胆总管结石复发危险因素研究进展
Advances in Risk Factors for Recurrence of Choledocholithiasis
DOI: 10.12677/ACM.2022.122213, PDF,   
作者: 王可驹, 吴传新*:重庆医科大学附属第二医院肝胆外科,重庆;孙 航:重庆医科大学附属第二医院病毒性肝炎研究所,重庆
关键词: 胆总管结石复发危险因素Choledocholithiasis Recurrence Risk Factors
摘要: 胆总管结石是我国的一种常见良性疾病,可导致患者出现梗阻性黄疸、胆管炎、胰腺炎甚至胆管癌等并发症。目前胆总管结石的治疗方法主要包括内镜逆行胰胆管造影术和腹腔镜胆总管探查术,虽然结石清除率可高达95%,但其术后复发率约为4%~24%。本文就手术相关的因素、胆道解剖结构、结石的特质、性别年龄等方面对胆总管结石复发的危险因素进行深入探讨。
Abstract: Choledocholithiasis is a common benign disease in China, which can lead to complications such as obstructive jaundice, cholangitis, pancreatitis and even cholangiocarcinoma. At present, the treatment of choledocholithiasis mainly includes endoscopic retrograde cholangiopancreatography and laparoscopic or open bile duct exploration. Although the stone clearance rate can be as high as 95%, the postoperative recurrence rate is about 4%~24%. This study makes an in-depth discussion on the risk factors of choledocholithiasis recurrence from the aspects of operation-related factors, biliary anatomical structure, characteristics of stones, sex and age, etc.
文章引用:王可驹, 孙航, 吴传新. 胆总管结石复发危险因素研究进展[J]. 临床医学进展, 2022, 12(2): 1473-1481. https://doi.org/10.12677/ACM.2022.122213

参考文献

[1] Tazuma, S. (2006) Gallstone Disease: Epidemiology, Pathogenesis, and Classification of Biliary Stones (Common Bile Duct and Intrahepatic). Best Practice & Research: Clinical Gastroenterology, 20, 1075-1083. [Google Scholar] [CrossRef] [PubMed]
[2] Peng, L.J., Cheng, X.N. and Zhang, L. (2020) Risk Factors of Stone Recurrence after Endoscopic Retrograde Cholangiopancreatography for Common Bile Duct Stones. Medicine (Baltimore), 99, e20412. [Google Scholar] [CrossRef
[3] Sbeit, W., Kadah, A., Simaan, M., et al. (2022) Predictors of Recurrent Bile Duct Stone after Clearance by Endoscopic Retrograde Cholangiopancreatography: A Case-Control Study. Hepatobiliary & Pancreatic Diseases International, 21, 50-55.
[4] Park, S.Y., Hong, T.H., Lee, S.K., et al. (2019) Recurrence of Common Bile Duct Stones Following Laparoscopic Common Bile Duct Exploration: A Multicenter Study. Journal of Hepato-Biliary-Pancreatic Sciences, 26, 578-582. [Google Scholar] [CrossRef] [PubMed]
[5] Yasuda, I., Fujita, N., Maguchi, H., et al. (2014) Long-Term Outcomes after Endoscopic Sphincterotomy versus Endoscopic Papillary Balloon Dilation for Bile Duct Stones. Gastrointestinal Endoscopy, 72, 1185-1191. [Google Scholar] [CrossRef] [PubMed]
[6] Choi, S.J., Yoon, J.H., Koh, D.H., et al. (2021) Low Insertion of Cystic Duct Increases Risk for Common Bile Duct Stone Recurrence. Surgical Endoscopy, 6.
[7] Baiu, I. and Visser, B. (2018) Endoscopic Retrograde Cholangiopancreatography. JAMA, 320, 2050. [Google Scholar] [CrossRef] [PubMed]
[8] Wang, F., Xu, B., Li, Q., et al. (2016) Endoscopic Retrograde Cholangiopancreatography in Patients with Surgically Altered Anatomy: One Single Center’s Experience. Medicine (Baltimore), 95, e5743. [Google Scholar] [CrossRef
[9] Doi, S., Yasuda, I., Mukai, T., et al. (2013) Comparison of Long-Term Outcomes after Endoscopic Sphincterotomy versus Endoscopic Papillary Balloon Dilation: A Propensity Score-Based Cohort Analysis. Journal of Gastroenterology, 48, 1090-1096. [Google Scholar] [CrossRef] [PubMed]
[10] Takimoto, Y., Irisawa, A., Hoshi, K., et al. (2021) The Impact of Endoscopic Sphincterotomy Incision Size on Common Bile Duct Stone Recurrence: A Propensity Score Matching Analysis. Journal of Hepato-Biliary-Pancreatic Sciences, 11.
[11] Yasuda, I., Tomita, E., Enya, M., et al. (2001) Can Endoscopic Papillary Balloon Dilation Really Preserve Sphincter of Oddi Function? Gut, 49, 686-691. [Google Scholar] [CrossRef] [PubMed]
[12] Sato, H., Kodama, T., Takaaki, J., et al. (1997) Endoscopic Papillary Balloon Dilatation May Preserve Sphincter of Oddi Function after Common Bile Duct Stone Management: Evaluation from the Viewpoint of Endoscopic Manometry. Gut, 41, 541-544. [Google Scholar] [CrossRef] [PubMed]
[13] Mu, H., Gao, J., Kong, Q., et al. (2015) Prognostic Factors and Postoperative Recurrence of Calculus Following Small-Incision Sphincterotomy with Papillary Balloon Dilation for the Treatment of Intractable Choledocholithiasis: A 72-Month Follow-Up Study. Digestive Diseases and Sciences, 60, 2144-2149. [Google Scholar] [CrossRef] [PubMed]
[14] Jin, P.P., Cheng, J.F., Liu, D., et al. (2014) Endoscopic Papillary Large Balloon Dilation vs Endoscopic Sphincterotomy for Retrieval of Common Bile Duct Stones: A Meta-Analysis. World Journal of Gastroenterology, 20, 5548-5556. [Google Scholar] [CrossRef] [PubMed]
[15] Harada, R., Maguchi, H., Takahashi, K., et al. (2013) Large Balloon Dilation for the Treatment of Recurrent Bile Duct Stones Prevents Short-Term Recurrence in Patients with Previous Endoscopic Sphincterotomy. Journal of Hepato-Biliary-Pancreatic Sciences, 20, 498-503. [Google Scholar] [CrossRef] [PubMed]
[16] Paspatis, G.A., Paraskeva, K., Vardas, E., et al. (2017) Long-Term Recurrence of Bile Duct Stones after Endoscopic Papillary Large Balloon Dilation with Sphincterotomy: 4-Year Extended Follow-Up of a Randomized Trial. Surgical Endoscopy, 31, 650-655. [Google Scholar] [CrossRef] [PubMed]
[17] Liu, P., Lin, H., Chen, Y., et al. (2019) Comparison of Endoscopic Papillary Large Balloon Dilation with and without a Prior Endoscopic Sphincterotomy for the Treatment of Patients with Large and/or Multiple Common Bile Duct Stones: A Systematic Review and Meta-Analysis. Therapeutics and Clinical Risk Management, 15, 91-101. [Google Scholar] [CrossRef
[18] Kim, K.H., Rhu, J.H. and Kim, T.N. (2012) Recurrence of Bile Duct Stones after Endoscopic Papillary Large Balloon Dilation Combined with Limited Sphincterotomy: Long-Term Follow-Up Study. Gut Liver, 6, 107-112. [Google Scholar] [CrossRef] [PubMed]
[19] Choe, J.W., Kim, S.Y., Lee, D.W., et al. (2020) Incidence and Risk Factors for Postoperative Common Bile Duct Stones in Patients Undergoing Endoscopic Extraction and Subsequent Cholecystectomy. Gastrointestinal Endoscopy, 93, 608-615. [Google Scholar] [CrossRef] [PubMed]
[20] Endo, R., Satoh, A., Tanaka, Y., et al. (2020) Saline Solution Irrigation of the Bile Duct after Stone Removal Reduces the Recurrence of Common Bile Duct Stones. The Tohoku Journal of Experimental Medicine, 250, 173-179. [Google Scholar] [CrossRef] [PubMed]
[21] Lu, Y., Wu, J.C., Liu, L., et al. (2014) Short-Term and Long-Term Outcomes after Endoscopic Sphincterotomy versus Endoscopic Papillary Balloon Dilation for Bile Duct Stones. European Journal of Gastroenterology & Hepatology, 26, 1367-1373. [Google Scholar] [CrossRef
[22] Huang, Q., Shao, F., Wang, C., et al. (2018) Nasobiliary Drainage Can Reduce the Incidence of Post-ERCP Pancreatitis after Papillary Large Balloon Dilation plus Endoscopic Biliary Sphincterotomy: A Randomized Controlled Trial. Scandinavian Journal of Gastroenterology, 53, 114-119. [Google Scholar] [CrossRef] [PubMed]
[23] Sharma, B.C., Kumar, R., Agarwal, N., et al. (2005) Endoscopic Biliary Drainage by Nasobiliary Drain or by Stent Placement in Patients with Acute Cholangitis. Endoscopy, 37, 439-443. [Google Scholar] [CrossRef] [PubMed]
[24] Wang, Y., Yang, Y., Wang, K., et al. (2020) The Value of Contrast-Enhanced Ultrasound-Guided Contrast Injection via the Endoscopic Nasobiliary Drainage Duct in Diagnosing Residual Common Bile Duct Stones. BioMed Research International, 2020, Article ID: 3281241. [Google Scholar] [CrossRef] [PubMed]
[25] Choi, J.H., Lee, T.Y., Cheon, Y.K. (2021) Effect of Stent Placement on Stone Recurrence and Post-Procedural Cholangitis after Endoscopic Removal of Common Bile Duct Stones. The Korean Journal of Internal Medicine, 36, S27-S34. [Google Scholar] [CrossRef] [PubMed]
[26] Deng, F., Zhou, M., Liu, P.P., et al. (2019) Causes Associated with Recurrent Choledocholithiasis Following Therapeutic Endoscopic Retrograde Cholangiopancreatography: A Large Sample Sized Retrospective Study. World Journal of Clinical Cases, 7, 1028-1037. [Google Scholar] [CrossRef] [PubMed]
[27] Cheng, C.T., Yeh, C.N., Chiang, K.C., et al. (2018) Effects of Cholecystectomy on Recurrent Biliary Complications after Endoscopic Treatment of Common Bile Duct Stone: A Population-Based Cohort Study. Surgical Endoscopy, 32, 1793-1801. [Google Scholar] [CrossRef] [PubMed]
[28] Nakai, Y., Isayama, H., Tsujino, T., et al. (2016) Cholecystectomy after Endoscopic Papillary Balloon Dilation for Bile Duct Stones Reduced Late Biliary Complications: A Propensity Score-Based Cohort Analysis. Surgical Endoscopy, 30, 3014-3020. [Google Scholar] [CrossRef] [PubMed]
[29] Park, B.K., Seo, J.H., Jeon, H.H., et al. (2017) A Nationwide Population-Based Study of Common Bile Duct Stone Recurrence after Endoscopic Stone Removal in Korea. Journal of Gastroenterology, 53, 670-678. [Google Scholar] [CrossRef] [PubMed]
[30] Yasui, T., Takahata, S., Kono, H., et al. (2012) Is Cholecystectomy Necessary after Endoscopic Treatment of Bile Duct Stones in Patients Older than 80 Years of Age? Journal of Gastroenterology, 47, 65-70. [Google Scholar] [CrossRef] [PubMed]
[31] Kim, M.H., Yeo, S.J., Jung, M.K., et al. (2016) The Impact of Gallbladder Status on Biliary Complications after the Endoscopic Removal of Choledocholithiasis. Digestive Diseases and Sciences, 61, 1165-1171. [Google Scholar] [CrossRef] [PubMed]
[32] Gao, Y.C., Chen, J., Qin, Q., et al. (2017) Efficacy and Safety of Laparoscopic Bile Duct Exploration versus Endoscopic Sphincterotomy for Concomitant Gallstones and Common Bile Duct Stones: A Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore), 96, e7925. [Google Scholar] [CrossRef
[33] Al-Habbal, Y., Reid, I., Tiang, T., et al. (2020) Retrospective Comparative Analysis of Choledochoscopic Bile Duct Exploration versus ERCP for Bile Duct Stones. Scientific Reports, 10, Article No. 14736. [Google Scholar] [CrossRef] [PubMed]
[34] Tranter, S.E. and Thompson, M.H. (2002) Comparison of Endoscopic Sphincterotomy and Laparoscopic Exploration of the Common Bile Duct. British Journal of Surgery, 89, 1495-1504. [Google Scholar] [CrossRef] [PubMed]
[35] Li, S., Su, B., Chen, P., et al. (2018) Risk Factors for Recurrence of Common Bile Duct Stones after Endoscopic Biliary Sphincterotomy. Journal of International Medical Research, 46, 2595-2605. [Google Scholar] [CrossRef] [PubMed]
[36] Strnad, P., von Figura, G., Gruss, R., et al. (2013) Oblique Bile Duct Predisposes to the Recurrence of Bile Duct Stones. PLoS ONE, 8, e54601. [Google Scholar] [CrossRef] [PubMed]
[37] Zhu, T., Lin, H., Sun, J., et al. (2021) Primary Duct Closure versus T-Tube Drainage after Laparoscopic Common Bile Duct Exploration: A Meta-Analysis. Journal of Zhejiang University: Science B, 22, 985-1001. [Google Scholar] [CrossRef
[38] Ueno, N., Ozawa, Y. and Aizawa, T. (2003) Prognostic Factors for Recurrence of Bile Duct Stones after Endoscopic Treatment by Sphincter Dilation. Gastrointestinal Endoscopy, 58, 336-340. [Google Scholar] [CrossRef
[39] Chae, M.K., Lee, S.H. and Joo, K.R. (2020) Assessment of the Possible Risk Factors for Primary Common Bile Duct Stone Recurrence after Cholecystectomy. Surgical Endoscopy, 35, 6497-6504. [Google Scholar] [CrossRef] [PubMed]
[40] Yoo, E.S., Yoo, B.M., Kim, J.H., et al. (2018) Evaluation of Risk Factors for Recurrent Primary Common Bile Duct Stone in Patients with Cholecystectomy. Scandinavian Journal of Gastroenterology, 53, 466-470. [Google Scholar] [CrossRef] [PubMed]
[41] Ryu, S., Jo, I.H., Kim, S., et al. (2020) Clinical Impact of Common Bile Duct Angulation on the Recurrence of Common Bile Duct Stone: A Meta-Analysis and Review. Korean Journal of Gastroenterology, 76, 199-205. [Google Scholar] [CrossRef] [PubMed]
[42] Kao, J.T., Kuo, C.M., Chiu, Y.C., et al. (2011) Congenital Anomaly of Low Insertion of Cystic Duct: Endoscopic Retrograde Cholangiopancreatography Findings and Clinical Significance. Journal of Clinical Gastroenterology, 45, 626-629. [Google Scholar] [CrossRef
[43] Zhang, Q., Ye, M., Su, W., et al. (2020) Sphincter of Oddi Laxity Alters Bile Duct Microbiota and Contributes to the Recurrence of Choledocholithiasis. Annals of Translational Medicine, 8, 1383. [Google Scholar] [CrossRef] [PubMed]
[44] Tsai, T.J., Lin, C.K., Lai, K.H., et al. (2018) Does Preserved Sphincter of Oddi Function Prevent Common Bile Duct Stones Recurrence in Patients after Endoscopic Papillary Balloon Dilation? Journal of the Chinese Medical Association, 81, 311-315. [Google Scholar] [CrossRef] [PubMed]
[45] Kato, S., Chinen, K., Shinoura, S., et al. (2017) Predictors for Bile Duct Stone Recurrence after Endoscopic Extraction for Naïve Major Duodenal Papilla: A Cohort Study. PLoS ONE, 12, e180536. [Google Scholar] [CrossRef] [PubMed]
[46] Sun, Z., Bo, W., Jiang, P., et al. (2016) Different Types of Periampullary Duodenal Diverticula Are Associated with Occurrence and Recurrence of Bile Duct Stones: A Case-Control Study from a Chinese Center. Gastroenterology Research and Practice, 2016, Article ID: 9381759. [Google Scholar] [CrossRef] [PubMed]
[47] Kim, C.W., Chang, J.H., Kim, J.H., et al. (2013) Size and Type of Periampullary Duodenal Diverticula Are Associated with Bile Duct Diameter and Recurrence of Bile Duct Stones. Journal of Gastroenterology and Hepatology, 28, 893-898. [Google Scholar] [CrossRef] [PubMed]
[48] van Nieuwkoop, C., Boere, I., Rosekrans, P.A., et al. (2002) Recurrent Bacterial Cholangitis Due to a Juxtapapillary Diverticulum. European Journal of Gastroenterology & Hepatology, 14, 189-190. [Google Scholar] [CrossRef] [PubMed]
[49] Ozogul, B., Ozturk, G., Kisaoglu, A., et al. (2014) The Clinical Importance of Different Localizations of the Papilla Associated with Juxtapapillary Duodenal Diverticula. Canadian Journal of Surgery, 57, 337-341. [Google Scholar] [CrossRef] [PubMed]
[50] Kubota, Y., Yamaguchi, T., Tani, K., et al. (1993) Anatomical Variation of Pancreatobiliary Ducts in Biliary Stone Diseases. Abdominal Imaging, 18, 145-149. [Google Scholar] [CrossRef
[51] Sugiyama, M. and Atomi, Y. (2002) Risk Factors Predictive of Late Complications after Endoscopic Sphincterotomy for Bile Duct Stones: Long-Term (More than 10 Years) Follow-Up Study. American Journal of Gastroenterology, 97, 2763-2767. [Google Scholar] [CrossRef] [PubMed]
[52] Tsai, T.J., Lai, K.H., Lin, C.K., et al. (2015) Role of Endoscopic Papillary Balloon Dilation in Patients with Recurrent Bile Duct Stones after Endoscopic Sphincterotomy. Journal of the Chinese Medical Association, 78, 56-61. [Google Scholar] [CrossRef] [PubMed]
[53] Keizman, D., Ish, S.M. and Konikoff, F.M. (2006) Recurrent Symptomatic Common Bile Duct Stones after Endoscopic Stone Extraction in Elderly Patients. Gastrointestinal Endoscopy, 64, 60-65. [Google Scholar] [CrossRef] [PubMed]
[54] Tsai, T.J., Lai, K.H., Lin, C.K., et al. (2012) The Relationship between Gallbladder Status and Recurrent Biliary Complications in Patients with Choledocholithiasis Following Endoscopic Treatment. Journal of the Chinese Medical Association, 75, 560-566. [Google Scholar] [CrossRef] [PubMed]
[55] Yamamoto, R., Tazuma, S., Kanno, K., et al. (2016) Ursodeoxycholic Acid after Bile Duct Stone Removal and Risk Factors for Recurrence: A Randomized Trial. Journal of Hepato-Biliary-Pancreatic Sciences, 23, 132-136. [Google Scholar] [CrossRef] [PubMed]
[56] Chen, X., Yan, X.R. and Zhang, L.P. (2018) Ursodeoxycholic Acid after Common Bile Duct Stones Removal for Prevention of Recurrence: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore), 97, e13086. [Google Scholar] [CrossRef
[57] 陶鸣浩, 陆喜荣, 戴彦苗, 等. 柴芍四金汤预防ERCP术后胆总管结石复发的临床观察[J]. 南京中医药大学学报, 2019, 35(1): 36-38.
[58] 梁全. 阿拉坦五味丸在双镜联合保胆取石术后预防结石复发的临床研究[D]: [硕士学位论文]. 呼和浩特: 内蒙古医科大学, 2021.