KNDC1促细胞衰老作用的研究进展
Research Progress of KNDC1 Promoting Cell Senescence
DOI: 10.12677/ACM.2022.123219, PDF,    科研立项经费支持
作者: 方 敏*：延安大学，陕西 延安；周 静#：延安大学附属医院心内科，陕西 延安
关键词: 细胞衰老；激酶非催化C-叶结构域蛋白1；心血管疾病；Cell Senescence； Kinase Non-Catalytic C-Lobe Domain Containing 1； Cardiovascular Diseases
摘要: KNDC1被称为激酶非催化C-叶结构域蛋白1，是新发现的一种神经系统特异性鸟嘌呤核苷酸交换因子，在细胞的生长、增殖、分化、衰老过程中发挥着重要作用。KNDC1主要存在于小脑颗粒细胞中，其次在人脐静脉血管内皮细胞中也有相应表达，目前发现KNDC1与内皮细胞的衰老有关，过表达KNDC1会促进人脐静脉血管内皮细胞的衰老，而敲低则会延缓其衰老，并证明这一作用可能与细胞氧化应激有关。血管内皮细胞是血管的主要组成部分，血管内皮细胞衰老会导致血管的衰老，血管是多种心血管疾病的结构基础，因此研究血管内皮细胞的衰老具有重要意义。本文将就KNDC1参与细胞衰老过程的研究进展作一综述。
Abstract: KNDC1, called the kinase non-catalytic C-Leaf Domain Protein 1, is a newly discovered nervous system-specific guanine nucleotide exchange factor that plays an important role in the growth, proliferation, differentiation, and aging of cells. KNDC1 is mainly found in cerebellar granulosa cells, and followed in human umbilical vein vascular endothelial cells. At present, it is found that KNDC1 is related to endothelial cell aging. KNDC1 overexpression will promote the aging of vascular endothelial cells in human umbilical vein, while knocking down will slow its aging, which may be related to cell oxidative stress. Vascular endothelial cells are the main parts of blood vessels, the aging of vascular endothelial cells leads to the aging of blood vessels, blood vessels are the structural basis of various cardiovascular diseases, so it is of important significance to study the aging of vascular endothelial cells. This paper reviews the effects of KNDC1 and cell aging.
文章引用：方敏, 周静. KNDC1促细胞衰老作用的研究进展[J]. 临床医学进展, 2022, 12(3): 1515-1520. https://doi.org/10.12677/ACM.2022.123219

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