MOG抗体阳性与阴性的急性播散性脑脊髓炎对比研究进展
Research Progress in Differences between Acute Disseminated Encephalomyelitis with Positive and Negative MOG Antibodies
DOI: 10.12677/ACM.2022.122190, PDF,   
作者: 董雪珊：重庆医科大学附属儿童医院神经内科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿科学重庆市重点实验室，重庆
关键词: 急性播散性脑脊髓炎(ADEM)；抗髓鞘少突胶质细胞糖蛋白抗体(MOG-Ab)；研究进展；Acute Disseminated Encephalomyelitis (ADEM)； Myelin Oligodendrocyte Glycoprotein Antibody (MOG-Ab)； Research Progress
摘要: 急性播散性脑脊髓炎(ADEM)是一种罕见的中枢神经系统脱髓鞘疾病，以脑病、多灶性神经功能缺损以及特征性影像特征为主要特点，其发病机制尚未完全明确。近年的重要进展是抗髓鞘少突胶质细胞糖蛋白抗体(MOG-Ab)与ADEM及其相关复发形式之间的关系逐渐被认识到，但MOG抗体阳性相对于MOG抗体阴性的ADEM患者的临床、影像、治疗及预后特征仍不明确，相关的对比研究很少，且尚无文献总结其结论。对于MOG抗体在ADEM中的角色仍难以得到统一的认识。因此，本文对伴或不伴MOG抗体的ADEM的对比研究进展做一综述，以提高临床医生对该病的认识以及指导临床诊治，并对未来研究方向进行了简单的展望。
Abstract: Acute disseminated encephalomyelitis (ADEM) is a rare demyelinating disease of the central nervous system, characterized by encephalopathy, multifocal neurological deficits, and typical imaging features, whose pathogenesis is not yet fully understood. An important development in recent years is that the relationship between anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab) and ADEM and its related recurrence forms has gradually been recognized. However, the clinical, imaging, treatment, and prognostic characteristics of ADEM patients with positive MOG antibodies compared with those with negative MOG antibodies are still unclear. It is still difficult to get a unified understanding of the role of MOG antibody in ADEM. Therefore, our article reviewed the comparative research progress of ADEM with or without MOG antibody, aiming to improve clinicians’ understanding of the disease and guide clinical diagnosis and treatment, and briefly prospected for future research directions.
文章引用：董雪珊. MOG抗体阳性与阴性的急性播散性脑脊髓炎对比研究进展[J]. 临床医学进展, 2022, 12(2): 1306-1312. https://doi.org/10.12677/ACM.2022.122190

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