二乙基二硫代氨基甲酸钠(DTC)与砷、锑、铋配合物的合成及其对H1299肺癌细胞生物活性的研究

Synthesis of Sodium Diethyldithiocarbamate (DTC) Complexes with Arsenic, Antimony and Bismuth and Its Bioactivity on H1299 Lung Cancer Cells

摘要: 本论文用室温液液反应合成了DTC与砷、锑、铋的生物配合物，其分别对应三种活性药物。测定了配合物的粉末X-射线衍射图谱，并用计算机程序对图谱进行了指标化，确定了配合物所属晶系和晶胞参数；通过元素分析确定了配合物的组成；用1HNMR研究了金属离子和生物配体的配位情况；用差热–热重分析研究了配合物热分解过程及成键行为；并对三种砷的生物配合物进行了H1299肺癌细胞生物活性实验研究，结果表明：合成的配合物比单用配体和碘化砷对肺癌细胞的抑制作用都强。

Abstract: In this paper, the biological complexes of DTC with arsenic, antimony and bismuth were synthesized by liquid-liquid reaction at room temperature, which correspond to three active drugs respectively. The powder X-ray diffraction pattern of the complex was determined, the pattern was indexed by computer program, and the crystal system and cell parameters of the complex were determined; the composition of the complex was determined by elemental analysis; the coordination of metal ions with biological ligands was studied by 1HNMR; the thermal decomposition process and bonding behavior of the complexes were studied by differential thermal gravimetric analysis; the biological activity experiments of H1299 lung cancer cells were carried out for the three biological complexes of arsenic. The results showed that the synthetic complexes had stronger inhibitory effects on lung cancer cells than ligands and arsenic iodide alone.