血清尿酸及肌酐在双相情感障碍与抑郁症急性发作期中的检测分析

Analysis of Serum Uric Acid and Creatinine in Acute Episode of Bipolar Disorder and Depressive Disorder

摘要: 目的：研究血清尿酸与肌酐在双相情感障碍(bipolar disorder, BD)与抑郁症(depressive disorder, DD)临床意义。方法：纳入BD患者86例，DD患者73例，对照组健康查体人员66名，分别测定患者急性发作期时及对照组查体人员血清尿酸及肌酐数值，比较三组被试血清尿酸及肌酐水平。结果：三组研究对象尿酸及肌酐水平存在统计学差异(P < 0.05)，其中BD组急性发作期尿酸、肌酐水平均高于DD组(P < 0.05)；BD组五个不同分型(伴精神病性躁狂发作、不伴精神病性躁狂发作、伴精神病性抑郁发作、不伴精神病性抑郁发作、混合发作)间尿酸及肌酐水平无统计学差异(P > 0.05)；DD组三个不同分型(伴精神病性重度抑郁发作、不伴精神病性重度抑郁发作、中度抑郁发作)尿酸及肌酐水平无明显统计学差异(P > 0.05)。其中，通过对尿酸及肌酐进行Pearson相关分析，二者呈低度正相关(r = 0.494, P < 0.001)。结论：BD患者尿酸及肌酐水平升高，DD尿酸及肌酐水平降低。提示尿酸及肌酐可能是心境障碍的血液生物学标志物。

Abstract: Objective: To study the clinical significance of serum uric acid and creatinine in patients with bipolar disorder and depression (DD). Methods: 86 BD patients, 73 DD patients and 66 healthy subjects in the control group were included in the study. Serum uric acid and creatinine levels of patients during acute attack stage and those in the control group were measured respectively, and the serum uric acid and creatinine levels of the three groups were compared. Results: There were significant differences in uric acid and creatinine levels among the three groups (P < 0.05), the levels of uric acid and creatinine in BD group were higher than those in DD group (P < 0.05); There were no statistically significant differences in uric acid and creatinine levels between BD group and five different subtypes (with psychotic manic episode, without psychotic manic episode, with psychotic depressive episode, without psychotic depressive episode and mixed episode) (P > 0.05); There were no significant differences in uric acid and creatinine levels among DD group with MDD, without MDD and WITHOUT MDD (P > 0.05). Pearson correlation analysis showed a low positive correlation between uric acid and creatinine (r = 0.494, P < 0.001). Conclusion: The levels of uric acid and creatinine in BD patients are increased, while the levels of DD uric acid and creatinine are decreased. It is suggested that uric acid and creatinine may be blood biomarkers of mood disorders.