Correlation between Skin Microbiome and Pathogenesis of Psoriasis

摘要: 银屑病的病因极其复杂，涉及遗传、免疫与环境等多种因素。近年来越来越多的研究发现，银屑病患者存在皮肤微生物群失调，发病机制可能涉及对皮肤微生物免疫耐受的崩溃。但这些研究在取样方法、部位和微生物分析方法上各持己见，尚无统一标准。迄今为止尚未发现皮肤微生物和银屑病之间的相关性，即微生物的组成变化是否与银屑病的发病具有因果关系。本文对国内外利用现代测序技术鉴定银屑病皮肤微生物多样性的研究进行梳理和分析，旨在了解银屑病发病机制，明确当前的研究进展和存在的问题，为进一步的研究提出建议。

Abstract: Psoriasis is a disease with complex etiology and its pathogenesis involves a variety of factors such as heredity, immunity and environment. In recent years, more and more studies have shown that patients with psoriasis have obvious dysbiosis of skin microbiome. The pathogenesis of psoriasis may involve the collapse of immune tolerance to skin microbiome. However, these studies are different in sampling methods, sampling sites and microbial analysis methods and there is no unified standard. So far, no clear link has been found between skin microbiome and psoriasis and whether there is a causal relationship between changes in microbial composition and psoriasis. In this review, the domestic and foreign studies on the identification of skin microbial diversity of psoriasis by modern sequencing technology were summarized and analyzed, aiming to understand the pathogenesis of psoriasis, clarify the current research progress and existing problems, and put forward suggestions for further research.